Subject(s)
Global Health , Health Knowledge, Attitudes, Practice , Smoking Cessation/legislation & jurisprudence , Smoking Prevention , Students, Medical , Adult , Croatia/epidemiology , Data Collection , Female , Health Policy , Health Promotion , Humans , Male , Pilot Projects , Public Health , Risk-Taking , Smoking/epidemiology , Smoking/legislation & jurisprudence , Smoking Cessation/methods , Social MarketingABSTRACT
Under the heading "How tobacco protects you against the flu", the German chemical industry portrays a tobacco grower in an idyllic tobacco plantation. Despite the recent ban of transnational tobacco advertising within the European Union, using tobacco to promote another industry and potential societal health benefits might indirectly promote the social acceptability of tobacco to social leaders. The tobacco control community should thus monitor the use of other industries as a new method to circumvent the tobacco advertising ban and to support the social acceptability of tobacco by associating it with potential health benefits.
Subject(s)
Advertising/standards , Chemical Industry , Humans , NicotianaABSTRACT
BACKGROUND: Aggregation and fibrillization of the alpha-synuclein protein (encoded by the SNCA gene) may represent key events in the pathogenesis of Parkinson disease (PD). Variability in the length of a dinucleotide repeat sequence (REP1) within the SNCA promoter confers susceptibility to sporadic PD. Pesticide exposures may also confer susceptibility to PD. Our objective was to test possible joint effects of SNCA REP1 genotypes and pesticide exposures on the risk of PD. METHODS: This was a case-control study. Cases were recruited prospectively from the Department of Neurology of the Mayo Clinic, Rochester, MN, after June 1, 1996. The control subjects included unaffected siblings of cases and unrelated population control subjects. We assessed pesticide exposures by telephone interview and genotyped SNCA REP1. Odds ratios (ORs) and 95% CIs were determined using conditional logistic regression models. RESULTS: There were 833 case-control pairs. We observed an increased risk of PD with increasing SNCA REP1 bp length (OR, 1.18 for each score unit; 95% CI, 1.02-1.37; p = 0.03). Pesticide exposures were associated with PD in younger subjects only (lowest quartile of age at study, Subject(s)
Parkinson Disease, Secondary/chemically induced
, Parkinson Disease, Secondary/genetics
, Pesticides/adverse effects
, alpha-Synuclein/genetics
, Adult
, Age Factors
, Aged
, Aged, 80 and over
, Case-Control Studies
, Dinucleotide Repeats/genetics
, Female
, Genetic Variation
, Genotype
, Humans
, Male
, Middle Aged
, Prospective Studies
, Risk Factors
ABSTRACT
The malarial parasite Plasmodium vivax causes disease in humans, including chronic infections and recurrent relapses, but the course of infection is rarely fatal, unlike that caused by Plasmodium falciparum. To investigate differences in pathogenicity between P. vivax and P. falciparum, we have compared the subtelomeric domains in the DNA of these parasites. In P. falciparum, subtelomeric domains are conserved and contain ordered arrays of members of multigene families, such as var, rif and stevor, encoding virulence determinants of cytoadhesion and antigenic variation. Here we identify, through the analysis of a continuous 155,711-base-pair sequence of a P. vivax chromosome end, a multigene family called vir, which is specific to P. vivax. The vir genes are present at about 600-1,000 copies per haploid genome and encode proteins that are immunovariant in natural infections, indicating that they may have a functional role in establishing chronic infection through antigenic variation.
