Ricin and Ricinus communis in pharmacology and toxicology-from ancient use and "Papyrus Ebers" to modern perspectives and "poisonous plant of the year 2018".

While probably originating from Africa, the plant Ricinus communis is found nowadays around the world, grown for industrial use as a source of castor oil production, wildly sprouting in many regions, or used as ornamental plant. As regards its pharmacological utility, a variety of medical purposes of selected parts of the plant, e.g., as a laxative, an anti-infective, or an anti-inflammatory drug, have been described already in the sixteenth century BC in the famous Papyrus Ebers (treasured in the Library of the University of Leipzig). Quite in contrast, on the toxicological side, the native plant has become the "poisonous plant 2018" in Germany. As of today, a number of isolated components of the plant/seeds have been characterized, including, e.g., castor oil, ricin, Ricinus communis agglutinin, ricinin, nudiflorin, and several allergenic compounds. This review mainly focuses on the most toxic protein, ricin D, classified as a type 2 ribosome-inactivating protein (RIP2). Ricin is one of the most potent and lethal substances known. It has been considered as an important bioweapon (categorized as a Category B agent (second-highest priority)) and an attractive agent for bioterroristic activities. On the other hand, ricin presents great potential, e.g., as an anti-cancer agent or in cell-based research, and is even explored in the context of nanoparticle formulations in tumor therapy. This review provides a comprehensive overview of the pharmacology and toxicology-related body of knowledge on ricin. Toxicokinetic/toxicodynamic aspects of ricin poisoning and possibilities for analytical detection and therapeutic use are summarized as well.

[The Hippocratic Oath: how many covenants, how many oaths?]. / Der Hippokratische Eid: Wie viele Verträge und wie viele Eide?

This study focuses on the ancient text of the Hippocratic Oath. Ancient authors refer to various oaths in the context of medical practice, but none of these closely resemble the Hippocratic Oath. The text of the Hippocratic Oath contains several contractual clauses, which clearly reflect a strictly structured community within an institutionalized professional framework. Comparison with the epigraphic and papyrological tradition suggests placing the text in the Hellenistic-Roman period. In particular, investigation of the oldest remaining ancient textual witness, the POxy XXXI 2547 of the third century A.D., reveals Christian influences in the use of language. This indicates a stage of development of the Hippocratic Oath in which the latter existed within a Christian context. The article concludes that, as early as the third century A.D., Christian influences played an equally significant role in the transmission of the Oath as pagan influences.