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1.
Braz J Med Biol Res ; 56: e12850, 2023.
Article in English | MEDLINE | ID: mdl-38126536

ABSTRACT

Depression is a common disorder in patients with chronic kidney disease (CKD), and some data support its relationship with functional capacity and quality of life. However, to date, this has not been evaluated systematically or through meta-analysis. We sought to investigate the relationship of quality of life and functional capacity with depressive disorder in patients with CKD on hemodialysis. This systematic review considered studies published up to 2021 and included cross-sectional and cohort studies. PubMed, Embase, SPORTDiscus, Web of Science, and Cochrane (CENTRAL) databases were used to search for studies. The New Castle-Ottawa Quality Assessment scale was used to measure the quality of the studies. A total of 4,626 studies were found and, after applying the selection criteria, 16 studies (2,175 patients) remained for qualitative analysis and 10 for meta-analysis (1,484 patients). The physical component summary (MD=-6.563; 95%CI: -9.702 to -3.424) and mental component summary (MD=-18.760; 95%CI: -28.641 to -8.879) were lower in depressive patients, as in all Short Form Health Survey 36 (SF-36) domains. Only one study provided data regarding functional capacity, but it was not evaluated by the defined outcome measure. Twelve studies were classified as "moderate quality" (5 to 6 stars) and four were classified as "low-quality" (0 to 4 stars). This meta-analysis with CKD patients on hemodialysis showed a negative relationship between depression and quality of life, with worsening in all physical and mental domains of the SF-36 in depressed patients.


Subject(s)
Quality of Life , Renal Insufficiency, Chronic , Humans , Cross-Sectional Studies , Renal Dialysis , Renal Insufficiency, Chronic/complications , Renal Insufficiency, Chronic/therapy
2.
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;56: e12850, 2023. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1528092

ABSTRACT

Depression is a common disorder in patients with chronic kidney disease (CKD), and some data support its relationship with functional capacity and quality of life. However, to date, this has not been evaluated systematically or through meta-analysis. We sought to investigate the relationship of quality of life and functional capacity with depressive disorder in patients with CKD on hemodialysis. This systematic review considered studies published up to 2021 and included cross-sectional and cohort studies. PubMed, Embase, SPORTDiscus, Web of Science, and Cochrane (CENTRAL) databases were used to search for studies. The New Castle-Ottawa Quality Assessment scale was used to measure the quality of the studies. A total of 4,626 studies were found and, after applying the selection criteria, 16 studies (2,175 patients) remained for qualitative analysis and 10 for meta-analysis (1,484 patients). The physical component summary (MD=-6.563; 95%CI: −9.702 to −3.424) and mental component summary (MD=-18.760; 95%CI: −28.641 to −8.879) were lower in depressive patients, as in all Short Form Health Survey 36 (SF-36) domains. Only one study provided data regarding functional capacity, but it was not evaluated by the defined outcome measure. Twelve studies were classified as "moderate quality" (5 to 6 stars) and four were classified as "low-quality" (0 to 4 stars). This meta-analysis with CKD patients on hemodialysis showed a negative relationship between depression and quality of life, with worsening in all physical and mental domains of the SF-36 in depressed patients.

3.
Scand J Med Sci Sports ; 27(3): 351-358, 2017 Mar.
Article in English | MEDLINE | ID: mdl-26833853

ABSTRACT

We compare the effects of Nordic walking training (NW) and Free walk (FW) on functional parameters (motor symptoms, balance) and functional mobility (Timed Up and Go at Self-selected Speed - TUGSS, and at forced speed, TUGFS; Self-selected Walking Speed, SSW; locomotor rehabilitation index, LRI) of Parkinson's disease (PD) patients. The study included 33 patients with clinical diagnosis of idiopathic PD, and staging between 1 and 4 in the Hoehn and Yahr scale (H&Y) randomized into two groups: NW (N = 16) and FW (N = 17) for 6 weeks. Baseline characteristics were compared trough a one-way ANOVA. Outcomes were analyzed using the Generalized Estimation Equations (GEE) with a Bonferroni post-hoc. Data were analyzed using SPSS v.20.0. Improvements in UPDRS III (P < 0.001), balance scores (P < 0.035), TUGSS distance (P < 0.001), TUGFS distance (P < 0.001), SSW (P < 0.001), and LRI (P < 0.001) were found for both groups. However, the NW group showed significant differences (P < 0.001) when compared to the FW group for the functional mobility. We conclude the NW improves functional parameters and walking mobility demonstrating that NW is as effective as the FW, including benefits for FW on the functional mobility of people with PD.


Subject(s)
Exercise Therapy/methods , Parkinson Disease/rehabilitation , Walking , Aged , Female , Humans , Male , Middle Aged , Parkinson Disease/physiopathology , Severity of Illness Index
4.
J Affect Disord ; 133(3): 615-8, 2011 Oct.
Article in English | MEDLINE | ID: mdl-21616540

ABSTRACT

BACKGROUND: Physical exercise has been extensively researched as a therapeutic option for treatment of major depression. METHODS: In a randomized controlled trial, we analyze the effects of aerobic physical exercise as an add-on strategy for treatment of severe depressed inpatients. The exercise has a "Dose" of 16.5 kcal/kg/week, three times a week during all the hospitalization. RESULTS: Our preliminary results show that there is no significant difference in scores of Hamilton in the second week between groups (Mean[SD]=8.2[5.96] × 11.18[5.03], p=0.192). However, there is a significant reduction in Hamilton scores of patients in exercise group at discharge (Mean[SD]=5.93[4.46] × 9.45[3.56], p=0.041). Regarding Quality of Life (QoL), no significant difference were found between groups in the second week in physical domain (Mean[SD]=56.98[8.96] × 54.54[9.18], p=0.511) and psychological domain (Mean[SD]=50.88[13.88] × 42.04[12.42], p=0.106). However, there is a significant difference in psychological domain (Mean[SD]=55.88[9.92] v 41.66[13.04], p=0.004) and a trend but no statistical significance in the physical (Mean[SD]=58.80[9.14] × 52.12[8.70], p=0.07) at discharge. LIMITATIONS: Many patients receive different treatment strategies, like ECT (1 patient at exercise group × 3 at control group). Other limitation is the small number of participants included until this moment. CONCLUSION: Our preliminary results suggest that physical exercise could be a feasible and effective add-on strategy for treatment of severe depressed inpatients, improving their depressive symptoms and QoL.


Subject(s)
Depressive Disorder/therapy , Exercise Therapy , Quality of Life , Adult , Depression/therapy , Depressive Disorder/psychology , Depressive Disorder, Major/diagnosis , Depressive Disorder, Major/therapy , Energy Intake , Exercise/psychology , Female , Humans , Male , Middle Aged , Treatment Outcome
5.
Rev. cir. infant ; 9(2): 102-7, jun. 1999. ilus, tab
Article in Spanish | LILACS | ID: lil-247633

ABSTRACT

La fijación testicular se realiza para prevenir la torsión del órgano y en la corrección de la criptorquidia.Se han utilizado para ello diversas técnicas,persistiendo discordancia respecto a cúal es la mejor,con menor daño testicular.Este estudio se realizó para comparar la fijación y el grado de lesión testicular con distintas técnicas quirúrgicas,utilizando dos tipos de sutura.Cuarenta ratas adultas de la raza Wistar,anestesiadas con eter etílico se sometieron a la incisión del escroto y exposición de ambos testículos.Se definieron en forma aleatoria cuatro grupos:grupo 1(n=10)fijación con un punto único,grupo 2(n=10)al que se fijó el testículo con dos puntos,grupo 3(n=10)en el que el testículo se fijó con tres puntos.En la mitad de los animales fue utilizado Vicryl 5-0,y en le resto se utilizó Mersilene 5-0,en el grupo 4 (n=10)el testículo se colocó en la bolsa sabdártica sin puntos de sutura.El testículo contralateral no tratado fue utilizado como control.Todos los animales se sacrificaron a los 30 días,evaluándose el grado de fijación macroscópica,eltamaño del testículo,y las alteraciones microscópicas del mismo.Todos los animales completaron el período previsto de observación.Se observó una diferencia significativa de la fijación entre los grupos(p<0,0038):los animales del grupo 1 presentaron una fijación menor respecto a los otrso grupos.Entre los grupos 2,3 y 4 no se observó una diferencia significativa en la fijación,tampoco hubo diferencia entre los animales del mismo grupo suturados con vicryl o mersilene.No se observaron alteraciones inflamatorias testiculares estadísticamente significativas entre los grupos ni entre los animales del mismo grupo fijados con las dos suturas.La fijación testicular con 2 o 3 puntos en la bolsa subdártica es superios a la realizada con un punto único.Esta última provoca alteraciones semejantes a las encontradas con las otras técnicas,que produce significativamente menor fijación


Subject(s)
Animals , Rats , Testis/surgery
6.
Rev. cir. infant ; 9(2): 102-7, jun. 1999. ilus, tab
Article in Spanish | BINACIS | ID: bin-14414

ABSTRACT

La fijación testicular se realiza para prevenir la torsión del órgano y en la corrección de la criptorquidia.Se han utilizado para ello diversas técnicas,persistiendo discordancia respecto a cúal es la mejor,con menor daño testicular.Este estudio se realizó para comparar la fijación y el grado de lesión testicular con distintas técnicas quirúrgicas,utilizando dos tipos de sutura.Cuarenta ratas adultas de la raza Wistar,anestesiadas con eter etílico se sometieron a la incisión del escroto y exposición de ambos testículos.Se definieron en forma aleatoria cuatro grupos:grupo 1(n=10)fijación con un punto único,grupo 2(n=10)al que se fijó el testículo con dos puntos,grupo 3(n=10)en el que el testículo se fijó con tres puntos.En la mitad de los animales fue utilizado Vicryl 5-0,y en le resto se utilizó Mersilene 5-0,en el grupo 4 (n=10)el testículo se colocó en la bolsa sabdártica sin puntos de sutura.El testículo contralateral no tratado fue utilizado como control.Todos los animales se sacrificaron a los 30 días,evaluándose el grado de fijación macroscópica,eltamaño del testículo,y las alteraciones microscópicas del mismo.Todos los animales completaron el período previsto de observación.Se observó una diferencia significativa de la fijación entre los grupos(p<0,0038):los animales del grupo 1 presentaron una fijación menor respecto a los otrso grupos.Entre los grupos 2,3 y 4 no se observó una diferencia significativa en la fijación,tampoco hubo diferencia entre los animales del mismo grupo suturados con vicryl o mersilene.No se observaron alteraciones inflamatorias testiculares estadísticamente significativas entre los grupos ni entre los animales del mismo grupo fijados con las dos suturas.La fijación testicular con 2 o 3 puntos en la bolsa subdártica es superios a la realizada con un punto único.Esta última provoca alteraciones semejantes a las encontradas con las otras técnicas,que produce significativamente menor fijación


Subject(s)
Animals , Rats , Testis/surgery
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