1.
J Pediatr
; 145(5): 698-700, 2004 Nov.
Article
in English
| MEDLINE
| ID: mdl-15520784
ABSTRACT
We describe two siblings with one confirmed and one inferred homozygous base pair deletion in the gene for interleukin-1-related kinase 4 (IRAK-4) who died of pneumococcal meningitis at 2 and 14 months, respectively. Interleukin-1-related kinase 4 deficiency is a potentially lethal immunodeficiency characterized by a poor inflammatory response to pyogenic infections.