ABSTRACT
New hippocampal neurons are continuously generated in the adult human brain. Several studies have demonstrated that the proliferation of hippocampal cells is strongly influenced by a variety of stimuli, including pesticides exposure. These effects are particularly important because neurogenesis dysregulation could be associated with the decline of neuronal and cognitive functions and the possible development of neuropsychiatric disorders.
Novos neurônios hipocampais são gerados continuamente no cérebro humano adulto. Vários estudos têm demonstrado que a proliferação de células do hipocampo é influenciada por uma variedade de estímulos, incluindo a exposição a pesticidas. Estes efeitos são particularmente importantes porque a desregulação da neurogênese pode estar associada ao declínio das funções neuronais e cognitivas e ao possível desenvolvimento de doenças neuropsiquiátricas.
Subject(s)
Hippocampus , Neurogenesis , Neurons , Pesticides , Pesticides/toxicity , Humans , Hippocampus/drug effects , Hippocampus/physiology , Neurogenesis/drug effects , Neurogenesis/physiology , Neurons/drug effects , Neurons/physiology , AnimalsSubject(s)
Diaphragm , Intensive Care Units , Quadriceps Muscle , Tracheostomy , Ventilator Weaning , Humans , Male , Female , Middle Aged , AgedSubject(s)
Cerebral Palsy , Humans , Cerebral Palsy/physiopathology , Sleep Quality , Digestion/physiologySubject(s)
Fibrinolytic Agents , Thrombolytic Therapy , Tissue Plasminogen Activator , Humans , Tissue Plasminogen Activator/therapeutic use , Tissue Plasminogen Activator/administration & dosage , Fibrinolytic Agents/therapeutic use , Thrombolytic Therapy/methods , Reperfusion/methods , Recombinant Proteins/therapeutic useSubject(s)
Death, Sudden , Parkinson Disease , Humans , Parkinson Disease/mortality , Death, Sudden/etiology , Male , Female , Aged , Hospital Mortality , Middle Aged , Risk Factors , Brazil/epidemiology , Aged, 80 and overSubject(s)
COVID-19 , Peripheral Nervous System Diseases , Humans , COVID-19/complications , SARS-CoV-2ABSTRACT
Aging populations worldwide are placing age-related diseases at the forefront of the research agenda. The therapeutic potential of natural substances, especially propolis and its components, has led to these products being promising agents for alleviating several cellular and molecular-level changes associated with age-related diseases. With this in mind, scientists have introduced a contextual framework to guide future aging research, called the hallmarks of aging. This framework encompasses various mechanisms including genomic instability, epigenetic changes, mitochondrial dysfunction, inflammation, impaired nutrient sensing, and altered intercellular communication. Propolis, with its rich array of bioactive compounds, functions as a potent functional food, modulating metabolism, gut microbiota, inflammation, and immune response, offering significant health benefits. Studies emphasize propolis' properties, such as antitumor, cardioprotective, and neuroprotective effects, as well as its ability to mitigate inflammation, oxidative stress, DNA damage, and pathogenic gut bacteria growth. This article underscores current scientific evidence supporting propolis' role in controlling molecular and cellular characteristics linked to aging and its hallmarks, hypothesizing its potential in geroscience research. The aim is to discover novel therapeutic strategies to improve health and quality of life in older individuals, addressing existing deficits and perspectives in this research area.
Subject(s)
Propolis , Humans , Aged , Propolis/metabolism , Propolis/therapeutic use , Quality of Life , Aging/metabolism , Oxidative Stress , Inflammation/drug therapyABSTRACT
This letter is a comment on the 2023 article entitled "Effect of xanthophyll-rich food and supplement intake on visual outcomes in healthy adults and those with eye disease: a systematic review, meta-analysis, and meta-regression of randomized controlled trials," recently published in Nutrition Reviews, by Hu et al.
