1.
Chem Pharm Bull (Tokyo)
; 60(8): 1063-6, 2012.
Article
in English
| MEDLINE
| ID: mdl-22863711
ABSTRACT
The preparation of novel tetrahydro-1H-pyrazolo[4,3-c]pyridines is reported. Pivotal to the synthesis of these compounds was the development of mild reaction conditions to generate a highly functionalized nitrilimine capable of undergoing an intramolecular cycloaddition with a tethered alkyne. The desired cycloadduct was formed as an equal mixture of diastereomers.