ABSTRACT
Ethmoid adenocarcinoma is a rare tumour of the ethmoidal sinuses. The authors report on the clinical features, treatment and follow-up results in 19 cases. Risk factors were those regularly encountered. Delay to diagnosis was long due to the nonspecific clinical features and course. Nasal endoscopy was essential for follow-up. Computed tomography and magnetic resonance imaging were also required to assess tumour spread. Our results suggest that radiotherapy following surgery should be preferred. Survival rate is generally low for this type of tumor. We had 77% survival at 5 years.
Subject(s)
Adenocarcinoma/diagnosis , Adenocarcinoma/mortality , Ethmoid Sinus/diagnostic imaging , Ethmoid Sinus/pathology , Paranasal Sinus Neoplasms/diagnosis , Paranasal Sinus Neoplasms/mortality , Adenocarcinoma/therapy , Aged , Catchment Area, Health , Combined Modality Therapy , Ethmoid Sinus/surgery , Female , Follow-Up Studies , France/epidemiology , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Neoplasm Invasiveness , Neoplasm Staging , Paranasal Sinus Neoplasms/therapy , Postoperative Care , Prognosis , Retrospective Studies , Survival Rate , Tomography, X-Ray ComputedABSTRACT
Radiation-induced bile duct strictures are rare since bile ducts are considered to be resistant in radiation injury. We report a case of bile duct stenosis where evidence is presented that bile duct stricture was the result of radiation injury and which illustrates the major contribution of magnetic res-onance cholangiography in biliary tract disease evaluation.
Subject(s)
Bile Duct Diseases/diagnosis , Bile Duct Diseases/etiology , Bile Ducts/radiation effects , Hodgkin Disease/radiotherapy , Radiation Injuries/complications , Cholangiography , Constriction, Pathologic/diagnosis , Constriction, Pathologic/etiology , Humans , Magnetic Resonance Imaging/methods , Male , Middle AgedABSTRACT
PURPOSE: To evaluate the best strategy for treatment of sarcoma that occurs after radiation therapy. MATERIALS AND METHODS: Records were retrospectively reviewed for 80 patients with a confirmed histologic diagnosis of sarcoma that occurred after radiation therapy performed during 1975-1995. The patients were treated for breast cancer (n = 33, 42%), non-Hodgkin lymphoma (n = 9, 11%), cervical cancer (n = 9, 11%), benign lesions (n = 4, 5%), or other tumors (n = 25, 31%). Sarcoma occurred after a mean latency of 12 years (range, 3-64 years), with most (70%) developing in the soft tissue. Treatment included surgery (28 patients), surgery and chemotherapy (18 patients), chemotherapy only (15 patients), and radiation therapy (14 patients). RESULTS: By the end of the study, 51 patients were dead, including 46 due to sarcoma. Median survival was 23 months. Overall survival rates at 2 and 5 years, respectively, were 69% and 39% for patients treated with surgery, 10% and 0% for those treated with chemotherapy, and 52% and 35% for those treated with surgery and chemotherapy (P =.001). The 2- and 5-year rates for survival without recurrence were 54% and 32%, respectively. CONCLUSION: The results confirm the beneficial effect of surgery. Further study is needed to explore the roles of combined treatments.
