[Plasma management in complex treatment of late inflammatory complications after injection contour plasty with polyacrylamide gel]. / Plazmennaia obrabotka pri lechenii pozdnikh vospalitel'no-gnoinykh oslozhnenii in''ektsionnoi konturnoi plastiki poliakrilamidnym gelem.

AIM: To improve the results of treatment of late inflammatory complications after injection contour plasty with polyacrylamide gel. MATERIAL AND METHODS: The authors analyze treatment of 21 patients with late septic complications of body contour plasty with polyacrylamide gel (PAGE) for the period 2010-2015. Mean age of women was 47.4 years. Time after primary intervention was 10-22 years. The depth of soft tissue lesion corresponded to II-III grade by D. Ahrenholz classification (1991), length - from 67 to 180 cm2. Mammary glands were the most common area of augmentation (18 cases). Besides antibiotic therapy and surgery complex treatment included exposure with plasma flows in various modes. RESULTS: Plasma technology significantly accelerated regenerative processes and provided stable microbial decontamination in 100% patients. High-energy vaporization was associated with maximum possible removal of PAGE from the tissues that was confirmed by histological examination.

[Prognostic value of the expression of thyreoglobulin and oncomarkers (p53, EGFR, ret-oncogene) in different types of papillary carcinoma of the thyroid: clinicomorphological and immunohistochemical studies].

The surgical material obtained from 57 patients was immunohistochemically studied. Immunohistochemistry with quantitative and semiquantitative analyses of the results of test was used to define the expression of oncomarkers p53, EGRF, ret-oncogene, and thyreoglobulin. The expression of thyreoglobulin, EGRF, and ret-oncogene reflects the malignant potential of papillary carcinoma of the thyroid and and may be recommended as a predictive marker. The low expression of thyreoglobulin and the high expression of p53 and ret-oncogene are markers of a poor prognosis and tumor recurrence. EGFR expression is not of predictive value. MB3 proposed by the authors may be recommended for the determination of the malignant potential of papillary carcinoma of the thyroid.

[Diagnostics of microcirculatory disorders in patients with diabetes mellitus type 2 and ischemic heart disease]. / Diagnostika mikrotsirkuliatornykh narushenii y bol'hykh sakharnym diabetom tipa 2 i ishemicheskoi bolezn'iu serdtsa.

Skin biopsy is the most significant method for diagnosis of microcirculatory disorders in diabetes mellitus of type 2 (DM2) and ischemic heart disease (IHD). This method provides earlier detection of microcirculatory changes which is essential for prophylaxis of life-threatening vascular complications and early treatment. 29 IHD and DM2 patients were examined. In the period of DM compensation and stable angina these patients underwent incision biopsy. Morphological preparations were studied histologically and immunohistochemically. The data obtained allowed estimation of the mean time of development of diabetic microangiopathy (MAP) in these patients. The results show that in combination of DM2 and IHD microcirculatory disorders in skin biopsies develop later than in DM2 without IHD; MAP progression correlates with DM duration; clinical compensation of patients with IHD and DM2 depresses progression of DMA. A method of choice in diagnosis of microcirculatory disorders in DM patients is skin biopsy.

[Ultrasonic method of study and puncture biopsy in diagnosing thyroid nodules]. / Ul'trazvukovye metody issledovaniia i punktsionnaia biopsiia v diagnostike uzlovykh obrazovanii shchitovidnoi zhelezy.

Results of diagnosis of thyroid nodes in 404 patients are analyzed. Ultrasonic examination and US-assisted puncture biopsy were carried out before operations. Their results were compared with ones of morphologic study performed after surgery. Solitary nodes were diagnosed in 171 (42.3%) patients, multiple--in 233 (57.7%). The most specific ultrasonic symptoms of different forms of thyroid nodes were revealed. Thyroid cancer is imaged as hypoechogenic node with clear and unclear contour, heterogeneous structure, multiple zones of hyperechogenicity and calcification. Adenomas are presented as isoechogenic homogenic nodes with clear border and cystic cavities. Colloid nodes picture is the same. Rathen often different morphologic forms of nodes are similar, thus ultrasonic examination permits to detect morphologic structure of nodes hypothetically only. Sensitivity of puncture biopsy for goiter, adenomas and cancer was 87.1, 92.9 and 69.7% respectively. Cancer was not diagnosed before surgery in 30.3% cases when colloid goiter or adenomas were suspected. In these cases small cancer was located amidst colloid nodes and didn't differ by ultrasonic symptoms. Diagnosis of malignant tumor in nodular goiter was highly precise. Morphologic form of cancer was verified cytologically in majority of cases.

[Histological and molecular-biological markers of malignancy in different variants of thyroid papillary carcinoma]. / Gistologicheskie i molekuliarno-biologicheskie markery zlokachestvennosti v razlichnykh variantakh papilliarnogo raka shchitovidnoi zhelezy.

Material for this study from 61 patients (thyroid papillary carcinoma) is shown to represent a heterogenic group of tumors differing from each other morphologically, molecular-biologically and histogenetically. The most malignant were long-cell and B-cell variants and the least malignant--a follicular variant. 81% of the tumors had neuro-endocrine differentiation and their malignant potential was higher compared to tumors without this differentiation.

[Prognostic index in cancer of the thyroid gland]. / Prognosticheskii indeks pri rake shchitovidnoi zhelezy.

A retrospective investigation of 92 patients operated upon for thyroid carcinoma was performed with the help of a prognostic index. The prognostic index built on the basis of multifactorial analysis allows to form risk groups and to detect five-year survival.

[Adenoma of the nipple with malignant degeneration]. / Adenoma soska s malignizatsiei.

A rare nipple tumor observed in a 75-year-old woman is reported. The tumor was initially diagnosed on morphologic criteria as a nipple adenoma, but detailed examination of a segmental resection specimen revealed areas of malignant change resembling intraduct cancer. The patient underwent amputation of the mammary gland, and examination of the operative specimen demonstrated microfoci of invasive growth into lymphatic clefts.