1.
ACS Med Chem Lett
; 10(1): 137-141, 2019 Jan 10.
Article
in English
| MEDLINE
| ID: mdl-30655961
ABSTRACT
Malaria is a major tropical disease where important needs are to mitigate symptoms and to prevent the establishment of infection. Cyclopeptides containing N-methyl amino acids with in vitro activity against erythrocytic forms as well as liver stage are presented. The synthesis, parasitological characterization, physicochemical properties, in vivo evaluation, and mice pharmacokinetics are described.
2.
ACS Comb Sci
; 18(5): 225-9, 2016 05 09.
Article
in English
| MEDLINE
| ID: mdl-27073985
ABSTRACT
A versatile palladium-catalyzed tandem synthetic sequence to afford E-stilbenes libraries has been developed. Excellent regio- and stereocontrol have been achieved by means of the sequence of Hiyama and Heck cross-couplings. Undesirable homocoupling byproducts were avoided employing immobilized substrates.