ABSTRACT
OBJETIVO: El objetivo es evaluar las nuevas infecciones por el virus de la hepatitis C (VHC) en función de su orientación sexual, situación serológica respecto al virus de la inmunodeficiencia humana (VIH), región geográfica de origen y la coinfección con otras infecciones de transmisión sexual (ITS). MATERIAL Y MÉTODOS: Estudio realizado en el Centro Sanitario Sandoval clínica de referencia de ITS en Madrid. Se incluyeron todas las personas seronegativas al VHC que fueron reanalizadas para este virus, entre enero de 2010 y diciembre de 2016. RESULTADOS: Se diagnosticaron 59 nuevos diagnósticos de infección por el VHC. La proporción de hombres que tienen sexo con hombres (HSH) dentro de los nuevos diagnósticos fue del 37% en 2010 y del 75% en 2016 y, fue aún mayor, en el grupo de coinfectados por el VIH/VHC (94%). Se detectaron 67 seroconvertores al VHC (1,2%). El 100% eran HSH. El 89% de los seroconvertores al VHC eran seropositivos para el VIH. CONCLUSIONES: La infección por el VHC sigue siendo un problema de salud vigente, especialmente en colectivos de riesgo, como los HSH seropositivos para el VIH
INTRODUCTION: The aim of this study was to evaluate the incidence of new hepatitis C virus (HCV) infections, based on their sexual orientation, human immunodeficiency virus (HIV) status, geographical regions and coinfection with other sexually transmitted diseases (STDs). MATERIAL AND METHODS: This study was carried out at the Sandoval Health Center, reference clinic of Sexually Transmitted Diseases (STDs) in Madrid. All HCV seronegative individuals who were reanalyzed for this virus were included, between January 2010 and December 2016. RESULTS: A total of 59 new diagnoses of HCV were diagnosed. The proportion of men who have sex with men (MSM) diagnosed with HCV was 37% in 2010 and 75% in 2016 and was even higher in the group of coinfected with HIV/HCV (94%). A total of 67 seroconverters for HCV were detected (1.2%) of which 100% were MSM. The proportion of HCV seroconverters with HIV was 89%. CONCLUSIONS: HCV infection continues to be a current health problem, especially in HIV-positive MSM
Subject(s)
Humans , Male , Female , Adult , HIV Infections/epidemiology , Hepatitis C/epidemiology , Sexual Behavior/statistics & numerical data , Coinfection/epidemiology , HIV Infections/immunology , Hepatitis C/diagnosis , Homosexuality, Male/statistics & numerical data , Incidence , Retrospective Studies , Sexually Transmitted Diseases/epidemiology , Spain/epidemiology , Transgender Persons/statistics & numerical dataABSTRACT
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare inherited cerebrovascular disease associated with mutations in the NOTCH3 gene on chromosome 19, and represents the most common hereditary stroke disorder. We describe a pedigree, which suffered the classical clinical CADASIL pattern of migraine headaches, recurrent subcortical infarcts, and subcortical dementia, associated with a previously undescribed missense mutation (c.[244T>C], p.[C82R]) in NOTCH3. This new mutation extends the list of known pathogenic mutations responsible for CADASIL, which are associated with an odd number of cysteine residues within any of the epidermal growth factor-like repeats of Notch3 receptor protein.
Subject(s)
Arginine/genetics , CADASIL/genetics , Cysteine/genetics , Mutation/genetics , Receptors, Notch/genetics , Aged , Brain/pathology , CADASIL/pathology , Family Health , Female , Genetic Association Studies , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Receptor, Notch3Subject(s)
Immunocompetence , Meningitis, Bacterial/microbiology , Streptococcal Infections/microbiology , Streptococcus agalactiae/isolation & purification , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/therapeutic use , Cardiotonic Agents/therapeutic use , Ceftriaxone/administration & dosage , Ceftriaxone/therapeutic use , Combined Modality Therapy , Communicable Diseases, Emerging , Drug Therapy, Combination , Humans , Male , Meningitis, Bacterial/cerebrospinal fluid , Meningitis, Bacterial/drug therapy , Meningitis, Bacterial/etiology , Middle Aged , Pharyngitis/complications , Pharyngitis/drug therapy , Pharyngitis/microbiology , Respiration, Artificial , Sepsis/drug therapy , Sepsis/etiology , Sepsis/microbiology , Sepsis/therapy , Streptococcal Infections/cerebrospinal fluid , Streptococcal Infections/drug therapy , Vancomycin/administration & dosage , Vancomycin/therapeutic useSubject(s)
Humans , Male , Middle Aged , Meningitis/diagnosis , Meningitis/drug therapy , Meningitis/microbiology , Streptococcus agalactiae , Streptococcus agalactiae/isolation & purification , Diagnosis, Differential , Comorbidity , Radiography, Thoracic/methods , Radiography, Thoracic/trends , Ceftriaxone/therapeutic use , Vancomycin/therapeutic useABSTRACT
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Subject(s)
Middle Aged , Female , Humans , Bacteremia , Streptococcus bovis , Meningitis, Bacterial , Central Nervous System Bacterial Infections , Anti-Bacterial Agents , Cefotaxime , AmpicillinSubject(s)
Meningitis, Bacterial/microbiology , Streptococcus bovis/drug effects , Ampicillin/therapeutic use , Anti-Bacterial Agents/therapeutic use , Bacteremia/diagnosis , Bacteremia/drug therapy , Bacteremia/microbiology , Cefotaxime/therapeutic use , Central Nervous System Bacterial Infections/diagnosis , Central Nervous System Bacterial Infections/drug therapy , Female , Humans , MEDLINE , Meningitis, Bacterial/diagnosis , Meningitis, Bacterial/drug therapy , Middle AgedABSTRACT
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