ABSTRACT
Myiasis is a rare parasitic condition, caused by fly larvae infesting human tissues. Its consequences can be severe, as deafness, blindness, extensive tissue loss, and even death can occur due to the infestation. We present a case of myiasis in a 62-year-old Pakistani woman with advanced well-differentiated oral squamous cell carcinoma (OSCC) undergoing palliative chemotherapy. The patient presented with an extensive, necrotic lesion in the submental and submandibular region infested with live larvae. Management included mechanical removal over three sessions and ivermectin. Once all the larvae were eradicated, the patient was referred to the plastic surgery department for reconstruction. This case report highlights the importance of maintaining a high index of suspicion for myiasis in patients with OSCC, particularly those with extensive ulcerated lesions. Educating at-risk individuals and healthcare providers on myiasis and the importance of wound hygiene is crucial for reducing the burden of this preventable complication.