ABSTRACT
In this study, a novel Schiff base was synthesized which comprises a core moiety of 2-butyl-4-chloro imidazole. The ligand was synthesized by the reaction between the carbonyl compound 4-[(2-butyl-4-chloro-5-formyl-1H-imidazol-1-yl) methyl] benzoate and primary hydrazine compounds such as 2,4-dinitrophenylhydrazine in the presence of an alcoholic solvent and an acid catalyst. The synthesized Schiff base ligand is characterized by mass and spectral analysis including NMR. The appearance of extended conjugation of the π-electrons system between active 2-butyl-4-chloro imidazole moieties with nitro substituted phenyl ring. The ligands are assessed for an antibacterial activity for Escherichia coli and Staphylococcus aureus to evaluate the inhibition potential by MIC and well diffusion method. The biological activity of the ligand has shown a significant property against the Gram-negative bacterium, E. coli, and Gram-positive bacterium, S. aureus of about 27 mm and 28 mm of inhibitory action, respectively. This study paves the way for the development of novel antimicrobial agents for emerging clinical pathogens.
Subject(s)
Anti-Infective Agents , Schiff Bases , Schiff Bases/pharmacology , Schiff Bases/chemistry , Escherichia coli , Staphylococcus aureus , Ligands , Anti-Infective Agents/pharmacology , Anti-Infective Agents/chemistry , Anti-Bacterial Agents/chemistry , Imidazoles/pharmacology , Imidazoles/chemistry , Microbial Sensitivity TestsABSTRACT
Pillar[n]arenes are a new class of synthetic supramolecular macrocycles streamlined by their particular pillar-shaped architecture which consists of an electron-rich cavity and two fine-tuneable rims. The ease and diversity of the functionalization of the two rims open possibilities for the design of new architectures, topological isomers, and scaffolds. Significantly, this emerging class of macrocyclic receptors offers a unique platform for biological purposes. This review article covers the most recent contributions from the pillar[n]arene field in terms of artificial membrane transport systems, controlled drug delivery systems, biomedical imaging, biosensors, cell adhesion, fluorescent sensing, and pesticide detection based on host-guest interactions. The review also uniquely describes the properties of sub-units that make pillar[n]arenes suitable for biological applications and it provides a detailed outline for the design of new innovative pillar-like structures with specific properties to open up a new avenue for pillar[n]arene chemistry.