ABSTRACT
Garlic ability to reduce lead burden in body tissues before and during chronic lead toxicity was studied. Eighty mice were divided into 8 groups. Group D received placebo. Groups A1, A2 and A3, respectively received 500, 250 and 125 mg kg(-1) day garlic and Groups B1, B2 and B3, respectively 1/4, 1/8 and 1/16 garlic tablet kg(-1) day in first four weeks and in second four weeks they received 5 mg kg(-1) day lead acetate plus garlic or garlic tablet. Group C received placebo in first four weeks and in second four weeks they received 5 mg kg(-1) day lead acetate and placebo. Reduction in lead burden of kidney, liver, bone and blood (except for group A3) in experimental groups was significant compared with group C (p<0.05). Results showed that fresh garlic extract and garlic tablet had almost same effects on lead reduction in tissues.