Recent advance of physicochemical, structural properties, potential health benefits and application of bioactive macromolecules from Porphyra haitanensis: A review.

Porphyra haitanensis (P. haitanensis) belongs to the class Rhodophyta and the family Bangiaceae, which is a unique artificially cultivated seaweed in China, especially in the coastal areas of Fujian and Zhejiang province. P. haitanensis is rich in amino acids, mineral elements, proteins, polysaccharides, and trace elements, with proteins and polysaccharides being the main components. P. haitanensis proteins and polysaccharides have variety of biological activities, including antioxidant, anticancer, immunomodulatory, anti-allergic and anti-aging activities, among others. This review introduced and summarized the preparation, isolation and purification, phytochemistry and structural properties, and biological activities of P. haitanensis proteins and polysaccharide, as well as their biomedical and food applications. Furthermore, a thorough analysis of the current trends and perspectives on P. haitanensis bioactive macromolecules were highlighted and prospected. Hopefully, this review can provide a useful reference value for the development and application of P. haitanensis bioactive macromolecules in the field of biomedical and food in the future.

How does carrageenan cause colitis? A review.

Carrageenan is a common additive, but mounting studies have reported that it may cause or aggravate inflammation in the intestines. The safety of carrageenan remains controversial and its inflammatory mechanisms are unclear. In this review, the pathogenesis of colitis by carrageenans was discussed. We analyzed the pathogenesis of inflammatory bowel disease, followed that line of thought, the existing evidence of carrageenans causing colitis in cellular and animal models was summarized to draw its colitis pathogenesis. Two pathways were described including: 1) carrageenan changed the composition of intestinal microbiota, especially Akkermansia muciniphila, which destroyed the mucosal barrier and triggered the inflammatory immune response; and 2) carrageenan directly contacted with receptors on epithelial cells and activated the NF-κB inflammatory pathway. This review aim to provide guidance for exploring the treatment of colitis caused by carrageenan, and safe processing and utilization of carrageenan in food industry, which is worthy of study in the future.