ABSTRACT
The article presents a morphological study of UVJ removed during surgery in 110 children with stage III hydronephrosis. Morphological changes in resected UVJs indicate a predominance of sclerotic transformation accompanied by different types of dysplasia.
Subject(s)
Hydronephrosis/surgery , Ureter/abnormalities , Ureteral Obstruction/surgery , Urinary Bladder/abnormalities , Female , Humans , Hydronephrosis/congenital , Hydronephrosis/diagnosis , Hydronephrosis/etiology , Infant , Infant, Newborn , Male , Severity of Illness Index , Tomography, X-Ray Computed , Ureter/surgery , Ureteral Obstruction/congenital , Ureteral Obstruction/diagnosis , Ureteral Obstruction/etiology , Urinary Bladder/surgery , Urodynamics , UrographyABSTRACT
The one of the most common defects of the ureter-vesical segment in children is the condition, leading to a disorder of obturative function of this segment. Complications of vesicoureteral reflux include continuously recurrent pyelonephritis, reflux nephropathy. In this regard, the choice of the optimal treatment strategy based on minimal invasion is considered as one of the priorities of pediatric urology. The article presents the data obtained during the treatment of VUR in children of different ages in the Clinic of Reproductive Health FSBSI SCCH. A comparative evaluation of the results of endoscopic correction of vesicoureteral reflux depending on the kind of the bulking agent was performed. It was found that the use of endocorrection of reflux is highly effective surgical procedure, with the high number of positive results against the background of use of bulking agent "vantris". The study discriminates a group of patients with vesicoureteral reflux, intractable for endoscopic correction with cystoscopically normal structure of the orifices that allows to refer this method to the initial stage of treatment of the disease.
Subject(s)
Cystoscopy/methods , Ureteroscopy/methods , Vesico-Ureteral Reflux/surgery , Acrylic Resins/chemistry , Biocompatible Materials/chemistry , Child , Child, Preschool , Humans , Infant , Retrospective Studies , Severity of Illness Index , Treatment Outcome , Urography , Vesico-Ureteral Reflux/diagnostic imagingABSTRACT
The article deals with data of cerebral oximeter INVOS Somanetics (US) used for comparison the degree of brain oxygenation reduction, ejection fraction and stroke volume relative to age norms in children with dilated cardiomyopathy.
Subject(s)
Cardiomyopathy, Dilated/metabolism , Cerebral Cortex/metabolism , Cerebrovascular Circulation/physiology , Oxygen Consumption/physiology , Adolescent , Body Temperature/physiology , Body Weight/physiology , Carbon Dioxide/blood , Cardiomyopathy, Dilated/blood , Cardiomyopathy, Dilated/diagnostic imaging , Cardiomyopathy, Dilated/physiopathology , Child , Child, Preschool , Echocardiography , Hemoglobins/analysis , Humans , Infant , Oximetry , Oxygen/bloodABSTRACT
The results of the treatment of 38 children (6 boys and 32 girls, age 6-14 years) with chronic pyelonephritis and/or cystitis complicated with neurogenic dysfunction of the urinary bladder (NDUB) and/or vesicoureteral reflux (VUR) of the first-third degree demonstrate efficacy of intravesical electrostimulation (IVES) and adrenal magnetotherapy. IVES was conducted with high-frequency current impulses (2.2 kHz) by means of INTRASTIM attachment to the device AMUS-01-INTRAMAG in the region of the urethrovesical anastomosis via solution of the drugs for instillation. As the result of exposure to both physical factors in the presence of standard medication, NDUB symptoms alleviated (by E.L. Vishnevsky's criteria) by 59.5% against 38.1% in the control group. Dopplerographic examination of renal vessels stated a 24.3% increase in blood flow in the major renal artery in the study group against 10.5% in the control. The proposed complex pharmacological plus physiotherapeutic treatment of chronic pyelonephritis and cystitis in abnormal urodynamics resulted in a 2.2-fold decrease in the number of recurrences compared to the standard treatment.
Subject(s)
Cystitis , Electric Stimulation Therapy , Magnetic Field Therapy , Pyelonephritis , Urination Disorders , Urodynamics , Adolescent , Child , Chronic Disease , Cystitis/complications , Cystitis/physiopathology , Cystitis/therapy , Female , Humans , Male , Pyelonephritis/complications , Pyelonephritis/physiopathology , Pyelonephritis/therapy , Renal Artery/physiopathology , Renal Circulation , Urination Disorders/complications , Urination Disorders/physiopathology , Urination Disorders/therapyABSTRACT
It is demonstrated that in vitro inhibition of fibroblasts proliferation is feasible with the use of 5-fluorouracil. In stimulated growth of fibroblasts, the antiproliferative effect of 5-fluorouracil manifests even in a minimal concentration (2 mcg/ml). Recovery of fibroblast proliferative activity after elimination of 5-fluorouracil occurs in concentration under 63 mcg/ml.
Subject(s)
Cicatrix/prevention & control , Fluorouracil/therapeutic use , Immunosuppressive Agents/therapeutic use , Otorhinolaryngologic Surgical Procedures/methods , Cell Movement/drug effects , Fibroblasts/cytology , Fibroblasts/drug effects , Fluorouracil/administration & dosage , Fluorouracil/pharmacology , Immunosuppressive Agents/administration & dosage , Immunosuppressive Agents/pharmacology , In Vitro Techniques , Postoperative Period , Time FactorsABSTRACT
It is shown in vitro that fibroblast proliferation may be inhibited by 5-fluorouracil (5-Fu). In stimulated growth of the fibroblasts the 5-Fu antiproliferative effect takes place even in minimal concentration (2 mcg/ml). Fibroblastic proliferative activity recovers after elimination of 5-Fu from the medium at concentration under 63 mcg/ml.
