ABSTRACT
OBJECTIVE: To study the changes in T-lymphocyte subsets CD4+:CD8+ of peripheral blood in 29 patients with present chyluria(PPC), 29 patients with chyluria history but without chyluria (PNPC) and 38 healthy controls. METHODS: The determination of CD3+, CD4+ and CD8+ was conducted using test reagents kits. RESULTS: The percentage of CD3+, CD4+ cell were signfcantly decreased in PPS group than in PNPC and healthy control group, the ratio of CD4+/CD8+ being under 1.0. The T-lymphocyte subsets (CD3+, CD4+, CD8+) and CD4+/CD8+ ratio of both PNPC and healthy control group were all within normal range. CONCLUSION: The immune function of the patients with filarial chyluria was impaired in terms of the changes in T-lymphocyte subsets.
Subject(s)
Chyle/parasitology , Filariasis/immunology , T-Lymphocyte Subsets/immunology , Female , Filariasis/complications , Humans , Male , Middle Aged , Urine/parasitologyABSTRACT
A total of 166 cases were divided into 3 groups: group A comprised 55, group B 54 and group C 57 cases. Group A received ivermectin 0.1 mg/kg orally at a single dose, the cure rates were 100%, 3.8% and 50% for ascaris, hookworm and trichuris, infections respectively: group B received ivermectin 0.2 mg/kg orally at a single dose, the corresponding cure rates were 95.5%, 11.8% and 76.5% respectively; group C received pyrantel pamoate 10 mg/kg orally at a single dose, the corresponding cure rates were 95.5%, 29.6% and 31.6% respectively. Although the cure rates were very low for hookworm infection in both group A and B, however, a number of adult worms of Ancylostoma duodenale and Necator americanus were expelled aster medication; It indicates that ivermectin has some effects on these two species of human hookworm. Side effects were mild and transient in all groups.
Subject(s)
Intestinal Diseases, Parasitic/drug therapy , Ivermectin/therapeutic use , Nematode Infections/drug therapy , Adolescent , Adult , Ancylostoma/drug effects , Animals , Ascariasis/drug therapy , Hookworm Infections/drug therapy , Humans , Necator americanus/drug effects , Pyrantel Pamoate/therapeutic use , Trichuriasis/drug therapyABSTRACT
Both nicotinanilide hydrochloride and nicotinanilide sulfate are water-soluble, their IC50 and LC90 against Oncomelania snails being around 0.3 mg/L and 0.5 mg/L, respectively, during 24 hour exposure at 25 degrees C followed by a 7-day recovery period. The laboratory tests and field trials showed that over 90% of snails were killed within 3 days exposure at 1-2 mg/L, and that 18.4%-100% snails on moist soil were killed at over 20 degrees C, exposed to spraying dosage of 1-2 g/m2 for 1-3 days. The chemical is highly effective against snails eggs at early stage (cell stage). The LC50 of nicotinanilide to Aristichthys nobilis and Pseudorasbora parva is about 200 mg/L. The acute oral LD50 in mice is about 2 g/kg. Plants tolerate the chemical at 1-2 g/m2, but some leaves wilted at greater than or equal to 5 g/m2, dicotyledon in particular. Dermatitis has been reported in individuals frequently exposing to nicotinanilide wettable powder during massive spraying.
