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1.
J Spinal Cord Med ; : 1-15, 2024 Jul 15.
Article in English | MEDLINE | ID: mdl-39007686

ABSTRACT

CONTEXT: Individuals with spinal cord injury (SCI) require resources to prevent or self-manage complications in order to maintain optimum functioning and well-being. Rehabilitation literature suggests that mindfulness as an internal psychological resource can play a crucial role in promoting self-management and improving health and well-being. OBJECTIVES: We sought to identify and synthesize existing evidence on the role of mindfulness and mindfulness-based interventions in health and well-being outcomes among adults with SCI. METHODS: We conducted a scoping review, searching evidence across four electronic databases, CINAHL, PubMed, PsycINFO, and Web of Science, for articles published between 2000 and 2023. Additional articles were searched from the reference list of identified articles. RESULTS: Of 354 articles identified in the search, 20 were included in the scoping review. Thirteen studies were interventional in design, while the other seven included cross-sectional and qualitative designs. Some interventional studies examined mindfulness as the major component of the interventions, whereas other studies integrated mindfulness as one component of the intervention program. Overall, mindfulness and mindfulness-based interventions were associated with a range of health and well-being outcomes among individuals with SCI. CONCLUSIONS: Mindfulness and mindfulness-based interventions appear to positively impact health and well-being in adults with SCI. However, mindfulness interventions were inconsistent in terms of content, delivery frequency, and duration. It is essential to develop multifaceted, tailored mindfulness interventions utilizing a consumer-based approach and established theories of mindfulness and mindfulness-based practices for adults with SCI.

2.
Chronic Illn ; : 17423953231203731, 2023 Sep 26.
Article in English | MEDLINE | ID: mdl-37750175

ABSTRACT

OBJECTIVES: Spinal cord injury (SCI) results in mild to severe functional limitations, decreasing a person's ability to perform activities of daily living. This study aims to identify the influence of SCI characteristics and self-efficacy on functional limitations, controlling for sociodemographic factors. METHODS: Participants for this cross-sectional descriptive study included 272 persons with SCI. The participants completed questionnaires on sociodemographic information, secondary physical conditions, self-efficacy, and functional limitations, using an online Qualtrics Survey. Multiple hierarchical regression analysis was performed to test the hypothesis. RESULTS: Participants reported higher functional limitations on dressing the lower body and managing their bowels compared to other activities of daily living. The sociodemographics, injury characteristics, and self-efficacy collectively accounted for 66% variance in functional limitations. A higher level of secondary physical conditions and tetraplegia injury contributed to higher functional limitations. As hypothesized, greater self-efficacy significantly contributed to low functional limitations above and beyond sociodemographic and SCI-related variables. DISCUSSION: Functional limitations following SCI are a pervasive challange in persons with SCI. Early recognition and management of secondary conditions and implementation of psychological interventions to strengthen self-efficacy in performing activities and managing secondary complications could potentially enhance functional independence and, ultimately, quality of life in this population.

3.
Psychol Trauma ; 14(2): 229-236, 2022 Feb.
Article in English | MEDLINE | ID: mdl-34166043

ABSTRACT

OBJECTIVE: The current intensive longitudinal study aimed at examining the association between daily rumination (i.e., intrusive rumination and deliberate rumination) and posttraumatic growth (PTG) associated with the pandemic of coronavirus disease 2019 (COVID-19). METHOD: Final participants were 71 adults who were recruited from Amazon's Mechanical Turk. Participants responded to daily questions regarding ruminations they engaged in and PTG they experienced that day for a total of 29 days. RESULTS: As expected, there was no significant association between intrusive rumination and PTG, but a significant positive association was found between deliberate rumination and PTG. In addition, a person of color and those who reported as religious experienced higher levels of PTG. Furthermore, there was a significant between-person variability on the effect of deliberate rumination on PTG. CONCLUSIONS: The current study supports previous findings between rumination and PTG. It also raises the importance of acknowledging that the levels of one's PTG following deliberate rumination may differ greatly from the typical individual, indicating the need to be mindful of individual experience. (PsycInfo Database Record (c) 2022 APA, all rights reserved).


Subject(s)
COVID-19 , Posttraumatic Growth, Psychological , Adult , Ecological Momentary Assessment , Humans , Longitudinal Studies , Pandemics , SARS-CoV-2
4.
Couns Psychol ; 49(6): 907-939, 2021 Aug.
Article in English | MEDLINE | ID: mdl-34381249

ABSTRACT

Are higher levels of work-family enrichment a consequence or manifestation of certain personality traits and individuals' psychological functioning? Using random intercept cross-lagged panel models, this study examined the hypothesized stability of work-to-family enrichment (WFE) and family-to-work enrichment (FWE) over two 10-year intervals, the extent to which the within-person changes of WFE and FWE are associated with personality traits and psychological well-being (PWB), and possible gender differences. In this 20-year, longitudinal data analysis of employed adults (N=535), results indicated the robust nature of the stability of WFE/FWE. Our results suggest that personality traits were not associated with within-person change for either WFE or FWE, but PWB was associated with within-person change. Theoretically and conceptually, our findings provide strong evidence that work-family enrichment is not simply an "optimistic worldview" created by personality and well-being. The within-person results lend strong evidence that interventions that improve psychological well-being will also enhance work-family enrichment.

5.
Campbell Syst Rev ; 17(3): e1189, 2021 Sep.
Article in English | MEDLINE | ID: mdl-37051447

ABSTRACT

This review aims to synthesize the evaluation evidence for parent-engagement programs that focus on reducing juvenile truancy as the primary outcome. Delinquent behavior will be assessed as a secondary outcome when included. This objective is guided by the following research questions: (1) what is the effectiveness of parent-engagement programs for children in preschool (ages 4-5) through secondary education (ages 13-19) on primarily (a) reducing student truancy (i.e., unexcused or unauthorized absence) and secondarily (and when included) (b) reducing delinquent behaviors? (2) Is there variability in the effectiveness of parent-engagement programs across moderators such as gender, age, grade levels, settings, and contexts? (3) What factors (e.g., groups, settings, and contexts) explain the variability in the effectiveness of engagement programs in a multivariate framework?

6.
Stress Health ; 37(2): 285-296, 2021 Apr.
Article in English | MEDLINE | ID: mdl-33026151

ABSTRACT

Studies examining the association between personal growth initiative (PGI) and post-traumatic stress symptoms (PTSS) have often utilized cross-sectional research designs, and as a result, the changes in the levels of PGI and its association with the trajectory of PTSS remain unclear. The current study aimed to (1) explore the different trajectories in both PGI and PTSS and (2) examine the associations of the identified trajectories between PGI and PTSS among individuals. The final sample were 419 adults who were physically residing in the area when Hurricane Harvey made landfall on 26 August 2017. The initial data collection occurred approximately 16 months after the Hurricane, and participants were asked to participate again after 1- and 3-month later. A result from the latent growth mixture modeling revealed that for PGI, the 4-class model was the best-fitting model, and for PTSS, the 3-class model was the best-fitting model. When examining the association between the trajectories of PGI and PSS, individuals classified to higher PGI subgroups were more likely to be associated with the Recovery PTSS subgroup. The current study suggests that disaster survivors with higher PGI were more likely to recover from PTSS, raising an importance of incorporating PGI to alleviate future PTSS.


Subject(s)
Cyclonic Storms , Disasters , Posttraumatic Growth, Psychological , Stress Disorders, Post-Traumatic , Survivors , Adult , Humans , Models, Psychological , Stress Disorders, Post-Traumatic/psychology , Survivors/psychology , Survivors/statistics & numerical data
7.
Qual Life Res ; 29(12): 3191-3200, 2020 Dec.
Article in English | MEDLINE | ID: mdl-32696291

ABSTRACT

PURPOSE: The purpose of the current study was to examine the association between social cohesion and two domains of quality of life (QOL) among individuals affected by Hurricane Ike, which made landfall on September 13, 2008. Psychosocial and physical QOL were measured using the Short form of the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q-SF; Endicottn et al. in Psychopharmacol Bull 29: 321-326, 1993). METHODS: The participants were 658 survivors who participated in the Galveston Bay Recovery Study (GBRS; National Center for Disaster Mental Health Research, Galea, and Norris in Galveston Bay Recovery Study, 2008-2010, Inter-university Consortium for Political and Social Research [distributor], Ann Arbor, MI, https://doi.org/10.3886/ICPSR34801.v1 , 2016). Assessments were conducted at approximately 3, 6, and 15 months after the disaster. Longitudinal structural equation modeling was conducted to examine the association between social cohesion and both psychosocial and physical QOL at 6 and 15 months after the hurricane. RESULTS: The results revealed no significant association between social cohesion and physical QOL at either 6 or 15 months. Furthermore, no association was found between social cohesion and psychosocial QOL at 6 months. However, there was a significant positive association between social cohesion and psychosocial QOL at 15 months, even after controlling for the previous levels of posttraumatic stress and demographic variables. CONCLUSION: The current study highlights a potential effect of social cohesion on QOL, specifically the psychosocial domain, which may manifest after 6 months among survivors of a hurricane. The current results also suggest the importance of long-term programs and interventions to help survivors adjust after experiences of disaster.


Subject(s)
Cyclonic Storms/statistics & numerical data , Quality of Life/psychology , Stress Disorders, Post-Traumatic/psychology , Survivors/psychology , Adult , Cooperative Behavior , Female , Humans , Interpersonal Relations , Male , Middle Aged , Surveys and Questionnaires
8.
Stress Health ; 36(3): 365-375, 2020 Aug.
Article in English | MEDLINE | ID: mdl-32072758

ABSTRACT

The current study explored subgroups in reported personal growth initiative (PGI) and posttraumatic stress symptoms (PTSS) and examined the changes in class memberships among survivors of a transportation accident. Participants at Time 1 were 602 adults who reported directly experiencing a transportation accident within the past year (Mmonths = 6.36; SDmonths = 3.20). Of these participants, 171 adults completed the follow-up survey after 3 months (Time 2). Finite mixture modeling was conducted to identify the heterogeneity of PTSS in relation with PGI at each time point. At Time 1, a four-class model was the best-fitting model, and at Time 2, a three-class model was the best-fitting model. As hypothesized, when examined cross-sectionally, various subgroups were identified at each time point, finding subgroups with moderate to high levels of PGI but differing in their PTSS. However, when examining the longitudinal changes in class membership from Time 1 to Time 2, members of subgroups with higher PGI skills at Time 1 were more likely to be assigned to subgroups with lower PTSS at Time 2. The current study suggests a potential application of PGI skills in alleviating PTSS after a transportation accident and having a critical role in adjustment after hardship.


Subject(s)
Accidents, Traffic/psychology , Power, Psychological , Stress Disorders, Post-Traumatic/psychology , Stress Disorders, Post-Traumatic/therapy , Survivors/psychology , Adaptation, Psychological , Adult , Female , Humans , Male , Regression Analysis , Surveys and Questionnaires , Survivors/statistics & numerical data , Young Adult
9.
J Community Psychol ; 48(3): 693-708, 2020 04.
Article in English | MEDLINE | ID: mdl-31765049

ABSTRACT

The current study examined the gender differences in the interaction effect of community resources and attitudes toward seeking professional help in predicting posttraumatic stress, depression, and posttraumatic growth for female and male survivors of Hurricane Harvey. Participants were 413 adults who reported directly experiencing Hurricane Harvey, which made landfall on August 26, 2017. Purposive sampling was used to recruit participants approximately 16 months after the hurricane via an online survey. Among men, significant interaction effects of community resources and attitudes toward seeking help on posttraumatic stress, depression, and posttraumatic growth were found even after statistically controlling for age, educational attainment, income, marital status, and racial minority status. Among women, no interaction effects were found. Women with open attitudes toward seeking psychological treatment experienced higher posttraumatic stress and posttraumatic growth, and higher resources were positively associated with growth. The current study raises important implications on gender differences on community resources and attitudes toward seeking professional help after a hurricane.


Subject(s)
Depressive Disorder, Major/psychology , Patient Acceptance of Health Care/psychology , Posttraumatic Growth, Psychological , Social Welfare/psychology , Stress Disorders, Post-Traumatic/psychology , Adult , Cyclonic Storms , Depressive Disorder, Major/diagnosis , Female , Help-Seeking Behavior , Humans , Male , Middle Aged , Sex Factors , Stress Disorders, Post-Traumatic/diagnosis , Surveys and Questionnaires , Texas
10.
Int J Behav Med ; 26(5): 486-498, 2019 Oct.
Article in English | MEDLINE | ID: mdl-31309488

ABSTRACT

BACKGROUND: The minimal literature on the relation between chronic pain and both eudaimonic (EWB) and hedonic well-being (HWB) examines the relation cross-sectionally, and most studies have examined chronic pain's effect only on psychopathology. METHODS: Using a sample of 473 midlife and older adults with chronic pain, this study examined both the cross-sectional and longitudinal relations between chronic pain and EWB and HWB in addition to psychological distress. RESULTS: Multiple-group longitudinal structural equation modeling revealed that chronic pain was related significantly and negatively to EWB and HWB, and significantly and positively to distress among both men and women. When examined longitudinally, chronic pain at time 1 was associated significantly only with decreased EWB at time 2, suggesting chronic pain's risk to psychological functioning, especially because of its long-term effects on future EWB. CONCLUSIONS: Our study provides a comprehensive picture of the way chronic pain is associated both with EWB and HWB, in addition to psychological distress. Further, chronic pain may have a lasting influence on EWB, while it may have little predictive value for future HWB and psychological distress. Our study supports well-being's relevance to chronic pain research and has the potential to guide prevention strategies and treatment for chronic pain using a positive psychological framework.


Subject(s)
Chronic Pain/psychology , Adult , Aged , Aged, 80 and over , Cross-Sectional Studies , Female , Humans , Longitudinal Studies , Male , Middle Aged
11.
J Affect Disord ; 257: 345-351, 2019 10 01.
Article in English | MEDLINE | ID: mdl-31302524

ABSTRACT

BACKGROUND: The current study examined reciprocal effects of symptoms of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) among individuals affected by Hurricane Ike, which made landfall on September 13, 2008 METHODS: Participants were 658 survivors, who participated in the Galveston Bay Recovery Study (GBRS; National Center for Disaster Mental Health Research, Galea, and Norris, 2016). Assessment was conducted at 3, 6, and 15 months after the disaster. Bivariate latent change score modeling was conducted to examine the nature of the time-sequential associations between symptoms of PTSD and MDD RESULTS: Results revealed a unidirectional coupling effect from depression to change in PTSD, but unidirectional coupling effect from PTSD to change in depression was not supported. LIMITATIONS: Only linear relations of within-individual change and time-sequential associations between PTSD and depression were examined, and therefore, it precludes potential nonlinear relations between these constructs. Also, the results of the current study are limited to the studied timespan (i.e., 3 to 15 months). Lastly, other factors that could be confounding the change in PTSD symptoms were not examined, leaving a possibility of other constructs that may influence the change in future PTSD symptoms CONCLUSIONS: The current study suggests that disaster survivors with higher symptoms of depression may be at higher risk of experiencing increased PTSD symptoms even after one year, raising an importance of tailoring a treatment to alleviate depressive symptoms and to mitigate the risk of future symptoms of PTSD.


Subject(s)
Cyclonic Storms , Depression/psychology , Stress Disorders, Post-Traumatic/psychology , Adult , Depression/diagnosis , Depressive Disorder, Major/psychology , Disasters , Female , Humans , Life Change Events , Male , Middle Aged , Natural Disasters , Risk Factors , Stress Disorders, Post-Traumatic/diagnosis , Survivors/psychology , Survivors/statistics & numerical data
12.
J Affect Disord ; 246: 548-555, 2019 03 01.
Article in English | MEDLINE | ID: mdl-30599379

ABSTRACT

BACKGROUND: Current methods for treating depressive disorders ineffectively treat large portions of patients. We need to identify malleable factors that predict treatment outcome and can be modified prior to or concurrently with treatment to enhance outcomes. We examined personal growth initiative (PGI) as a malleable predictor of treatment outcome for depressed patients in partial hospital treatment. METHODS: Archival data were extracted from medical records of 521 adult patients with depression diagnoses (67.2% women) in a partial hospital program (2008 - 2010). Demographic data and admission and discharge scores for depression and PGI were extracted. ANCOVA assessed the extent to which reliable or clinically significant change in PGI predicted level of depression at discharge, controlling for admission depression levels. RESULTS: PGI and depression were significantly correlated at admission. PGI scores increased significantly from admission to discharge. Reliable and clinically significant improvement in PGI each significantly, uniquely, and negatively predicted depression at discharge, adjusting for admission depression. LIMITATIONS: The correlational nature of the longitudinal design precludes definitive statements regarding causality. A large portion of the initial sample was dropped due to substantial missing data, yielding the final N = 521. Dropped patients had higher levels of depression at discharge and increased likelihood of leaving treatment against medical advice, raising concerns about potential other, unmeasured differences. CONCLUSIONS: Our findings confirm the utility of PGI as a malleable predictor of treatment outcome for depressed patients in partial hospital treatment and may have implications for using PGI-based interventions to enhance treatment outcomes.


Subject(s)
Depression/therapy , Depressive Disorder/therapy , Psychotherapy , Adult , Depression/psychology , Depressive Disorder/psychology , Female , Hospitalization , Humans , Inpatients/psychology , Male , Middle Aged , Treatment Outcome
13.
J Am Coll Health ; 66(5): 350-359, 2018 07.
Article in English | MEDLINE | ID: mdl-29405871

ABSTRACT

OBJECTIVE: This study examined the inconsistent relationship found between personal growth initiative (PGI) and posttraumatic stress symptoms (PTSS) by exploring potential subgroups. In addition, after identifying the subgroups, potential predictors of these subgroups were examined. PARTICIPANTS: Participants were 534 undergraduate students who experienced a potentially traumatic event (PTE). Data collection occurred from March 2013 to December 2014. METHODS: Because this was a preliminary study, archival data was used. Participants consisted of students who experienced a PTE within the past three years. RESULTS: Latent profile analysis indicated a five-class model as the best-fitting model. Direct exposure and intentionality of the event were significant predictors of class membership; length of time since event and gender did not predict class membership. CONCLUSIONS: The current study provides a potential explanation of the inconsistent results between PGI and PTSS and also highlights the importance of acknowledging subgroups when utilizing PGI after a PTE.


Subject(s)
Power, Psychological , Resilience, Psychological , Stress Disorders, Post-Traumatic/psychology , Stress Disorders, Post-Traumatic/therapy , Students/psychology , Survivors/psychology , Wounds and Injuries/psychology , Adult , Female , Humans , Male , Students/statistics & numerical data , Survivors/statistics & numerical data , Universities/statistics & numerical data , Young Adult
14.
J Clin Psychol ; 73(9): 1126-1145, 2017 Sep.
Article in English | MEDLINE | ID: mdl-27922720

ABSTRACT

OBJECTIVES: The current study examined whether various types of rumination are distinguishable and the effects of personal growth initiative (PGI) on posttraumatic growth, posttraumatic stress, and depression through adaptive and maladaptive rumination. METHOD: Sample included 292 college students who experienced a potentially traumatic event (PTE). RESULTS: Intrusive and deliberative rumination were found to be distinct factors. However, brooding and reflection, thought to be separate aspects of depression, were a single factor. PGI was positively associated with growth and negatively associated with depression for both genders, and a negative relationship was found between PGI and posttraumatic stress among women. Indirect effects of PGI were found on posttraumatic stress and growth through different forms of rumination. These relations did not change after including the covariates (i.e., time since the trauma, direct exposure, and intentional harm). CONCLUSION: The study provides new insight integrating rumination from the depression literature in the context of trauma and a potential benefit in applying PGI in alleviating pathology after a PTE and facilitating growth.


Subject(s)
Adaptation, Psychological/physiology , Depression/physiopathology , Psychological Trauma/physiopathology , Rumination, Cognitive/physiology , Stress Disorders, Post-Traumatic/physiopathology , Adolescent , Adult , Female , Humans , Male , Students , Universities , Young Adult
15.
J Am Coll Health ; 64(7): 527-34, 2016 10.
Article in English | MEDLINE | ID: mdl-27176777

ABSTRACT

OBJECTIVE: This study explored the extent to which personal growth initiative (PGI) may predict posttraumatic stress and growth in student service members/veterans (SSM/V). PARTICIPANTS: Participants were 136 SSM/V (79% men) representing multiple branches of the armed forces. Forty-four percent of participants reported having combat experience. METHODS: Data collection occurred from October 2013 to February 2014. Data were collected via a Web-based survey that included demographics and measures of personal growth initiative, posttraumatic stress, posttraumatic growth, and perceived social support. RESULTS: Results indicated that PGI is not a unique predictor of posttraumatic stress but is a unique predictor of higher levels of posttraumatic growth. PGI appears to be at least as important as perceived social support in facilitating growth in SSM/V. CONCLUSIONS: This study provides further evidence for PGI's potential to facilitate growth after a traumatic event.


Subject(s)
Stress Disorders, Post-Traumatic/psychology , Students/psychology , Veterans/psychology , Adult , Female , Humans , Male , Resilience, Psychological , Social Support , Surveys and Questionnaires , Universities , Young Adult
16.
Soc Sci Med ; 156: 29-38, 2016 May.
Article in English | MEDLINE | ID: mdl-27017088

ABSTRACT

RATIONALE: This study investigates the intrapersonal and interpersonal factors and processes that are associated with patient forgiveness of a provider in the aftermath of a harmful medical error. OBJECTIVE: This study aims to examine what antecedents are most predictive of patient forgiveness and non-forgiveness, and the extent to which social-cognitive factors (i.e., fault attributions, empathy, rumination) influence the forgiveness process. Furthermore, the study evaluates the role of different disclosure styles in two different forgiveness models, and measures their respective causal outcomes. METHODS: In January 2011, 318 outpatients at Wake Forest Baptist Medical Center in the United States were randomly assigned to three hypothetical error disclosure vignettes that operationalized verbally effective disclosures with different nonverbal disclosure styles (i.e., high nonverbal involvement, low nonverbal involvement, written disclosure vignette without nonverbal information). All patients responded to the same forgiveness-related self-report measures after having been exposed to one of the vignettes. RESULTS: The results favored the proximity model of interpersonal forgiveness, which implies that factors more proximal in time to the act of forgiving (i.e., patient rumination and empathy for the offender) are more predictive of forgiveness and non-forgiveness than less proximal factors (e.g., relationship variables and offense-related factors such as the presence or absence of an apology). Patients' fault attributions had no effect on their forgiveness across conditions. The results evidenced sizeable effects of physician nonverbal involvement-patients in the low nonverbal involvement condition perceived the error as more severe, experienced the physician's apology as less sincere, were more likely to blame the physician, felt less empathy, ruminated more about the error, were less likely to forgive and more likely to avoid the physician, reported less closeness, trust, and satisfaction but higher distress, were more likely to change doctors, less compliant, and more likely to seek legal advice. CONCLUSION: The findings of this study imply that physician nonverbal involvement during error disclosures stimulates a healing mechanism for patients and the physician-patient relationship. Physicians who disclose a medical error in a nonverbally uninvolved way, on the other hand, carry a higher malpractice risk and are less likely to promote healthy, reconciliatory outcomes.


Subject(s)
Attitude to Health , Forgiveness , Medical Errors , Nonverbal Communication/psychology , Patients/psychology , Physician-Patient Relations , Truth Disclosure , Adolescent , Adult , Aged , Aged, 80 and over , Empirical Research , Female , Humans , Male , Malpractice/legislation & jurisprudence , Middle Aged , Patients/statistics & numerical data , United States , Videotape Recording , Young Adult
17.
J Couns Psychol ; 62(3): 537-544, 2015 Jul.
Article in English | MEDLINE | ID: mdl-25915464

ABSTRACT

This study tested the cross-cultural validity of scores on the Personal Growth Initiative Scale-II (PGIS-II; Robitschek et al., 2012) with Hispanic, African American, and European American community samples. Multigroup confirmatory factor analyses were performed on data from 218 Hispanics, 129 African Americans, and 552 European Americans to examine measurement equivalence among these groups. Measurement invariance of the PGIS-II was established with the original 4 factors of readiness for change, planfulness, using resources, and intentional behavior. These findings suggest the PGIS-II can be administered across these groups and provide meaningful comparisons and interpretations. All samples yielded good internal consistency estimates. The African American sample reported higher means than Hispanic and European American samples for all subscale and total mean scores, and Hispanics scored higher in planfulness, readiness for change, and total score than European Americans, indicating potential cultural factors influencing the scores. Implications for research and clinical practice are discussed.


Subject(s)
Adaptation, Psychological , Black or African American/psychology , Cross-Cultural Comparison , Hispanic or Latino/psychology , White People/psychology , Adult , Black or African American/ethnology , Ethnicity/ethnology , Ethnicity/psychology , Factor Analysis, Statistical , Female , Hispanic or Latino/ethnology , Humans , Male , Psychometrics/methods , United States/ethnology , White People/ethnology , Young Adult
18.
Clin Exp Pharmacol Physiol ; 32(9): 757-60, 2005 Sep.
Article in English | MEDLINE | ID: mdl-16173933

ABSTRACT

1. In the present study, we tested the effect of seed coat extract from black soybeans on eight-arm radial maze performance in rats. 2. Rats were fed a diet containing 5% seed coat extract from black soybeans or a normal diet for 40 days. 3. One week after the start of feeding, rats were tested for learning ability related to two types of memory, reference memory and working memory, with a partially (four of eight) baited eight-arm radial maze. 4. A significant decrease in the total number of errors was observed 30 (mean value of five trials of 26-30 days) and 35 days (30-35 days) after the intake of the diet containing seed coat extract compared with the control group. In addition, the mean number of days taken to reach this criterion was significantly decreased after the intake of the diet containing the seed coat extract. 5. The number of reference memory errors was significantly decreased 30 and 35 days after the intake of the diet containing seed coat extract. However, no significant decrease was observed in the number of working memory errors. 6. From these results, it is concluded that the intake of seed coat extract from black soybeans effectively enhances memory and learning ability, especially long-term memory, in rats.


Subject(s)
Glycine max/chemistry , Learning/drug effects , Memory/drug effects , Seeds/chemistry , Animals , Male , Plant Extracts/chemistry , Plant Extracts/pharmacology , Rats , Rats, Wistar
19.
Brain Res ; 1023(1): 121-5, 2004 Oct 08.
Article in English | MEDLINE | ID: mdl-15364026

ABSTRACT

The participation of histaminergic H(1) and noradrenergic alpha(1) receptors in orexin A-induced wakefulness was studied by examining the sleep-wakefulness cycle in rats. Intracerebroventricular infusion of orexin A (1 nmol) caused an increase in the wakefulness state, while non-rapid eye movement sleep (NREM sleep) and rapid eye movement sleep (REM sleep) states were decreased. Prazosin (150 nmol) showed no significant antagonistic effect on the orexin A-induced increase in the wakefulness state and decrease in NREM and REM sleep. On the contrary, pyrilamine (150 nmol) was effective in antagonizing orexin A-induced increase in wakefulness and decrease in NREM sleep. When prazosin (150 nmol) and pyrilamine (150 nmol) were simultaneously perfused into the lateral ventricle, an almost complete antagonistic effect was observed with the increase in the wakefulness state and decrease in NREM sleep. Orexin A (1 nmol) caused a significant decrease in the histamine contents of the cortex, hippocampus and hypothalamus, whereas noradrenaline contents were decreased only in the hypothalamus. From these results, we concluded that the arousal effect induced by orexin A occurs through histaminergic H(1) and noradrenergic alpha(1) receptors, although participation of the H(1) receptor was more important than the alpha(1) receptor.


Subject(s)
Intracellular Signaling Peptides and Proteins/pharmacology , Neuropeptides/pharmacology , Receptors, Adrenergic, alpha-1/physiology , Receptors, Histamine H1/physiology , Wakefulness/drug effects , Animals , Histamine/metabolism , Male , Norepinephrine/metabolism , Orexin Receptors , Orexins , Rats , Rats, Wistar , Receptors, G-Protein-Coupled , Receptors, Neuropeptide , Sleep/drug effects , Sleep/physiology , Wakefulness/physiology
20.
Eur J Pharmacol ; 494(2-3): 161-5, 2004 Jun 28.
Article in English | MEDLINE | ID: mdl-15212970

ABSTRACT

The present study was performed to examine the sedative effects of second-generation histamine H(1) receptor antagonist using power spectrum analysis in the rat. Similar to ketotifen, olopatadine caused a decrease in sleep latency at a dose of 50 mg/kg, while epinastine and cetirizine showed no significant effect even at a dose of 50 mg/kg. On the other hand, no significant difference was observed in the total times of wakefulness, non-rapid eye movement sleep and rapid eye movement sleep by any drugs used in the experiments. The number of sleep phases and interval between sleep phases were also unchanged by these drugs. Ketotifen and olopatadine inhibited [(3)H]mepyramine binding to rat brain homogenates in parallel with a decrease in sleep latency. No significant effect was observed with epinastine and cetirizine on [(3)H]mepyramine binding. These findings suggest that the differences in the central nervous system (CNS) depressant effect observed in second generation H(1) receptor antagonists may be due to their liability to penetrate into the CNS.


Subject(s)
Histamine H1 Antagonists/pharmacology , Sleep/drug effects , Wakefulness/drug effects , Animals , Binding, Competitive/drug effects , Brain/metabolism , Electroencephalography/drug effects , Electromyography/drug effects , Histamine H1 Antagonists/metabolism , In Vitro Techniques , Male , Pyrilamine/metabolism , Rats , Rats, Wistar
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