Use of a wearable device to compare subjective and objective fatigue in lung cancer patients and cancer-free controls.

PURPOSE: The study evaluates the use of heart rate variability (HRV), a measure of autonomic nervous system (ANS) modulation via wearable smart bands, to objectively assess cancer-related fatigue (CRF) levels. It aims to enhance understanding of fatigue by distinguishing between LF/HF ratios and LF/HF disorder ratios through HRV and photoplethysmography (PPG), identifying them as potential biomarkers. METHODS: Seventy-one lung cancer patients and 75 non-cancer controls wore smart bands for one week. Fatigue was assessed using Brief Fatigue Inventory, alongside sleep quality and daily interference. HRV parameters were analyzed to compare groups. RESULTS: Cancer patients showed higher fatigue and interference levels than controls (64.8% vs. 54.7%). Those with mild fatigue had elevated LF/HF disorder ratios during sleep (40% vs. 20%, P = 0.01), similar to those with moderate to severe fatigue (50% vs. 20%, P = 0.01), indicating more significant autonomic dysregulation. Notably, mild fatigue patients had higher mean LF/HF ratios than controls (1.9 ± 1.34 vs. 1.2 ± 0.6, P = 0.01), underscoring the potential of disorder ratios in signaling fatigue severity. CONCLUSIONS: Utilizing wearable smart bands for HRV-based analysis is feasible for objectively assess CRF levels in cancer patients, especially during sleep. By distinguishing between LF/HF ratios and LF/HF disorder ratios, our findings suggest that wearable technology and detailed HRV analysis offer promising avenues for real-time fatigue monitoring. This approach has the potential to significantly improve cancer care by providing new methods for managing and intervening in CRF, particularly with a focus on autonomic dysregulation as a crucial factor.

Game Fun Prediction Based on Frequency Domain Physiological Signals: Observational Study.

Traditionally, the subjective questionnaire collected from game players is regarded as a primary tool to evaluate a video game. However, the subjective evaluation result may vary due to individual differences, and it is not easy to provide real-time feedback to optimize the user experience. This paper aims to develop an objective game fun prediction system. In this system, the wearables with photoplethysmography (PPG) sensors continuously measure the heartbeat signals of game players, and the frequency domain heart rate variability (HRV) parameters can be derived from the inter-beat interval (IBI) sequence. Frequency domain HRV parameters, such as low frequency(LF), high frequency(HF), and LF/HF ratio, highly correlate with the human's emotion and mental status. Most existing works on emotion measurement during a game adopt time domain physiological signals such as heart rate and facial electromyography (EMG). Time domain signals can be easily interfered with by noises and environmental effects. The main contributions of this paper include (1) regarding the curve transition and standard deviation of LF/HF ratio as the objective game fun indicators and (2) proposing a linear model using objective indicators for game fun score prediction. The self-built dataset in this study involves ten healthy participants, comprising 36 samples. According to the analytical results, the linear model's mean absolute error (MAE) was 4.16%, and the root mean square error (RMSE) was 5.07%. While integrating this prediction model with wearable-based HRV measurements, the proposed system can provide a solution to improve the user experience of video games.

Cancer-related fatigue classification based on heart rate variability signals from wearables.

Background: Cancer-related fatigue (CRF) is the most distressing side effect in cancer patients and affects the survival rate. However, most patients do not report their fatigue level. This study is aimed to develop an objective CRF assessment method based on heart rate variability (HRV). Methods: In this study, patients with lung cancer who received chemotherapy or target therapy were enrolled. Patients wore wearable devices with photoplethysmography that regularly recorded HRV parameters for seven consecutive days and completed the Brief Fatigue Inventory (BFI) questionnaire. The collected parameters were divided into the active and sleep phase parameters to allow tracking of fatigue variation. Statistical analysis was used to identify correlations between fatigue scores and HRV parameters. Findings: In this study, 60 patients with lung cancer were enrolled. The HRV parameters including the low-frequency/high-frequency (LF/HF) ratio and the LF/HF disorder ratio in the active phase and the sleep phase were extracted. A linear classifier with HRV-based cutoff points achieved correct classification rates of 73 and 88% for mild and moderate fatigue levels, respectively. Conclusion: Fatigue was effectively identified, and the data were effectively classified using a 24-h HRV device. This objective fatigue monitoring method may enable clinicians to effectively handle fatigue problems.

Ackerman Unmanned Mobile Vehicle Based on Heterogeneous Sensor in Navigation Control Application.

With the advancement of science and technology, the development and application of unmanned mobile vehicles (UMVs) have emerged as topics of crucial concern in the global industry. The development goals and directions of UMVs vary according to their industrial uses, which include navigation, autonomous driving, and environmental recognition; these uses have become the priority development goals of researchers in various fields. UMVs employ sensors to collect environmental data for environmental analysis and path planning. However, the analysis function of a single sensor is generally affected by natural environmental factors, resulting in poor identification results. Therefore, this study introduces fusion technology that employs heterogeneous sensors in the Ackerman UMV, leveraging the advantages of each sensor to enhance accuracy and stability in environmental detection and identification. This study proposes a fusion technique involving heterogeneous imaging and LiDAR (laser imaging, detection, and ranging) sensors in an Ackerman UMV. A camera is used to obtain real-time images, and YOLOv4-tiny and simple online real-time tracking are then employed to detect the location of objects and conduct object classification and object tracking. LiDAR is simultaneously used to obtain real-time distance information of detected objects. An inertial measurement unit is used to gather odometry information to determine the position of the Ackerman UMV. Static maps are created using simultaneous localization and mapping. When the user commands the Ackerman UMV to move to the target point, the vehicle control center composed of the robot operating system activates the navigation function through the navigation control module. The Ackerman UMV can reach the destination and instantly identify obstacles and pedestrians when in motion.

Bed-Exit Behavior Recognition for Real-Time Images within Limited Range.

In the context of behavior recognition, the emerging bed-exit monitoring system demands a rapid deployment in the ward to support mobility and personalization. Mobility means the system can be installed and removed as required without construction; personalization indicates human body tracking is limited to the bed region so that only the target is monitored. To satisfy the above-mentioned requirements, the behavior recognition system aims to: (1) operate in a small-size device, typically an embedded system; (2) process a series of images with narrow fields of view (NFV) to detect bed-related behaviors. In general, wide-range images are preferred to obtain a good recognition performance for diverse behaviors, while NFV images are used with abrupt activities and therefore fit single-purpose applications. This paper develops an NFV-based behavior recognition system with low complexity to realize a bed-exit monitoring application on embedded systems. To achieve effectiveness and low complexity, a queueing-based behavior classification is proposed to keep memories of object tracking information and a specific behavior can be identified from continuous object movement. The experimental results show that the developed system can recognize three bed behaviors, namely off bed, on bed and return, for NFV images with accuracy rates of 95~100%.

Measurement of Cancer-Related Fatigue Based on Heart Rate Variability: Observational Study.

BACKGROUND: Cancer-related fatigue is a serious side effect of cancer, and its treatment can disrupt the quality of life of patients. Clinically, the standard method for assessing cancer-related fatigue relies on subjective experience retrieved from patient self-reports, such as the Brief Fatigue Inventory (BFI). However, most patients do not self-report their fatigue levels. OBJECTIVE: In this study, we aim to develop an objective cancer-related fatigue assessment method to track and monitor fatigue in patients with cancer. METHODS: In total, 12 patients with lung cancer who were undergoing chemotherapy or targeted therapy were enrolled. We developed frequency-domain parameters of heart rate variability (HRV) and BFI based on a wearable-based HRV measurement system. All patients completed the BFI-Taiwan version questionnaire and wore the device for 7 consecutive days to record HRV parameters such as low frequency (LF), high frequency (HF), and LF-HF ratio (LF-HF). Statistical analysis was used to map the correlation between subjective fatigue and objective data. RESULTS: A moderate positive correlation was observed between the average LF-HF ratio and BFI in the sleep phase (ρ=0.86). The mapped BFI score derived by the BFI mapping method could approximate the BFI from the patient self-report. The mean absolute error rate between the subjective and objective BFI scores was 3%. CONCLUSIONS: LF-HF is highly correlated with the cancer-related fatigue experienced by patients with lung cancer undergoing chemotherapy or targeted therapy. Beyond revealing fatigue levels objectively, continuous HRV recordings through the photoplethysmography watch device and the defined parameters (LF-HF) can define the active phase and sleep phase in patients with lung cancer who undergo chemotherapy or targeted chemotherapy, allowing a deduction of their sleep patterns.