Longitudinal associations between adolescents' sleep and adjustment: Respiratory sinus arrhythmia as a moderator.

Sleep and autonomic nervous system functioning are important bioregulatory systems. Poor sleep and low baseline respiratory sinus arrhythmia (RSA), a measure of parasympathetic nervous system activity, are associated with externalizing behaviors and depressive symptoms in youth. Rarely, however, have measures of these systems been examined conjointly. The present study examined baseline RSA (RSA-B) as a moderator of longitudinal relations between adolescent sleep and adjustment. Participants were 256 adolescents (52% girls, 66% White/European American, 34% Black/African American) from small towns and surrounding rural communities in the southeastern United States. Sleep (minutes, efficiency, variability in minutes and efficiency) was assessed at age 15 via actigraphs across seven nights. RSA-B was derived from electrocardiogram data collected at rest. Adolescents self-reported externalizing problems and depressive symptoms at ages 15 and 17. Controlling for age 15 adjustment, findings generally demonstrated that sleep predicted age 17 adjustment particularly at higher (rather than lower) levels of RSA-B, such that adolescents with good sleep (more minutes and lower variability) and high RSA-B were at lowest risk for maladjustment. The results highlight the value of examining multiple bioregulatory processes conjointly and suggest that promoting good sleep habits and regulation of physiological arousal should support adolescent adjustment.

Racial disparities in adolescent sleep duration: Physical activity as a protective factor.

Objectives: Short sleep duration compromises adolescents' functioning across many domains, yet risk for short sleep is not evenly distributed among youth in the United States. Significant Black-White disparities in sleep duration have been observed, with Black/African American youth on average sleeping fewer minutes per night than their White/European American peers. However, not all Black adolescents have short sleep, and identification of moderators of effects, including protective and vulnerability factors in the association between race/ethnicity and sleep duration, is warranted. We examined whether engagement in physical activity attenuates the gap in sleep duration between Black and White teenagers. Method: A sample of 246 adolescents (Mage = 15.79 years; 32.9% Black, 67.1% White) reported on their physical activity and participated in 1 week of at-home actigraphic sleep assessment, which was used to derive sleep duration (minutes scored as asleep from sleep onset to wake time). Results: At higher levels of physical activity, relatively long sleep duration was observed for all youth regardless of their race/ethnicity. However, at lower levels of physical activity, an association emerged between race and sleep minutes, illustrating that youth most at risk for shorter sleep were Black adolescents with lower physical activity. Conclusions: Findings suggest that for Black adolescents, physical activity is a protective factor against short sleep duration and, conversely, low physical activity is a vulnerability factor. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Trajectories of sleep problems in childhood: associations with mental health in adolescence.

STUDY OBJECTIVES: We examined initial levels (intercepts) of sleep-wake problems in childhood and changes in sleep-wake problems across late childhood (slopes) as predictors of externalizing behavior problems, depressive symptoms, and anxiety in adolescence. To ascertain the unique effects of childhood sleep problems on adolescent mental health, we controlled for both childhood mental health and adolescent sleep problems. METHODS: Participants were 199 youth (52% boys; 65% White/European American, 35% Black/African American). Sleep-wake problems (e.g. difficulty sleeping and waking up in the morning) were assessed during three time points in late childhood (ages 9, 10, and 11) with self-reports on the well-established School Sleep Habits Survey. At age 18, multiple domains of mental health (externalizing behavior problems, depressive symptoms, and anxiety) and sleep-wake problems were assessed. RESULTS: Latent growth curve modeling revealed that children with higher levels of sleep-wake problems at age 9 had consistently higher levels of such problems between ages 9 and 11. The initial level of sleep-wake problems at age 9 predicted externalizing behaviors, depressive symptoms, and anxiety at age 18, controlling for mental health in childhood and concurrent sleep-wake problems in adolescence. The slope of sleep-wake problems from ages 9 to 11 did not predict age 18 mental health. CONCLUSIONS: Youth who had higher sleep-wake problems during late childhood had higher levels of mental health problems in adolescence even after controlling for childhood mental health and concurrent sleep-wake problems. Findings illustrate that childhood sleep problems may persist and predict adolescent mental health even when potentially confounding variables are rigorously controlled.

Sleep and development in adolescence in the context of socioeconomic disadvantage.

INTRODUCTION: Sleep problems are associated with negative developmental outcomes in youth, and identification of vulnerability and protective factors is needed to explicate for whom and under which conditions adolescents may be most at risk. Towards this end, we examined socio-economic status (SES) as a moderator of associations between multiple sleep parameters and adolescents' socio-emotional adjustment and cognitive functioning. METHODS: Participants were 272 adolescents (M age = 17.3 years; 49% girls) and their parents, residing in the Southeastern U.S.A. The sample was socioeconomically diverse and included 41% Black/African American and 59% White/European American youth. Using a cross-sectional design, adolescents' sleep was assessed with actigraphy (total sleep minutes; efficiency indicated by % of time asleep from sleep onset to wake time) and self-reports of sleep quality (sleep-wake problems). Mothers reported on youths' internalizing and externalizing symptoms, and cognitive functioning was assessed with a standardized test battery. RESULTS: Moderation effects were found and illustrated that, for youth from families with lower SES, shorter and less efficient sleep and subjective sleep problems were associated with higher levels of internalizing and externalizing symptoms as well as lower cognitive performance. Conversely, longer and better-quality sleep protected against socio-emotional and cognitive difficulties otherwise observed for socioeconomically disadvantaged youth. Fewer relations between sleep and adjustment emerged for adolescents from families with higher SES. CONCLUSIONS: Results reinforce a growing literature indicating that the relation between sleep and adjustment is stronger for youth from families with lower SES, who may especially benefit from better sleep.

Linear and Nonlinear Associations between Sleep and Adjustment in Adolescence.

BACKGROUND & OBJECTIVES: A growing body of work supports linear associations between sleep and socioemotional adjustment in adolescence. However, associations between sleep and adjustment are not necessarily linear and investigations of nonlinear effects are scarce. This study examined linear and nonlinear relations between several sleep-wake parameters and externalizing behavior and internalizing symptoms in adolescence, and assessed the role of adolescent sex as a moderator of effects. PARTICIPANTS: Participants were high school students (N = 180; M age = 17.49, SD = .62; 59% female; 68% White/European American, 32% Black/African American) from a wide range of socio-economic backgrounds living in semirural communities and small towns in Alabama. METHODS: Sleep-wake parameters were indexed by actigraphy-derived sleep minutes and adolescents' reports on morningness-eveningness (circadian preference), sleep-wake problems (sleep quality), and sleepiness. Adolescents completed questionnaires on externalizing behaviors and internalizing symptoms. RESULTS: Controlling for sleep duration, a higher preference for eveningness and poor sleep quality were associated in a linear fashion with increased externalizing and internalizing symptoms. Nonlinear relations between sleepiness and internalizing symptoms emerged with pronounced sex-related effects, including somewhat delayed accelerating relations for males and rapidly accelerating associations that tended to plateau for females. CONCLUSIONS: Results illustrate the importance of examining multiple sleep-wake and adjustment variables as well as linear and nonlinear associations.

Dynamic patterns of marital conflict: Relations to trajectories of adolescent adjustment.

The deleterious effects of marital conflict on youth outcomes are well-documented in both cross-sectional and longitudinal studies. To date, longitudinal studies have focused on repeated measures of youths' outcomes and the temporal dynamics of marital conflict have largely been ignored. Marital conflict changes over time as contextual and relationship characteristics change, and these patterns of change may provide unique predictive power in accounting for differences in youth outcomes. This study provides a novel exploration of an old idea by focusing on dynamic patterns of marital conflict in predicting trajectories of adolescents' adjustment. All variables were measured at ages 16, 17, and 18 with 252 adolescents (53% female) enrolled in the longitudinal Family Stress and Youth Development Study. Latent growth curve models with latent variable interactions were used to determine whether marital conflict at age 16 (intercept), change over time in marital conflict (slope), and the intercept-slope interaction predicted change over time in adolescent internalizing and externalizing symptoms and levels of internalizing and externalizing symptoms at age 18. Youth exposed to high and increasing levels of marital conflict reported high and stable levels of internalizing and externalizing symptoms across adolescence. Adolescents exposed to low and decreasing levels of marital conflict had consistently fewer symptoms. Furthermore, exposure to initially low but increasing levels of marital conflict was associated with increases in problems across adolescence, which contrasted with findings for youth with initially high marital conflict exposure that decreased over time. Findings are discussed in relation to both conceptual and methodological advances. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Parenting, deviant peer affiliation, and externalizing behavior during adolescence: processes conditional on sympathetic nervous system reactivity.

BACKGROUND: This study examined associations between permissive parenting, deviant peer affiliations, and externalizing behavior across mid to late adolescence in a plausible indirect effects model of change over time with deviant peer affiliation serving as the mediator. We also evaluated potential conditional indirect effects wherein these relationships may be moderated by sex and sympathetic nervous system (SNS) activity, indexed by skin conductance level (SCL) reactivity. METHOD: Participants included 242 community-sampled adolescents (M = 15.79 years; 48% boys; 66% European American, 34% African American) with two additional longitudinal assessments lagged by 1 year. Permissive parenting, SCL reactivity, and sex were considered as time invariant predictors of repeated measures of deviant peer affiliation and externalizing behavior in latent growth models that tested whether any of the direct or indirect associations were conditional on sex or SCL reactivity. RESULTS: Evidence was found for indirect effects of permissive parenting on externalizing behavior via deviant peer affiliation, but only for males with lower SCL reactivity to stress. Additionally, these effects were found on latent intercepts, but not slopes indexing change over time, perhaps reflecting established individual differences in relationships among these variables. CONCLUSIONS: Findings are discussed in the context of biosocial models of adolescent development and risk factors that may inform interventions for vulnerable youth.

Sleepiness as a pathway linking race and socioeconomic status with academic and cognitive outcomes in middle childhood.

OBJECTIVES: This study examined self-reported sleepiness as a pathway of effects underlying racial and socioeconomic disparities in children's academic and cognitive performance. DESIGN: The study design was longitudinal, and path modeling was used to test study hypotheses. SETTING: Data were collected from participants residing in semirural communities and small towns surrounding Auburn, AL. PARTICIPANTS: Children (N = 282; 52% boys) participated in the study when they were 9 (M = 9.44, SD = .71) and 11 (M = 11.33, SD = .69) years old. The sample was 65% White/European American and 35% Black/African American. The majority of the children (63%) were living at or below the poverty line. MEASUREMENTS: At age 9, children reported on their daytime sleepiness over the prior 2 weeks. At ages 9 and 11, children completed cognitive assessments in the laboratory, teachers reported on children's academic functioning, and schools provided state (Alabama) standardized test scores. RESULTS: African American children and children from lower socioeconomic status homes reported greater sleepiness. Greater sleepiness, in turn, predicted lower academic functioning, cognitive performance, and Alabama standardized test scores. Sleepiness was a significant intervening variable, but not a mediator, in these pathways. Race was a stronger predictor of sleepiness than socioeconomic status when both were entered in the same model. CONCLUSIONS: Results highlight sleepiness as a pathway of effects linking race and socioeconomic status to academic and cognitive outcomes. Psychoeducation targeting sleepiness for African American and lower-socioeconomic status children may be beneficial for boosting achievement.

Infant Sleeping Arrangements, Social Criticism, and Maternal Distress in the First Year.

The present study examined differences in social criticism and maternal distress and in household, maternal, and infant characteristics between families who co-slept with their infants beyond 6 months and those who moved their infants to a separate room by 6 months. Data for infant sleeping arrangements, preferences for their sleeping arrangement choices, criticism, depressive and anxiety symptoms, and worries about infant sleep were collected from 103 European American mothers during the infant's first year. Mothers who co-slept with their infants beyond 6 months (persistent co-sleepers) were more likely than mothers who moved their infants to solitary sleep by 6 months to receive criticism and report depression and worry about infants' sleep behavior, even after controlling for preference for the sleep arrangement they used. Interestingly, criticism was associated with maternal depression and worries only for persistent co-sleeping mothers. Further, these mothers had lower income, reported greater space constraints, were younger, single, or unemployed, less likely to have a Bachelor's degree, and more likely to have infants with greater negative affectivity or problematic night waking, compared to mothers of solitary sleeping infants. Adherence to cultural norms regarding infant sleeping arrangements may be a strong predictor of social criticism and maternal well-being.

Sleep arrangements, parent-infant sleep during the first year, and family functioning.

The present longitudinal study addressed the ongoing debate regarding the benefits and risks of infant-parent cosleeping by examining associations between sleep arrangement patterns across the first year of life and infant and parent sleep, marital and family functioning, and quality of mothers' behavior with infants at bedtime. Patterns of infant sleep arrangements across the infants' first year were derived from information obtained from 139 families at 1, 3, 6, 9, and 12 months of infant age in a central Pennsylvania sample. Linkages between these patterns and parent-infant sleep, marital and coparenting stress, and maternal behavior at bedtime (from video-recordings) were assessed. Compared with families whose infants were solitary sleepers by 6 months, persistent cosleeping was associated with sleep disruption in mothers but not in infants, although mothers in persistent cosleeping arrangements reported that their infants had more frequent night awakenings. Persistent cosleeping was also associated with mother reports of marital and coparenting distress, and lower maternal emotional availability with infants at bedtime (from home observations). Persistent cosleeping appeared to be a marker of, though not necessarily a cause of, heightened family stress, although the present design did not enable strong tests of causal processes, and results may be particular to cultures that are not supportive of cosleeping. Findings are discussed in terms of cultural contexts of infant sleep and the need for further investigations into the role of the health of the family system in influencing how parents structure infant sleep. (PsycINFO Database Record

Marital and emotional adjustment in mothers and infant sleep arrangements during the first six months.

Although parents' structuring of infant sleep is complexly determined, little attention has been given to parents' marital and personal adjustment in shaping sleep arrangement choices. Linkages were examined between infant sleep arrangements at 1 and 6 months and mothers' marital adjustment, co-parenting quality, and depressive symptoms. The final study sample was composed of 149 families (53% girl infants, 86% European American). Bed sharing mothers had lower co-parenting quality, and, at 6 months, more depressive symptoms than mothers of infants in solitary sleep. One-month co-parenting quality was associated with predictable shifts in sleep arrangements from 1 to 6 months, but 1-month sleep arrangements did not predict changes in personal or co-parenting quality. Findings emphasize the need for greater attention to marital and emotional health in influencing family-level decisions about infant sleep arrangements.

Infant sleeping arrangements and cultural values among contemporary Japanese mothers.

We examined infant sleeping arrangements and cultural values of Japanese mothers in 2008 and 2009. Based on Greenfield's theory of social change and human development, we predicted that social change in Japan over the last decades (higher economic and education level, urbanization, complex technology, more women in the work force) would lead to a decline in mother-infant co-sleeping, compared with published findings concerning Japanese sleeping arrangements in the 1960s and 1980s. We also predicted that the practice of having babies sleep in their own beds and/or own rooms would be supported by ethnotheories stressing infant independence and other values adaptive in an urban, technologically sophisticated, relatively wealthy, and highly educated populace. Fifty-one Japanese mothers' comments posted on Internet parenting forums were analyzed. Contrary to our hypothesis, co-sleeping was as frequent among Japanese mothers in 2008-2009 as it had been in the 1960s and 1980s. However, analysis of the values of co-sleeping mothers revealed frequent discrepancies between values and practices. In contrast, the minority of mothers whose babies slept alone in a separate room all expressed consonant values. Our qualitative analysis indicates that it is not always easy for Japanese mothers to construct values for child rearing and gender roles that integrate traditional infant care practices with current sociodemographic conditions.

Opaliferin, a new polyketide from cultures of entomopathogenic fungus Cordyceps sp. NBRC 106954.

Opaliferin, a polyketide with a unique partial structure in which a cyclopentanone and tetrahydrofuran were connected with an external double bond, was isolated from the insect pathogenic fungus Cordyceps sp. NBRC 106954. The structure and relative configuration of opaliferin were determined by spectroscopic analysis and X-ray crystallography. The absolute configuration was established by anomalous dispersion effects in X-ray diffraction measurements on the crystal of di(p-bromobenzoyl) ester of opaliferin. A plausible biosynthetic pathway for opaliferin is proposed.

Maternal emotional availability at bedtime and infant cortisol at 1 and 3 months.

BACKGROUND: Previous work has shown that early experience influences infant cortisol secretion. Few studies, however, have examined associations between parenting quality and cortisol levels and patterning in very young infants. AIMS: This study examined linkages between maternal emotional availability (EA) during a routine caregiving task, bedtime, and infant cortisol in the first 3 months of life. Concurrent and longitudinal associations between maternal EA and infant cortisol were examined. STUDY DESIGN: Families were visited when their infants were 1 and 3 months old. Video equipment was set up in order to record the infant's bedtime routine. Parents were provided with materials with which to take saliva samples from their infants at late afternoon, bedtime, and the following morning. SUBJECTS: At 1 month, participants were 96 mothers and infants living in a rural U.S. state. Data were available for 88 mothers and infants at 3 months. OUTCOME MEASURES: Maternal EA was scored from videotapes of bedtime at each age point. Infant cortisol was assessed from the saliva samples taken by parents. RESULTS: Regression analyses indicated that at 1 and 3 months of age, infants of more emotionally available mothers showed lower levels of cortisol secretion across the night than infants of less emotionally available mothers. Additionally, multilevel model analyses indicated that infants of more emotionally available mothers showed greater evidence of a decline in their cortisol levels across the evening, followed by an increase across the nighttime into the morning in their cortisol at 3 months. CONCLUSIONS: Findings suggest that maternal care in the context of a routine caregiving task is associated with lower stress reactivity and with earlier circadian patterning in very young infants.

In vitro antitrypanosomal activity of the cyclodepsipeptides, cardinalisamides A-C, from the insect pathogenic fungus Cordyceps cardinalis NBRC 103832.

During the search for new antitrypanosomal drug leads, three new antitrypanosomal compounds, cardinalisamides A-C (1-3), were isolated from cultures of the insect pathogenic fungus Cordyceps cardinalis NBRC 103832. Their structures were elucidated using MS analyses and extensive 2D-heteronuclear NMR. The absolute configurations of 1-3 were addressed by chemical degradation and Marfey's analysis. 1-3 showed in vitro antitrypanosomal activity against Trypanosoma brucei brucei with IC50 values of 8.56, 8.65 and 8.63 µg ml(-1), respectively.

[Unruptured aneurysm arising from fenestration of the horizontal (A1) segment in the anterior cerebral artery: a case report and review of the literature].

Cerebral aneurysms arising from fenestration of the horizontal (A(1)) segment in the anterior cerebral artery (ACA) are very rare. In this paper, we report our case, discuss radiological features, and review previous cases. A 70-year-old male was referred to our hospital presenting with memory disturbance. His unruptured cerebral aneurysm in the A(1) segment was incidentally found by magnetic resonance angiography (MRA). Three dimensional computed tomographic angiography (3D-CTA) demonstrated this aneurysm arising from fenestration of the A(1) segment. Surgical neck clipping was performed via the pterional approach, while sacrificing one pair of the A(1) segment. The patient's post operative course was uneventful. Only 14 cases with an aneurysm arising from fenestration of the A(1) segment have been reported previously. In the present case, 3D-CTA was very useful for finding out where the aneurysm arose from, and we also had to be careful about perforating arteries from the A(1) segment during the surgery.

Pleomorphic primitive neuroectodermal tumor with glial and neuronal differentiation: clinical, pathological, cultural, and chromosomal analysis of a case.

This paper examines a case of pleomorphic primitive neuroectodermal tumor (PNET) with glial and neuronal differentiation in a 7-year-old girl who was clinicopathologically reported with immunohistochemical and chromosomal analysis. Clinically, a highly aggressive behavior leading to early recurrence with cerebrospinal fluid seedings was characteristic despite total removal and chemoradiation therapy. Pathologically, severe pleomorphism was noted and large ganglioid cells were predominant. Immunohistochemically, the expression of low-molecular neurofilament was recognized in the surgical specimens and increased in the recurrence. Coexpression of vimentin and neurofilament/GFAP was recognized in the culture. Chromosomal analysis showed near-diploidy, but different karyotype from that PNETs previously reported. These findings suggested that PNETs with pleomorphism and differentiation into both glial and neuronal lineages may show aggressiveness and require more aggressive therapy.