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J Nat Med ; 78(3): 709-721, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38575838

ABSTRACT

Methanol extract of the Cnidium officinale Makino rhizome, which is used as a crude drug Cnidium Rhizome (Cnidii Rhizoma; "Senkyu" in Japanese) and is listed in the Japanese Pharmacopoeia XVIII, showed intracellular triglyceride metabolism-promoting activity in high glucose-pretreated HepG2 cells. Thirty-five constituents, including two new alkylphthalide glycosides, senkyunosides A (1) and B (2), and a neolignan with a new stereoisomeric structure (3), were isolated in the extract. Their stereostructures were elucidated based on chemical and spectroscopic evidence. Among the isolates, several alkylphthalides, (Z)-3-butylidene-7-methoxyphthalide (9) and senkyunolides G (10), H (14), and I (15), and a polyacetylene falcarindiol (26), were found to show significant activity without any cytotoxicity at 10 µM.


Subject(s)
Benzofurans , Cnidium , Rhizome , Triglycerides , Humans , Rhizome/chemistry , Hep G2 Cells , Cnidium/chemistry , Triglycerides/metabolism , Benzofurans/pharmacology , Benzofurans/chemistry , Benzofurans/isolation & purification , Molecular Structure , Plant Extracts/pharmacology , Plant Extracts/chemistry , Glycosides/pharmacology , Glycosides/chemistry , Glycosides/isolation & purification
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