Quantum-enhanced hybrid feature engineering in thoracic CT image analysis for state-of-the-art nodule classification: an advanced lung cancer assessment.

The intricate nature of lung cancer treatment poses considerable challenges upon diagnosis. Early detection plays a pivotal role in mitigating its escalating global mortality rates. Consequently, there are pressing demands for robust and dependable early detection and diagnostic systems. However, the technological limitations and complexity of the disease make it challenging to implement an efficient lung cancer screening system. AI-based CT image analysis techniques are showing significant contributions to the development of computer-assisted detection (CAD) systems for lung cancer screening. Various existing research groups are working on implementing CT image analysis systems for assessing and classifying lung cancer. However, the complexity of different structures inside the CT image is high and comprehension of significant information inherited by them is more complex even after applying advanced feature extraction and feature selection techniques. Traditional and classical feature selection techniques may struggle to capture complex interdependencies between features. They may get stuck in local optima and sometimes require additional exploration strategies. Traditional techniques may also struggle with combinatorial optimization problems when applied to a prominent feature space. This paper proposed a methodology to overcome the existing challenges by applying feature extraction using Vision Transformer (FexViT) and Feature selection using the Quantum Computing based Quadratic unconstrained binary optimization (QC-FSelQUBO) technique. This algorithm shows better performance when compared with other existing techniques. The proposed methodology showed better performance as compared to other existing techniques when evaluated by applying necessary output measures, such as accuracy, Area under roc (receiver operating characteristics) curve, precision, sensitivity, and specificity, obtained as 94.28%, 99.10%, 96.17%, 90.16% and 97.46%. The further advancement of CAD systems is essential to meet the demand for more reliable detection and diagnosis of cancer, which can be addressed by leading the proposed quantum computation and growing AI-based technology ahead.

Hyperparameter optimization and development of an advanced CNN-based technique for lung nodule assessment.

Objective. This paper aims to propose an advanced methodology for assessing lung nodules using automated techniques with computed tomography (CT) images to detect lung cancer at an early stage.Approach. The proposed methodology utilizes a fixed-size 3 × 3 kernel in a convolution neural network (CNN) for relevant feature extraction. The network architecture comprises 13 layers, including six convolution layers for deep local and global feature extraction. The nodule detection architecture is enhanced by incorporating a transfer learning-based EfficientNetV_2 network (TLEV2N) to improve training performance. The classification of nodules is achieved by integrating the EfficientNet_V2 architecture of CNN for more accurate benign and malignant classification. The network architecture is fine-tuned to extract relevant features using a deep network while maintaining performance through suitable hyperparameters.Main results. The proposed method significantly reduces the false-negative rate, with the network achieving an accuracy of 97.56% and a specificity of 98.4%. Using the 3 × 3 kernel provides valuable insights into minute pixel variation and enables the extraction of information at a broader morphological level. The continuous responsiveness of the network to fine-tune initial values allows for further optimization possibilities, leading to the design of a standardized system capable of assessing diversified thoracic CT datasets.Significance. This paper highlights the potential of non-invasive techniques for the early detection of lung cancer through the analysis of low-dose CT images. The proposed methodology offers improved accuracy in detecting lung nodules and has the potential to enhance the overall performance of early lung cancer detection. By reconfiguring the proposed method, further advancements can be made to optimize outcomes and contribute to developing a standardized system for assessing diverse thoracic CT datasets.