ABSTRACT
JGP study (Rayaprolu et al. https://doi.org/10.1085/jgp.202313467) shows that hydrophobic residues in the S1 transmembrane domain modulate the voltage sensor movements and enzymatic activity of voltage-sensing phosphatase.
Subject(s)
Hydrophobic and Hydrophilic Interactions , Animals , HumansABSTRACT
JGP study (Duno-Miranda et al. https://doi.org/10.1085/jgp.202313522) shows that a mutation linked to dilated cardiomyopathy stabilizes ß-cardiac myosin in its autoinhibited, super-relaxed state.
Subject(s)
Mutation , Humans , Cardiomyopathy, Dilated/genetics , Cardiomyopathy, Dilated/metabolism , AnimalsABSTRACT
JGP study (Asghari et al. 2024. J. Gen. Physiol.https://doi.org/10.1085/jgp.202213108) indicates that ß-adrenergic signaling enlarges dyads and reorganizes RyR2 tetramers in cardiomyocytes.
Subject(s)
Myocytes, Cardiac , Ryanodine Receptor Calcium Release Channel , Phosphorylation , Ryanodine Receptor Calcium Release Channel/chemistry , Signal TransductionABSTRACT
JGP study (Lucero et al. http://www.doi.org/10.1085/jgp.202313464) shows that members of the SMRGdx subtype can export the degradation products of metformin, helping bacteria adapt to high environmental levels of the commonly prescribed diabetes medication.
Subject(s)
Membrane Transport Proteins , MetforminABSTRACT
JGP study (Bernas et al. 2024. J. Gen. Physiol.https://doi.org/10.1085/jgp.202313436) suggests that, by altering microtubule dynamics, persistent PKA activation promotes the delivery of Nav1.5 channels to intercalated discs.
ABSTRACT
JGP study (this issue, Caremani et al. https://doi.org/10.1085/jgp.202313393) reveals that the calcium sensitivity of thick filament structure in skeletal muscle is greater than that of force, offering new insights into the mechanisms of thick filament activation.
Subject(s)
Calcium , Muscle, Skeletal , SarcomeresABSTRACT
JGP study (In this issue, Osten et al. https://doi.org/10.1085/jgp.202313377) suggests that, by altering mechanosensitive signaling pathways, replating stem cell-derived cardiomyocytes changes myosin expression and contractile function.
Subject(s)
Muscle Contraction , Myosins , Signal TransductionABSTRACT
JGP study (Komondor et al. 2023. J. Gen. Physiol. https://doi.org/10.1085/jgp.202213258) reveals that conventional PLC activation pathways are not required for the fertilization-induced depolarization of Xenopus eggs that prevents the entry of additional sperm.
Subject(s)
Fertilization , Ovum , Semen , Xenopus , Animals , Xenopus/physiology , Ovum/physiologyABSTRACT
JGP study (Hermanstyne et al. 2023. J. Gen. Physiol.https://doi.org/10.1085/jgp.202213310) shows that Kv12-encoded K+ currents reduce the repetitive firing rates of SCN neurons at night, thereby regulating daily oscillations in the master circadian pacemaker.
Subject(s)
Circadian Rhythm , Suprachiasmatic Nucleus , Circadian Rhythm/physiology , Suprachiasmatic Nucleus/physiology , Neurons/physiologyABSTRACT
JGP study (Kopec et al. 2023. J. Gen. Physiol.https://doi.org/10.1085/jgp.202213166) reveals how interactions with pore-helix residues control filter inactivation in the prokaryotic potassium channel MthK.
ABSTRACT
JGP study (Lehman and Rynkiewicz. 2023. J. Gen. Physiol.https://doi.org/10.1085/jgp.202313387) suggests that tropomyosin regulates the crossbridge cycle in muscle by pivoting around relatively fixed points on actin thin filaments.
Subject(s)
Actins , Tropomyosin , Actin Cytoskeleton , Muscles , CalciumABSTRACT
JGP study (Gada et al. 2023. J. Gen. Physiol. https://doi.org/10.1085/jgp.202213255) reveals that the membrane lipid PI(4,5)P2 alters the activity of NaV1.4 channels by modulating their gating behavior.
Subject(s)
Voltage-Gated Sodium Channels , Membrane LipidsABSTRACT
JGP study (Takeuchi and Kurahashi. 2023. J. Gen. Physiol.https://doi.org/10.1085/jgp.202213165) reveals that segregation of signals within sensory cilia allows Ca2+ to play opposing roles in olfactory signal transduction.
Subject(s)
Olfactory Receptor Neurons , Olfactory Receptor Neurons/physiology , Cilia , Calcium , Signal Transduction/physiology , Smell/physiologyABSTRACT
A new gating current recording protocol shows that gating hysteresis is a kinetic phenomenon, rather than an inherent thermodynamic property of Shaker potassium channels.
Subject(s)
Ion Channel Gating , Potassium Channels , Potassium Channels/metabolism , Shaker Superfamily of Potassium Channels , Kinetics , Thermodynamics , Oocytes/metabolismABSTRACT
JGP study reveals how the neurotransmitter PACAP induces a secretory response in chromaffin cells that differs from the one induced by acetylcholine.
Subject(s)
Chromaffin Cells , Chromaffin Cells/metabolism , Pituitary Adenylate Cyclase-Activating Polypeptide/metabolism , Exocytosis/physiologyABSTRACT
Researchers develop experimental platform that could be used to evaluate mutations and screen drugs for skeletal muscle diseases.
Subject(s)
Calcium , Muscle, Skeletal , Muscle, Skeletal/physiology , Mutation , Drug DiscoveryABSTRACT
JGP study suggests that Kv1 channels share a common mechanism of slow inactivation, but that some family members are less prone to inactivate than others.
ABSTRACT
JGP study reveals that adult zebrafish skeletal muscle fibers display the fastest kinetics of excitation-contraction coupling ever measured in vertebrate locomotor muscles.
Subject(s)
Muscle Fibers, Skeletal , Zebrafish , Animals , Excitation Contraction Coupling , Muscle Fibers, Skeletal/physiologyABSTRACT
JGP study identifies a novel peptide in scorpion venom that inhibits KV1.2 and KV1.3 channels and could form the basis for new treatments for autoimmune diseases.
Subject(s)
Scorpion Venoms , Animals , Kv1.3 Potassium Channel , Peptides , Potassium Channel Blockers/pharmacology , Scorpion Venoms/pharmacology , Scorpions , T-LymphocytesABSTRACT
JGP study uses both natural and unnatural amino acid substitutions to examine how a key tyrosine residue controls the selectivity of the Na+/K+ pump.
