ABSTRACT
BACKGROUND: Corneal fluorescein staining is a key biomarker in evaluating dry eye disease. However, subjective scales of corneal fluorescein staining are lacking in consistency and increase the difficulties of an accurate diagnosis for clinicians. This study aimed to propose an automatic machine learning-based method for corneal fluorescein staining evaluation by utilizing prior information about the spatial connection and distribution of the staining region. METHODS: We proposed an end-to-end automatic machine learning-based classification model that consists of staining region identification, feature signature construction, and machine learning-based classification, which fully scrutinizes the multiscale topological features together with conventional texture and morphological features. The proposed model was evaluated using retrospective data from Beijing Tongren Hospital. Two masked ophthalmologists scored images independently using the Sjögren's International Collaborative Clinical Alliance Ocular Staining Score scale. RESULTS: A total of 382 images were enrolled in the study. A signature with six topological features, two textural features, and two morphological features was constructed after feature extraction and selection. Support vector machines showed the best classification performance (accuracy: 82.67%, area under the curve: 96.59%) with the designed signature. Meanwhile, topological features contributed more to the classification, compared with other features. According to the distribution and correlation with features and scores, topological features performed better than others. CONCLUSIONS: An automatic machine learning-based method was advanced for corneal fluorescein staining evaluation. The topological features in presenting the spatial connectivity and distribution of staining regions are essential for an efficient corneal fluorescein staining evaluation. This result implies the clinical application of topological features in dry-eye diagnosis and therapeutic effect evaluation.
ABSTRACT
A pedestrian was estimated to be killed every 85 min and injured every 7 min on US roads in 2019. Targeted safety treatments are particularly required at urban intersections where pedestrians regularly conflict with turning vehicles. Leading Pedestrian Intervals (LPIs) are an innovative, low-cost treatment where the pedestrian and vehicle usage of the potential conflict area (a crosswalk) is staggered in time to give the pedestrians a head start of a few seconds and reduce the "element of surprise" for right-turning vehicles. The effectiveness of LPI treatment on pedestrian safety is mixed, and most importantly, its effect on vehicle-vehicle conflicts is unknown. This study investigates the before-after effects of LPI treatments on vehicle-pedestrian and vehicle-vehicle crash risk by applying traffic conflict techniques. In particular, this study has developed a quantile regression technique within the extreme value model to estimate and compare crash risks before and after the installation of the LPI treatment. The before-after traffic movement video data (504 h in total) were collected from three signalized intersections in the City of Bellevue, Washington. The recorded movements were analyzed using Microsoft's proprietary computer vision platform, Edge Video Service, and Advanced Mobility Analytics Group's cloud-based SMART SafetyTM platform to automatedly extract traffic conflicts by analyzing road user trajectories. The treatment effect was measured using a Bayesian hierarchical extreme value model with the peak-over threshold approach. For the extreme value model, a Bayesian quantile regression analysis was conducted to estimate the conflict thresholds corresponding to a high (95th) quantile. Odds ratios were estimated for both conflict types using untreated crossing as a control group. Results indicate that the LPI treatment reduces the crash risk of pedestrians as measured by the reduction in extreme vehicle-pedestrian conflicts by about 42%. The LPI treatment has also been found not to negatively affect rear-end conflicts along the approaches leading to the LPI-treated pedestrian crossing at the signalized intersections. The findings of this study further emphasize the effectiveness of video analytics in proactive safety evaluations of engineering treatments.