1.
Chem Biodivers
; 19(1): e202100584, 2022 Jan.
Article
in English
| MEDLINE
| ID: mdl-34752012
ABSTRACT
Synthesis of novel C3-substituted 5,6-dihydropyrrolo[2,1-a]isoquinolines via a three-component domino reaction of 1-aroyl-3,4-dihydroisoquinolines, terminal alkynes and CH-acids under microwave irradiation in dry acetonitrile is described. The method developed enables the obtainment of highly functionalized compounds with pharmacophore groups, which are potentially biologically active.