ABSTRACT
There is some evidence in the literature of the photocyclization reaction of Tagitinin C (1) to Tagitinin F (2). Compound 2 has high pharmacological potential, but it is not easy to obtain, while compound 1 is easily obtained from a widespread plant, Tithonia diversifolia. Among different reaction conditions monitored, one was found that allowed the cyclization of 1 into 2 in <15 min in a photo-dependent reaction. Scaling-up the photocyclization of the pure compound 1 into 2 demonstrated 100% yield, and the isolation of 2 from a UV-irradiated extract was eight-fold higher than the quantity isolated from the non-UV-irradiated extract. We were also able to better understand the process of photoconversion and determine methods to isolate and quantify these compounds, which are known for their important antitumoral activities among other important pharmacological properties.
Subject(s)
Photochemical Processes , Plant Extracts/chemistry , Sesquiterpenes/isolation & purification , Chromatography, High Pressure Liquid , Cyclization , Magnetic Resonance Spectroscopy , Mass Spectrometry/methods , Reproducibility of Results , Sesquiterpenes/chemistry , Spectrophotometry, Ultraviolet , Ultraviolet RaysABSTRACT
O objetivo deste estudo foi identificar como o Grupo Operativo tem sido utilizado na área de saúde e quais as evidências de seu uso na literatura científica. Foi realizada revisão integrativa, nas bases : Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Medical Literature Analysis and Retrietal Systen On-Line (MEDLINE) e National Library of Medicine na base PUBMED. Selecionaram-se artigos publicados de 2002 a julho de 2014 que abordassem o Grupo Operativo proposto por Pichon-Rivière. Foram encontrados 23 artigos discutidos nas categorias : Grupo Operativo na Atenção à Saúde das Pessoas; Grupo Operativo no Processo Ensino-Aprendizagem do Profissional; Uso do Grupo Operativo na Gestão de Serviços em Saúde; Grupo Operativo na Pesquisa em Saúde. O Grupo Operativo é adotado na atenção à saúde em doenças crônicas, pesquisa, gestão e formação de trabalhadores de saúde. Conclui-se que essa ferramenta é relevante para o cuidado e que são necessárias pesquisas com outros delineamentos metodológicos.
This study aimed to identify how the Operative Group has been used in the area of health, and what the evidence is for its use in the scientific literature. An integrative review was undertaken, in the following databases: Latin American and Caribbean Center on Health Science Information (LILACS), Medical Literature Analysis and Retrieval System On-Line (MEDLINE) and National Library of Medicine in the PUBMED database. Articles published between 2002 and July 2014, which addressed the Operative Group, as proposed by Pichon-Rivière, were selected. A total of 23 articles was found, discussed in the following categories: the Operative Group in Peoples' Health Care; the Operative Group in the Professional's Teaching-Learning Process; the Use of the Operative Group in the Management of Health Services; and, the Operative Group in Health Research. The Operative Group has been adopted in health care for chronic illnesses, research, management, and training of health workers. It is concluded that this tool is relevant for the care and that studies with other methodological designs are necessary.
El objetivo de este estudio fue identificar cómo el Grupo Operativo viene siendo utilizado en el área de salud y cuales las evidencias de su uso en la literatura científica. Fue realizada revisión integrativa, en las bases: Literatura Latinoamericana y de Caribe en Ciencias de la Salud (LILACS), Medical Literature Analysis and Retrietal Systen On-Line (MEDLINE) y National Library of Medicine en la base PUBMED. Fueron seleccionados artículos publicados de 2002 a julio de 2014 que abordasen el Grupo Operativo propuesto por Pichon-Rivière. Fueron hallados 23 artículos discutidos en las categorías: Grupo Operativo en la Atención a la Salud de las Personas; Grupo Operativo en el Proceso Enseñanza-Aprendizaje del Profesional; Uso del Grupo Operativo en la Gestión de Servicios en Salud; Grupo Operativo en la Investigación en Salud. El Grupo Operativo es adoptado en la atención a la salud en enfermedades crónicas, investigación, gestión y formación de trabajadores de salud. Se concluyse que esa herramienta es relevante para el cuidado y que son necesarias investigaciones con otros métodos.