Exploring the Effect of Acute and Regular Physical Exercise on Circulating Brain-Derived Neurotrophic Factor Levels in Individuals with Obesity: A Comprehensive Systematic Review and Meta-Analysis.

Obesity is a major global health concern linked to cognitive impairment and neurological disorders. Circulating brain-derived neurotrophic factor (BDNF), a protein crucial for neuronal growth and survival, plays a vital role in brain function and plasticity. Notably, obese individuals tend to exhibit lower BDNF levels, potentially contributing to cognitive decline. Physical exercise offers health benefits, including improved circulating BDNF levels and cognitive function, but the specific impacts of acute versus regular exercise on circulating BDNF levels in obesity are unclear. Understanding this can guide interventions to enhance brain health and counter potential cognitive decline in obese individuals. Therefore, this study aimed to explore the impact of acute and regular physical exercise on circulating BDNF in individuals with obesity. The target population comprised individuals classified as overweight or obese, encompassing both acute and chronic protocols involving all training methods. A comprehensive search was conducted across computerized databases, including PubMed, Academic Search Complete, and Web of Science, in August 2022, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Initially, 98 studies were identified, from which 16 studies, comprising 23 trials, met the selection criteria. Substantial heterogeneity was observed for both acute (I2 = 80.4%) and long-term effects (I2 = 88.7%), but low risk of bias for the included studies. A single session of exercise increased circulating BDNF levels among obese patients compared to the control group (ES = 1.25, 95% CI = 0.19 to 2.30, p = 0.021). However, with extended periods of physical exercise, there was no significant increase in circulating BDNF levels when compared to the control group (ES = 0.49, 95% CI = -0.08 to 1.06, p = 0.089). These findings highlight the need to consider exercise duration and type when studying neurobiological responses in obesity and exercise research. The study's results have implications for exercise prescription in obesity management and highlight the need for tailored interventions to optimize neurotrophic responses. Future research should focus on elucidating the adaptive mechanisms and exploring novel strategies to enhance BDNF modulation through exercise in this population. However, further research is needed considering limitations such as the potential age-related confounding effects due to diverse participant ages, lack of sex-specific analyses, and insufficient exploration of how specific exercise parameters (e.g., duration, intensity, type) impact circulating BDNF.

Testing variations between starters and substitute players in terms of total distance, high-speed running, and sprinting distance: a descriptive study on professional male soccer players.

The purpose of this study was three-fold: (i) to compare total distance, high-speed running (HSR) distance, and sprint distance covered per 5-minute epoch by players acting as both starters and substitutes; (ii) to compare the locomotor demands between the moments the players entered the match (45-60, 60-75 and 75-90 minutes); and (iii) to compare the locomotor demands of the players between the variations of the within- and between-playing positions. Twenty-one male professional soccer players competing in the Professional Premier League of one of the European countries were observed over sixteen official matches. The players were monitored during all matches using a Global Navigation Satellite System. The measures collected were total distance (TD; m), distance in HSR, sprint distance, HSR, and sprint counts. Considering the comparisons between the splits over the second half of match play, a significant difference between the starters and the substitutes was observed only for sprint distance in the 90-95 minute split (Z = -2.023; p = 0.043). Moreover, no substantial differences were found between the moment the substitute player entered the match regarding total distance (H = 2.650; p = 0.266), HSR distance (H = 1.738; p = 0.419), and sprint distance (H = 0.048; p = 0.976). However, the comparison of between-playing positions revealed considerable differences in total distance (H = 29.246; p < 0.001), and HSR distance (H = 12.153; p = 0.002) covered by the players acting as starters. In contrast, for substitute players, such differences were reported in HSR distance (H = 27.892; p < 0.001) and sprint distance (H = 15.879; p < 0.001). In conclusion, this study suggests that acting as a starter or a substitute does not significantly affect the intensity of effort except during the last periods of match play. However, the contextual factor of performing in a specific playing position plays a significant role both for starters and substitutes.

What We Do Not Know About Stretching in Healthy Athletes: A Scoping Review with Evidence Gap Map from 300 Trials.

BACKGROUND: Stretching has garnered significant attention in sports sciences, resulting in numerous studies. However, there is no comprehensive overview on investigation of stretching in healthy athletes. OBJECTIVES: To perform a systematic scoping review with an evidence gap map of stretching studies in healthy athletes, identify current gaps in the literature, and provide stakeholders with priorities for future research. METHODS: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 and PRISMA-ScR guidelines were followed. We included studies comprising healthy athletes exposed to acute and/or chronic stretching interventions. Six databases were searched (CINAHL, EMBASE, PubMed, Scopus, SPORTDiscus, and Web of Science) until 1 January 2023. The relevant data were narratively synthesized; quantitative data summaries were provided for key data items. An evidence gap map was developed to offer an overview of the existing research and relevant gaps. RESULTS: Of ~ 220,000 screened records, we included 300 trials involving 7080 athletes [mostly males (~ 65% versus ~ 20% female, and ~ 15% unreported) under 36 years of age; tiers 2 and 3 of the Participant Classification Framework] across 43 sports. Sports requiring extreme range of motion (e.g., gymnastics) were underrepresented. Most trials assessed the acute effects of stretching, with chronic effects being scrutinized in less than 20% of trials. Chronic interventions averaged 7.4 ± 5.1 weeks and never exceeded 6 months. Most trials (~ 85%) implemented stretching within the warm-up, with other application timings (e.g., post-exercise) being under-researched. Most trials examined static active stretching (62.3%), followed by dynamic stretching (38.3%) and proprioceptive neuromuscular facilitation (PNF) stretching (12.0%), with scarce research on alternative methods (e.g., ballistic stretching). Comparators were mostly limited to passive controls, with ~ 25% of trials including active controls (e.g., strength training). The lower limbs were primarily targeted by interventions (~ 75%). Reporting of dose was heterogeneous in style (e.g., 10 repetitions versus 10 s for dynamic stretching) and completeness of information (i.e., with disparities in the comprehensiveness of the provided information). Most trials (~ 90%) reported performance-related outcomes (mainly strength/power and range of motion); sport-specific outcomes were collected in less than 15% of trials. Biomechanical, physiological, and neural/psychological outcomes were assessed sparsely and heterogeneously; only five trials investigated injury-related outcomes. CONCLUSIONS: There is room for improvement, with many areas of research on stretching being underexplored and others currently too heterogeneous for reliable comparisons between studies. There is limited representation of elite-level athletes (~ 5% tier 4 and no tier 5) and underpowered sample sizes (≤ 20 participants). Research was biased toward adult male athletes of sports not requiring extreme ranges of motion, and mostly assessed the acute effects of static active stretching and dynamic stretching during the warm-up. Dose-response relationships remain largely underexplored. Outcomes were mostly limited to general performance testing. Injury prevention and other effects of stretching remain poorly investigated. These relevant research gaps should be prioritized by funding policies. REGISTRATION: OSF project ( https://osf.io/6auyj/ ) and registration ( https://osf.io/gu8ya ).

Effects of 8 weeks pre-season training on physical fitness, heart rate variability and cognition in women soccer players.

The aim of this study was to explore the variations (pre-post) of (i) Anthropometric measures: weight, body mass index, lean and muscle mass, (ii) Physical fitness: countermovement jump (CMJ) and VO2max, (iii) heart rate variability (HRV) (recumbent and sitting): mean RR, RMSSD, NN50 and NN50 %, (iv) Psychomotor Vigilance Task, and v) SART: ACC Go, ACC NoGo and reaction times in semi-professional women soccer players from the second division of the Spanish League. The analysis indicated that lean mass improved after the observation period (p = .05, d = -0.38), while no other significant changes in anthropometric measures were observed. Additionally, CMJ and aerobic power were also improved (p<.01, d>0.50). The RMSSD [recumbent (d = -0.73) and sitting (d = -0.52)] and NN50 [recumbent (d = -0.69) and sitting (d = -0.70)] increased after the period of observation (p < .05). Reaction time also significantly improved after the period of observation [PVT (d = 0.42) and SART (d = -0.89)]. Correlations performed between measures revealed that smaller body mass and body mass index were largely associated with greater NN50 (r < 0.83, p = .001). Additionally, greater CMJ and aerobic fitness were associated with greater HRV [recumbent (r = -51, p = .001) and sitting (r = -0.60, p = .01). The main findings of this study were that there was no relationship between cognitive performance and physical fitness, but HRV was related to body composition and physical fitness during the pre-season in women soccer players.

Incidence of myocardial injury in patients submitted to carotid endarterectomy.

Myocardial injury following noncardiac surgery (MINS) is associated with higher mortality and major adverse cardiovascular event rates in the short- and long-term in patients undergoing carotid endarterectomy (CEA). However, its incidence is still unclear in this subset of patients. Therefore, this systematic review with meta-analysis aims to determine the incidence of MINS in patients undergoing CEA. Three electronic databases MEDLINE, Scopus, and Web of Science were used to search for studies assessing the occurrence of MINS in the postoperative setting of patients undergoing CEA. The incidence of MINS was pooled by random-effects meta-analysis, with sources of heterogeneity being explored by meta-regression and subgroup analysis (general anesthesia vs. regional anesthesia). Assessment of studies' quality was performed using National Heart, Lung, and Blood Institute Study Quality Assessment Tool, and Risk of Bias 2 tools. Twenty studies were included, with a total of 117,933 participants. Four of them were RCTs, while the remaining were cohort studies. All observational cohorts had an overall high risk of bias, except for Pereira Macedo et al. Three of them had repeated population, thus only data from the most recent one was considered. On the other hand, all RCT had an overall low risk of bias. In patients under regional anesthesia, the incidence of MINS in primary studies ranged between 2% and 15.3%, compared to 0-42.5% for general anesthesia. The meta-analytical incidence of MINS after CEA was of 6.3% [95% CI 2.0-10.6%], but severe heterogeneity was observed (I2=99.1%). MINS appears to be relatively common among patients undergoing CEA. The observed severe heterogeneity points to the need for further larger studies adopting consistent definitions of MINS and equivalent cut-off values.

Azorean Black Tea (Camellia sinensis) Antidermatophytic and Fungicidal Properties.

The treatment of dermatophytoses, the most common human fungal infections, requires new alternatives. The aim of this study was to determine the antidermatophytic activity of the aqueous Azorean Black Tea extract (ABT), together with an approach to the mechanisms of action. The phytochemical analysis of ABT extract was performed by HPLC. The dermatophytes susceptibility was assessed using a broth microdilution assay; potential synergies with terbinafine and griseofulvin were evaluated by the checkerboard assay. The mechanism of action was appraised by the quantification of the fungal cell wall chitin and ß-1,3-glucan, and by membrane ergosterol. The presence of ultrastructural modifications was studied by Transmission Electron Microscopy (TEM). The ABT extract contained organic and phenolic acids, flavonoids, theaflavins and alkaloids. It showed an antidermatophytic effect, with MIC values of 250 µg/mL for Trichophyton mentagrophytes, 125 µg/mL for Trichophyton rubrum and 500 µg/mL for Microsporum canis; at these concentrations, the extract was fungicidal. An additive effect of ABT in association to terbinafine on these three dermatophytes was observed. The ABT extract caused a significant reduction in ß-1,3-glucan content, indicating the synthesis of this cell wall component as a possible target. The present study identifies the antidermatophytic activity of the ABT and highlights its potential to improve the effectiveness of conventional topical treatment currently used for the management of skin or mucosal fungal infections.

Validity and reliability of Polar M400 GPS watches for measuring distances covered by team sports players.

Monitoring locomotor demands in team sports becomes popular in professional and recreational daily activities. Precise measurements are main of importance in training routine. The aim of this study is three-fold: (i) analyze the validity of Polar M400 Global Positioning System (GPS) watches for measuring distances covered in team sports simulation cycle; (ii) testing inter-unit reliability of two devices attached during testing; and (iii) testing inter-session reliability for the same simulation cycle. Methods: Twenty-one team athletes (age: 24.5 ± 5.2 years; body mass: 71.8 ± 5.7 kg; height: 176.5 ± 4.3 cm) were tested in the team sport simulation cycle (TSSC). Two Polar M400 sport watches were used by each player on their wrists at the same time. The data obtained from Polar M400 were compared to the reference fixed distance of the TSSC to determine the watch validity. Inter-session reliability was also tested using the two watches in two different sessions. Results: No significant differences between the reference value and the watches (F = 1.086; p = 0.368; ηp2 ≤0.042) were found. The %CV (0.03-0.05%) and SEM (0.05-0.09) values found for all considered groups confirmed good levels of reliability of the Polar M400 to measure total distance. Conclusions: The Polar M400 is a valid and reliable watch for measuring the distances covered by team sport athletes. Both coaches and athletes can monitor the distances covered with accuracy and precision, through the use of the Polar M400 sport watch.

Variability of peak speed and sprinting actions during the same small-sided games: within- and between-player variations inspected over four consecutive weeks.

This study aimed to analyze within- and between-player variations of peak speed and sprinting actions occurring in small-sided games (SSGs: 1 v 1 and 5 v 5). The study followed a cohort study design. Twenty male youth soccer players (age: 17 years old) from the same team were observed over four consecutive weeks. Each week, the players participated in two sessions (day one and day two) during which SSGs were applied. The 1 vs. 1 format was employed with four repetitions of thirty seconds interspaced with two-minute rest intervals, while the 5 vs. 5 format with four repetitions of four minutes and two-minute rest intervals between them. The players were monitored during all training sessions with the Polar Team Pro. The peak speed attained in each game, and the number of sprints were extracted as the primary outcomes. The between-player variability revealed a lower coefficient of variations for peak speed in the 1 vs. 1 (13.9%) and 5 vs. 5 (10.9%) formats than for sprints (1 v 1: 64.7%; 5 v 5: 65.5%). Considering the within-player variability, it was observed that sprints were more variable (1 vs. 1: 62.1%; 5 v 5: 65.7%) than peak speed (1 vs. 1: 16.4%; 5 v 5: 14.0%). The between-session analysis revealed that during week 1 (day 1), peak speed was significantly higher than during week 3 (day 1) in the 1 vs. 1 format (+3.0 km/h; p = 0.031; d = 1.296). Moreover, peak speed during week 3 (day 2) was considerably lower than during week 1 (-5.9 km/h; p < 0.001; d = 1.686) and week 2 (-5.0 km/h; p = 0.001; d = 1.639). The between-session analysis showed no significant differences in the sprint between the sessions on day 1 (p > 0.05). However, on day two, the sprint was substantially higher during week one than during week four in the 5 vs. 5 format (+5.40 n; p = 0.002; d = 2.571). In conclusion, this study revealed that peak speed presents lower within- and between-player variability than the number of sprints. Considering these two measures, there are no considerable variations between the weeks. Coaches should consider identifying strategies to stabilize the stimulus regarding the number of sprints if this represents one of the targets for employing SSGs.

Assessing the agreement between a global navigation satellite system and an optical-tracking system for measuring total, high-speed running, and sprint distances in official soccer matches.

This study aimed to compare the agreement of total distance (TD), high-speed running (HSR) distance, and sprint distance during 16 official soccer matches between a global navigation satellite system (GNSS) and an optical-tracking system. A total of 24 male soccer players, who are actively participating in the Polish Ekstraklasa professional league, were included in the analysis conducted during official competitions. The players were systematically monitored using Catapult GNSS (10-Hz, S7) and Tracab optical-tracking system (25-Hz, ChyronHego). TD, HSR distance, sprint distance, HSR count (HSRC), and sprint count (SC) were collected. The data were extracted in 5-min epochs. A statistical approach was employed to visually examine the relationship between the systems based on the same measure. Additionally, R2 was utilized as a metric to quantify the proportion of variance accounted for by a variable. To assess agreement, Bland-Altman plots were visually inspected. The data from both systems were compared using the estimates derived from the intraclass correlation (ICC) test and Pearson product-moment correlation. Finally, a paired t-test was employed to compare the measurements obtained from both systems. The interaction between Catapult and Tracab systems revealed an R2 of 0.717 for TD, 0.512 for HSR distance, 0.647 for sprint distance, 0.349 for HSRC, and 0.261 for SC. The ICC values for absolute agreement between the systems were excellent for TD (ICC = 0.974) and good for HSR distance (ICC = 0.766), sprint distance (ICC = 0.822). The ICC values were not good for HSRCs (ICC = 0.659) and SCs (ICC = 0.640). t-test revealed significant differences between Catapult and Tracab for TD (p < 0.001; d = -0.084), HSR distance (p < 0.001; d = -0.481), sprint distance (p < 0.001; d = -0.513), HSRC (p < 0.001; d = -0.558), and SC (p < 0.001; d = -0.334). Although both systems present acceptable agreement in TD, they may not be perfectly interchangeable, which sports scientists and coaches must consider when using them.

Effects of combined plyometric, strength and running technique training program on change-of-direction and countermovement jump: A two-armed parallel study design on young soccer players.

CONTEXT AND OBJECTIVE: Players must be capable to have a good change-of-direction (COD) skill aiming to be the fastest as possible to react immediately to the opponent or even to help players to be more agile since COD is a physical determinant of agility. Thus, the aim of this study was to test the effects of a six-week combined training intervention in the COD and countermovement jump (CMJ) of young soccer players, while comparing with a control group only performing the regular field-based training sessions. METHODS: A sample of 80 non-professional players (40 experimental group and 40 control group) between the ages of ten and twelve was taken [(Age: 10.70 ± 1.02)]. The tests that were carried out from the beginning to the end of the intervention were: CMJ test, 505COD Test and Illinois Test. Paired sample t-test was used for determining differences as a repeated measures analysis (pre- post). An ANCOVA test was performed using the pretest as a covariate and the times pre and post as factors. RESULTS AND CONCLUSIONS: Repeated measures ANCOVA revealed significant influence of baseline level on the 5-0-5 COD (p = 0.001; ηp2=0.170), the Illinois (p = 0.018; ηp2=0.070) and the CMJ (p = 0.047; ηp2=0.050). Significant interactions group*time (p < 0.001; ηp2=0.137), 5-0-5 COD (p < 0.001; ηp2=0.274), and CMJ (p < 0.001; ηp2=0.392) were found, while no significant interactions were found in Illinois (p = 0.293; ηp2=0.014). The current research revealed that a combined training intervention consisting of strength training, plyometrics, and running techniques can be significantly beneficial for improving COD performance and CMJ.

Match running performance profiles of amputee football players at the national level.

Even though running performance and positional profiles in football are well described, amputee football (AF) has different characteristics of the movement, pitch dimensions, and time played. There is a gap in the scientific literature about positional profiles based on running performance in AF. This study aimed to investigate the differences between positions, the influence of the amputation level or defect of the lower limb (LD), the differences in running performance between halves, and the relationship with the final match result. Thirteen AF National Team players were monitored by Global Navigation Satellite System (GNSS), tracking 24 official international matches for 17 months. Values of top speed, peak acceleration, peak deceleration, average distance per minute, sprint mean speed, GPS load per minute, inertial load per minute (Gs load/min), number of sprints per minute, and a number of impacts per minute were analyzed for defenders (DEF), midfielders (MID) and forwards (FOR). Additional factors analyzed were amputation level (below the knee, low amputation-LA or over the knee, high amputation-HA or defect of the lower limb-LD) and the match's final result. Midfielders had significantly higher running performance parameters compared to other positions (greater top speed than DEF (+ 0.3 m/s; p < 0.001) and FOR (+ 0.2 m/s; p = 0.045), greater peak acceleration and deceleration than DEF (+ 0.5 m/s2 for both measures; p < 0.001) and FOR (+ 0.4 and + 0.3 m/s2; p < 0.001 and p = 0.036, respectively), greater GPS load/minute than DEF (+ 0.2 load/min; p = 0.001) and FOR (+ 0.3 load/min; p < 0.001), greater Gs load per minute than DEF (+ 2.7 load/min; p < 0.001) and FOR (+ 1.8 load/min; p < 0.001), greater number of impacts per minute than DEF (+ 0.2 n/min; p < 0.001) and FOR (+ 0.2 n/min; p < 0.001). Players with LD had significantly higher running performance than those with LA or HA. In the match's second half, a decrease in running performance was registered. The trend of running more when losing could be observed-AF players had higher running parameters in lost matches, but the differences were not statistically significant. Further research complied with contextual game analysis is needed to assess the running performance of AF players deeply.

Effects of horizontal compared to vertical-based plyometric jump training on semi-professional soccer player's performance.

This study aimed to compare the effects of horizontal (HJ) and vertical (VJ)-based plyometric jump training on male semi-professional soccer player's performance (e.g., change-of-direction speed [5-0-5 test]; 10-m, 20-m, and 30-m linear sprint speed). A parallel-study design was conducted. Participants were organized into HJ (n = 10) or VJ (n = 9) during 12 weeks. Measures of athletic performance were obtained in four phases: (i) before and (ii) end of the pre-season, (iii) during (weeks 7th), and (iv) after the intervention. The within-group analysis revealed that both HJ and VJ improved change of direction ([Formula: see text] = 27.783; p < 0.001 ([Formula: see text] = 21.635; p < 0.001),), 10-m linear sprint time ([Formula: see text] = 28.576; p < 0.001), 20-m linear sprint time ([Formula: see text] = 28.969, p < 0.001), and 30-m linear sprint time ([Formula: see text] = 26.143; p < 0.001). Similarly, the VJ-group also imposed significant changes on 5-0-5 time, 10-m linear sprint time ([Formula: see text] = 25.787; p < 0.001), 20-m linear sprint time ([Formula: see text] = 24.333, p < 0.001), and 30-m linear sprint time ([Formula: see text] = 22.919; p < 0.001). Between-group analysis revealed no significant differences in any of the assessment moments. HJ and VJ plyometric jump training are effective for improving the change-of-direction and a linear sprint of semi-professional players with no difference between types of intervention.

Evaluation of Reaction Time during the One-Leg Balance Activity in Young Soccer Players: A Pilot Study.

This study's aim was two-fold: (i) to test the intra-session reliability of the one-leg balance activity test; and (ii) to assess the influence of age on reaction time (RT) and the differences between dominant and non-dominant feet. Fifty young soccer players with an average age of 12.4 ± 1.8 years were divided into two groups: younger soccer players (n = 26; 11.6 ± 0.9 years) and older soccer players (n = 24; 14.2 ± 0.8 years). Each group then completed four trials (two with each leg) of the one-leg balance activity (OLBA) to evaluate RT under a single-leg stance. Mean RT and the number of hits were calculated, and the best trial was also selected. T-tests and Pearson correlations were performed for statistical analysis. Values for RT were lower, and the number of hits was higher while standing on the non-dominant foot (p = 0.01). MANOVA revealed that the "Dominant Leg" factor did not affect the multivariate composite (Pillai Trace = 0.05; F(4, 43) = 0.565; p = 0.689; Partial ETA Squared = 0.050; Observed Power = 0.174). The "Age" factor did not present an effect on the multivariate composite (Pillai Trace = 0.104; F(4, 43) = 1.243; p = 0.307; Partial ETA Squared = 0.104; Observed Power = 0.355). The results of the present investigation demonstrate that RT may be lower while standing on the non-dominant foot.

Assessment of asymmetry at different intensities between conventional and paralympic powerlifting athletes.

Powerlifting competitions require consistent and symmetric lifting of heavy loads and maximal effort, in which, asymmetric lifting results in trial invalidation. Symmetry during this very high intensity movement is determinant to athletes' performance and success in competitions. This study aimed to compare the asymmetry between Conventional Powerlifting athletes (CP) and Paralympic (PP) athletes at intensities of 45 and 80% 1RM before and after a training session. Twenty-two male athletes (11 CP: 29.84 ± 4.21 and 11 PP: 30.81 ± 8.05 years old) participated in this study. Mean Propulsive Velocity (MPV), Maximum Velocity (Vmax) and Power during the concentric and eccentric phases were evaluated at 45%-1RM before and after a training session. For the intensity of 80%-1RM, MPV, Vmax and Power were measured in the first and last series (5 series of 5 repetitions: 5X5) of a training session. PP athletes demonstrated lower velocity and greater symmetry at 45%-1RM, but higher velocity and less asymmetry at 80%-1RM, when compared to CP. The data indicated that PP athletes tend to be slower at lower intensities, faster at higher intensities in absolute values, and have greater symmetry than CP.

An Explanatory Model of Violent Behavior, Self-Concept, and Alcohol, Tobacco, and Cannabis Consumption in Secondary Education Students.

Background: Current scientific evidence establishes that regular physical activity engagement provides numerous physical and mental benefits. Thus, the present research aims at examining the relationships between violent behavior, self-concept, and consumption of alcohol, tobacco, and cannabis. Specifically, two objectives were defined: (a) analyze and establish the relationships between violent behaviors, the different dimensions of self-concept, and the consumption of alcohol, tobacco, and cannabis as a function of physical activity engagement, (b) define and examine a proposed explanatory model, and (c) analyze the effect of self-concept on alcohol and tobacco consumption and physical activity engagement based on the explanatory model developed. Methods: For this purpose, a nonexperimental (ex post facto), descriptive, and cross-sectional study was conducted. For data collection, a sociodemographic questionnaire was administered alongside the Self-Concept Form 5 and the School Victimization Scale. Results: It was shown that individuals engaging in more than three hours of physical exercise per week scored more highly on the social, family, physical, and emotional aspects of self-concept, whilst those who do not meet this criterion scored more highly on the academic aspect and on physical and verbal victimization. Conclusions: The present research concludes that engagement in more than 3 hours of physical activity per week led to benefits in a number of domains of self-concept whilst, at the same time, increasing levels of violence.

Using inertial measurement units for quantifying the most intense jumping movements occurring in professional male volleyball players.

The purpose of this study was to use an inertial measurement unit (IMU) to analyze variations in the jump outcomes concerning weekly training days, and the dependencies between the number of jumps per minute and the jump height. An experimental research design was adopted across three weeks of the final play-off of a volleyball championship. Through an IMU, the external load of seven male elite volleyball athletes of a top rating team from Portuguese 1st Division (age: 30.5 ± 3.5 years; height: 200.2 ± 6.3 cm; body mass: 93.0 ± 8.1 kg; BMI: 23.1 ± 2.3 kg/m2) was monitored. Repeated measures ANOVA was executed to compare the outcomes between training days. It was observed a similar density of jumps during the week. However, when comparing MD-1 to MD-2, a more significant average number of jumps per minute was observed in MD-1 (1.3 ± 0.2 vs. 1.0 ± 0.2). Additionally, a positive, large and significant correlation was registered between the number of jumps and the height of the jump. Those results highlight the benefits of the specific training, leading to greater stimulation and improvement, in a game-like context, of the stretching-shortening cycle, observed in every jump action in volleyball.

Relationship between cognitive functioning and physical fitness in regard to age and sex.

The aim of this study was to analyze the relationships among physical cognitive ability, academic performance, and physical fitness regarding age and sex in a group of 187 students (53.48% male, 46.52% female) from one town of Norwest of Jaén, Andalusia (Spain), aged between 9 and 15 years old (M = 11.97, SD = 1.99). The D2 attention test was used in order to analyze selective attention and concentration. Physical fitness, reflected on maximal oxygen uptake (VO2max), was evaluated using the 6 min Walking Test (6MWT). The analysis taken indicated a significant relationship between physical fitness level, attention, and concentration, as in the general sample looking at sex (finding differences between boys and girls in some DA score in almost all age categories [p < 0.05]) and at age category (finding some differences between the younger age category groups and the older age category groups in some DA scores (p < 0.05), not finding any significant interaction between sex and age category (p > 0.05). In sum, the present study revealed that students with better aerobic fitness can present better-processed elements and smaller omission errors. Moreover, girls and older students seem to present better cognitive functioning scores than boys and younger. Our findings suggest that more research is necessary to elucidate the cognitive function between ages, sexes, and physical fitness and anthropometry levels of students.

Acute effect of moderate and high-intensity interval exercises on asprosin and BDNF levels in inactive normal weight and obese individuals.

This study aimed to examine the acute effects of moderate-intensity aerobic and high-intensity interval exercise protocols on Asprosin and Brain-Derived Neurotrophic Factor (BDNF) levels in inactive normal weight and obese individuals. A total of 20 male individuals aged 18-65 years, ten normal weight (NW) (Body Mass Index (BMI): 18.5-24.99 kg/m2) and 10 obese (Ob) (BMI: 24.99-35.00 kg/m2) participated in this study, voluntarily. Moderate aerobic exercise (AE) (main circuit 30 min, between 40 and 59% of Heart Rate Reserve: HRR) and High-Intensity Interval exercise (HIIE) running protocols (main circuit 20 min, between 75 and 90% of the HRR for 1 min*10 times, and 1-min active rest at 30% of the HRR) was applied to the volunteer participants in the morning hours (08.00-10.00 a.m.), following the night fasting (at least 8-10 h) for at least 3 days between each other. Blood samples were collected from the participants before and immediately after each exercise protocol, and serum asprosin and BDNF hormone levels were determined by Enzyme-Linked Immunosorbent Assay" method. Basal serum asprosin was found to be significantly higher in the Ob group compared to the NW group (p < .001), while the basal serum BDNF hormone was found to be lower (p < 0.05). It was observed that the serum asprosin level of both groups decreased significantly after both AE and HIIE protocols (p < 0.05). In addition, there was a significantly higher decrease in serum asprosin level in the Ob group compared to the NW group after HIIE protocol. For the Ob group, serum BDNF level increased considerably after HIIE protocol compared to AE protocol (p < 0.05). Serum asprosin was found to be higher in the Ob group, while the serum BDNF was found to be lower. In addition, the acute exercises of different intensity significantly affected hormones that regulate appetite metabolism. In particular, it was observed that the HIIE protocol had a greater effect on the regulation of appetite (hunger-satiety) in the Ob group. This result can be taken into account when planning training programs for these individuals.

Cooperative antibiotic resistance facilitates horizontal gene transfer.

The rise of ß-lactam resistance among pathogenic bacteria, due to the horizontal transfer of plasmid-encoded ß-lactamases, is a current global health crisis. Importantly, ß-lactam hydrolyzation by ß-lactamases, not only protects the producing cells but also sensitive neighboring cells cooperatively. Yet, how such cooperative traits affect plasmid transmission and maintenance is currently poorly understood. Here we experimentally show that KPC-2 ß-lactamase expression and extracellular activity were higher when encoded on plasmids compared with the chromosome, resulting in the elevated rescue of sensitive non-producers. This facilitated efficient plasmid transfer to the rescued non-producers and expanded the potential plasmid recipient pool and the probability of plasmid transfer to new genotypes. Social conversion of non-producers by conjugation was efficient yet not absolute. Non-cooperative plasmids, not encoding KPC-2, were moderately more competitive than cooperative plasmids when ß-lactam antibiotics were absent. However, in the presence of a ß-lactam antibiotic, strains with non-cooperative plasmids were efficiently outcompeted. Moreover, plasmid-free non-producers were more competitive than non-producers imposed with the metabolic burden of a plasmid. Our results suggest that cooperative antibiotic resistance especially promotes the fitness of replicons that transfer horizontally such as conjugative plasmids.