Atypical oral features of patient with neurofibromatosis type 1: case report / Características orais atípicas de paciente com neurofibromatose tipo 1: relato de caso

RESUMEN El propósito de este artículo es ayudar a los dentistas clínicos a identificar la neurofibromatosis tipo 1 y sus variantes. Presentamos un caso raro de un hombre de 68 años, afectado desde la infancia por la presencia de nódulos generalizados en todo el cuerpo, provocando deformaciones estéticas. Curiosamente, el impacto en la cavidad oral no fue significativo, con nódulos solo en la encía, un área de manifestación raro. La radiografía panorámica mostró un ligero agrandamiento del canal mandibular. Tras un año de seguimiento, el paciente falleció por complicaciones cardiovasculares provocadas por el síndrome.

Large calcifying odontogenic cyst in the posterior maxilla / Extenso cisto odontogênico calcificante em maxila posterior

RESUMEN La aparición de un quiste odontogénico calcificante (QOC) en la región posterior de la maxila es infrecuente; hay pocos informes descritos en la literatura. Presentamos el caso de una paciente de 13 años que presentó una lesión extensa en la maxila izquierda (> 7,5 cm). La radiografía panorámica mostró una lesión radiolúcida unilocular bien delimitada, que se extendía desde el maxilar posterior izquierdo hasta el seno maxilar. La paciente fue sometida a descompresión, seguida de de la extirpación quirúrgica conservadora de la lesión. El análisis histológico de la pieza quirúrgica confirmó el diagnóstico de QOC. Después de un año, no se observaron recurrencias. La paciente permanece en seguimiento regular.

Anti-Inflammatory Activity of Limonene in the Prevention and Control of Injuries in the Respiratory System: A Systematic Review.

INTRODUCTION: The pulmonary inflammatory response results from exposure to injurious factors and is associated with oxidative stress, which intensifies the pathological reaction. In this context, limonene, a monoterpene found in citrus fruits, can be a therapeutic alternative for the treatment of this pathology, as it presents known anti-inflammatory and antioxidant actions. OBJECTIVE: The purpose of this article is to provide an overview of the anti-inflammatory activity of limonene and its capacity to prevent and control respiratory system injuries. SEARCH STRATEGY: A comprehensive literature search of the Cochrane, Scopus, MEDLINE-PubMed, Web of Science, and Lilacs databases was performed using the keywords: "limonene", "lung", "pulmonary", "airway", "trachea", "lung injury", "respiratory system", "respiratory tract diseases". SELECTION CRITERIA: Studies on the use of limonene in disorders of the respiratory system, published until August 2019, were included. Those that did not use limonene alone or treated lesions in different systems other than the respiratory system, without targeting its anti-inflammatory action were excluded. In addition, review articles, meta-analyses, abstracts, conference papers, editorials/letters and case reports were also excluded. RESULTS: Of the 561 articles found, 64 were in the Cochrane database, 235 in Scopus, 99 in Web of science, 150 in PubMed and 13 in Lilacs. After completing the systematic steps, 25 articles were selected for full reading, after which 7 papers remained in the review. An article was added after a manual literature search, resulting in a total of 8 papers. There was a high level of agreement on inclusion/exclusion among the researchers who examined the papers (Kappa index > 88%). CONCLUSION: Limonene has effective anti-inflammatory activity in both preventing and controlling respiratory system injuries.

Effects of the solid lipid nanoparticle of carvacrol on rodents with lung injury from smoke inhalation.

The aim of this present study was to evaluate the effect of solid lipid nanoparticles (SLN) containing carvacrol over the lung damage of airway smoke inhalation. The study was conducted with 30 rats subjected to smoke inhalation and divided into 5 groups such as, normal control, negative control, oxygen group, SLN alone, and SLN+CARV group. The animals were sacrificed 24 h after the induction of inhalation injury further, the tissues of larynx, trachea, and lungs were collected for the histological, hematological, myeloperoxidase, and malondialdehyde analysis. The obtained results showed that treatment with CARV+SLN minimized the inhalation injury, since it reduced malondialdehyde significantly, when compared to the negative control group and minimized the histological changes which proves the absence of pulmonary emphysema and exudate in laryngeal and tracheal lumen in the CARV+SLN-treated group. Meanwhile, the presence of lesion with chronic characteristics was observed in the negative control and oxygen groups. It is suggested that the SLN containing carvacrol minimized oxidative stress and histological damages generated from smoke inhalation in rodents.

Transtornos mentais comuns em médicos e seu cotidiano de trabalho / Common mental disorders among physicians and their everyday practice

OBJETIVO: Comparar o cotidiano de trabalho e a prevalência dos transtornos mentais comuns (TMC) dos médicos que exerciam suas atividades profissionais no serviço de emergência com os da UTI e enfermarias de um hospital geral da rede estadual em Recife, em 2004. MÉTODOS:Estudo de prevalência tendo utilizado como instrumentos um questionário sobre o Cotidiano de Trabalho Médico e o Self Reporting Questionnaire (SRQ-20), para identificar os TMC. Foram descritas características demográficas, socioeconômicas e do cotidiano de trabalho dos médicos do hospital. Calculou-se a prevalência global dos TMC e por setor de trabalho. RESULTADOS: Comparando os médicos da emergência com os da UTI e enfermarias, aqueles tinham vínculo empregatício com o Estado (p < 0,0001), múltiplos empregos (p = 0,004), maior carga horária semanal de trabalho (> 71 horas) (p = 0,007), maior sensação de sobrecarga de trabalho (95,74 por cento, p = 0,015) e recebiam no hospital até 5 salários mínimos (p < 0,0001). Embora a diferença não tenha sido estatisticamente significante, a prevalência de TMC foi maior nos médicos da emergência (32,00 por cento), comparando-se aos da UTI (17,65 por cento) e enfermarias (17,54 por cento). CONCLUSÃO: Identificou-se a emergência como setor de maior prevalência de TMC e com médicos vivenciando piores condições de trabalho.

OBJECTIVE: To compare the day-to-day workload and prevalence of common mental disorders (CMD) among physicians that exercise their professional activities in the emergency service with those of the ICU and infirmaries of a state-run general emergency hospital in the city of Recife in 2004. METHODS: Cross-sectional study which used a questionnaire elaborated to obtain information on the PhysicianÆs Day-to-day Workload and the Self Reporting Questionnaire (SRQ-20), to identify CMD. Demographic, socio-economic and day-to-day workload characteristics of the physicians of the hospital were described. The global prevalence of CMD and stratified by working sector was calculated. RESULTS: Comparing the physicians of the emergency service with those of the ICU and infirmaries, the formers worked for the state (p < 0.0001), had multiple jobs (p = 0.004), had a greater weekly workload (> 71 hours) (p = 0.007), presented a greater sensation of being overworked (95.74 percent, p = 0.015) and received up to 5 times the minimum salary at the hospital (p < 0.0001). Although the difference was not statistically significant, the prevalence of CMD was higher among those physicians in the emergency service (32.00 percent) in comparison to those of the ICU (17.65 percent) and the infirmaries (17.54 percent). CONCLUSION: The emergency service was identified as the sector with the highest prevalence of CMD and with physicians experiencing the worst day-to-day working conditions.