Flavonoids from Brazilian Cerrado: Biosynthesis, Chemical and Biological Profile.

Flavonoids are highly bioactive compounds with very low toxicity, which makes them attractive starting points in drug discovery. This study aims to provide information on plant species containing flavonoids, which are found in the Brazilian Cerrado. First, we present the characterization and plant diversity with emphasis on the families of flavonoid-producing plants, and then we describe the phenylpropanoid pathway which represents the flavonoids' main route biosynthesis-generally conserved in all species. Chemical structures and biological activities of flavonoids isolated from the Cerrado's plant species are also described based on examples from the relevant literature studies. Finally, research on the biodiversity of the Cerrado biome should be encouraged, due to the discovery of new sources of flavonoids which can provide several benefits to human health and the possibility of developing new drugs by the pharmaceutical industry.

O cerrado goiano na literatura de Bernardo Élis sob o olhar da história ambiental / The cerrado of Goiás in the literature of Bernardo Élis, from a viewpoint of environmental history

Resumo O artigo analisa as representações de natureza na literatura de Bernardo Élis, a partir dos pressupostos teóricos e metodológicos da história ambiental. Élis fez parte de um grupo de intelectuais que apresentava, por meio da literatura, as condições de vida na fronteira goiana e as relações humanas nessas paisagens “gerais”. Nas gerais, os dramas de suas personagens misturavam-se ao ambiente físico do cerrado, numa narrativa realista e denunciadora das condições de vida na isolada fronteira (ermos e gerais). Em seu diálogo com a literatura, os fundamentos desse campo da pesquisa historiográfica podem ser adotados como instrumentos analíticos, aliados a concepções relativas à integração entre sociedade e natureza, como as de fronteira e wilderness.

Abstract This article analyzes the representations of nature in the literature of Bernardo Élis based on the theoretical and methodological assumptions of environmental history. Élis was part of a group of intellectuals whose literature presented the living conditions in the frontier of Goiás and the human relationships occurring in these landscapes. In these scrublands, the dramas of their characters are mixed with the physical environment of the cerrado region in a realistic narrative denouncing the living conditions in this isolated frontier area. In their dialog with literature, the fundamentals of this field of historiographic research can be adopted as analytical instruments, combined with concepts related to the integration between society and nature, such as the frontier and wilderness.

The cerrado of Goiás in the literature of Bernardo Élis, from a viewpoint of environmental history. / O cerrado goiano na literatura de Bernardo Élis sob o olhar da história ambiental.

This article analyzes the representations of nature in the literature of Bernardo Élis based on the theoretical and methodological assumptions of environmental history. Élis was part of a group of intellectuals whose literature presented the living conditions in the frontier of Goiás and the human relationships occurring in these landscapes. In these scrublands, the dramas of their characters are mixed with the physical environment of the cerrado region in a realistic narrative denouncing the living conditions in this isolated frontier area. In their dialog with literature, the fundamentals of this field of historiographic research can be adopted as analytical instruments, combined with concepts related to the integration between society and nature, such as the frontier and wilderness.

A medicina pionera: protestantismo e prática médica na expansão da fronteira em Goiás na primeira metade do século XX / The pioneering medicine: Protestantism and medical practice in the expansion of the border in Goiás in the first half of the XX century

Analisa a relação entre os processos de ocupação humana e a sua interação com o meio natural. Nesse sentido, é importante apresentarmos o que consideramos como Medicina de Fronteira e sua vinculação com o ethos protestante, ou à medicina como vocação. Apresenta o discurso sobre a medicina em Goiás sob a ótica do médico inglês James Fastone, o poder simbólico na Colônias Agrícolas Nacionais de Goiás.(AU)