ABSTRACT
ABSTRACT Objective: To estimate the magnitude of the association between Autism Spectrum Disorder (ASD) and postnatal factors in a Brazilian population. Methods: A case-control study was performed with 253 individuals diagnosed with ASD and 886 individuals without signs of the disorder. A semi-structured questionnaire and the multiple logistic regression model were adopted in the data analysis. To estimate the magnitude of associations, the crude and adjusted Odds Ratio (OR) was used. Results: An association with the following factors was found: having been born with congenital malformation (OR 4.24; confidence interval of 95% - 95%CI 1.92-9.34), neonatal jaundice (OR 1.43; 95%CI 1.01-2.02), absence of crying at birth and seizure episode in childhood (OR 5.75; 95%CI 3.37-9.81). The magnitude of the association was higher in the children/adolescents who had two or more postnatal complications (OR 6.39; 95%CI 4.10-10.00). Conclusions: The findings of the present study suggest that malformation, neonatal jaundice, absence of crying at birth and seizure episodes in childhood are important factors to be considered when studying the etiology of ASD.
RESUMO Objetivo: Estimar, em uma população brasileira, a magnitude da associação entre o transtorno do espectro do autismo (TEA) e os fatores pós-natais. Métodos: Estudo de caso controle realizado com 253 indivíduos com diagnóstico do TEA e 886 sem sinais do transtorno. Foi aplicado um questionário semiestruturado e adotou-se o modelo de regressão logística múltipla na análise dos dados. Para estimar a magnitude das associações, utilizou-se a razão de chances (Odds Ratio - OR) bruta e ajustada. Resultados: Encontrou-se associação de TEA com os seguintes fatores: ter nascido com má-formação congênita (OR 4,24; intervalo de confiança de 95% - IC95% 1,92-9,34), icterícia neonatal (OR 1,43; IC95% 1,01-2,02), ausência de choro ao nascer (OR 1,97; IC95% 1,20-3,23) e episódio de convulsão na infância (OR 5,75; IC95% 3,37-9,81). A magnitude da associação foi maior nas crianças/adolescentes que tiveram duas ou mais complicações pós-natais (OR 6,39; IC95% 4,10-10,00). Conclusões: Os achados do presente estudo sugerem que má-formação, icterícia neonatal, ausência de choro ao nascer e episódios de convulsão na infância são fatores importantes a serem considerados ao estudar a etiologia do TEA.
Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Autism Spectrum Disorder/etiology , Brazil , Case-Control Studies , Logistic Models , Odds Ratio , Risk Factors , Autism Spectrum Disorder/diagnosisABSTRACT
OBJECTIVE: To estimate the magnitude of the association between Autism Spectrum Disorder (ASD) and postnatal factors in a Brazilian population. METHODS: A case-control study was performed with 253 individuals diagnosed with ASD and 886 individuals without signs of the disorder. A semi-structured questionnaire and the multiple logistic regression model were adopted in the data analysis. To estimate the magnitude of associations, the crude and adjusted Odds Ratio (OR) was used. RESULTS: An association with the following factors was found: having been born with congenital malformation (OR 4.24; confidence interval of 95% - 95%CI 1.92-9.34), neonatal jaundice (OR 1.43; 95%CI 1.01-2.02), absence of crying at birth and seizure episode in childhood (OR 5.75; 95%CI 3.37-9.81). The magnitude of the association was higher in the children/adolescents who had two or more postnatal complications (OR 6.39; 95%CI 4.10-10.00). CONCLUSIONS: The findings of the present study suggest that malformation, neonatal jaundice, absence of crying at birth and seizure episodes in childhood are important factors to be considered when studying the etiology of ASD.
Subject(s)
Autism Spectrum Disorder/etiology , Adolescent , Autism Spectrum Disorder/diagnosis , Brazil , Case-Control Studies , Child , Child, Preschool , Female , Humans , Logistic Models , Male , Odds Ratio , Risk FactorsABSTRACT
OBJECTIVE: To identify factors associated with self-perceived oral health among Brazilian elderly individuals. METHODS: Data from the Projeto SB Brasil (Brazilian Oral Health Project), conducted in 2002-2003, were used. A probabilistic sample of 5,349 elderly individuals, aged between 65 and 74 years, was analyzed, interviewed and subsequently grouped into dentate and edentate individuals. The dependent variable was self-perceived oral health condition, while independent variables were as follows: place of residence, individual characteristics, health-related behavior, objective health conditions and subjective health conditions. Descriptive and hierarchical multiple linear regression analyses were performed. RESULTS: In both groups, self-perceived oral health was considered positive, despite the poor oral health conditions found among the elderly. In the final model, place of residence and individual characteristics contributed little to explain the variability of self-perception. The use of dental services was associated with the outcome in dentate individuals, while objective and subjective conditions were associated in both groups. Among dentate and edentate individuals, R² for the external environment was 0.00; with the inclusion of individual characteristics, 0.05 and 0.02, respectively; with the inclusion of health-related behavior, 0.06 and 0.03, respectively; with the inclusion of objective health conditions, 0.11 and 0.04 respectively; and with the inclusion of subjective health conditions, 0.50 and 0.43, respectively. It was possible to explain 50% of the variability of self-perception in dentate individuals, and 43% in edentate ones. CONCLUSIONS: The main factors associated with self-perceived oral health in both groups were excellent self-perceived appearance, followed by positive self-perceived mastication. The third associated factor was reporting no need for dental treatment in dentate individuals, and self-perceived speech in edentate ones.
Subject(s)
Dental Health Surveys , Diagnostic Self Evaluation , Oral Health , Aged , Attitude to Health , Brazil , Dental Care for Aged/statistics & numerical data , Female , Humans , Male , Socioeconomic FactorsABSTRACT
OBJETIVO: Identificar os fatores associados à autopercepção da saúde bucal entre idosos brasileiros. MÉTODOS: Utilizaram-se dados do Projeto SB Brasil, realizado em 20022003. Foi examinada e entrevistada amostra probabilística de 5.349 idosos de 65 a 74 anos agrupados em dentados e edentados. A variável dependente foi autopercepção da condição de saúde bucal e as independentes foram: local de moradia, características individuais, comportamentos relacionados à saúde, condições objetivas de saúde e condições subjetivas relacionadas à saúde. Foram conduzidas análises descritivas e análises de regressão linear múltipla hierárquica. RESULTADOS: Nos dois grupos a autopercepção da saúde bucal foi considerada positiva, apesar das precárias condições de saúde bucal entre os idosos. No modelo final, o local de moradia e as características individuais pouco contribuíram para explicar a variabilidade da autopercepção. Entre dentados, o uso de serviços odontológicos esteve associado ao desfecho, e as condições objetivas e subjetivas se mostraram associadas nos dois grupos. Entre dentados e edentados, o R² para o ambiente externo foi de 0,00; com o acréscimo das características individuais, respectivamente, 0,05 e 0,02; incluindo o comportamento relacionado à saúde, 0,06 e 0,03; acrescentando as condições objetivas de saúde, 0,11 e 0,04; adicionando as condições subjetivas relacionadas à saúde foram 0,50 e 0,43. Foi possível explicar 50 por cento da variabilidade da autopercepção entre dentados e 43 por cento entre edentados. CONCLUSÕES: Os principais fatores associados à autopercepção da saúde bucal como positiva nos dois grupos foram a autopercepção da aparência como ótima seguida pela autopercepção da mastigação como positiva. O terceiro fator associado, entre dentados, foi o relato de nenhuma necessidade de tratamento odontológico e, entre edentados, a autopercepção da fala.
