ABSTRACT
Pieces of polyurethane, Teflon, silicone, and polyvinyl chloride were placed intraperitoneally to compare the histologic findings regarding intraperitoneal adhesion development in a rat model. The overall adhesion score differed significantly among the groups, the highest being in the Teflon group (mean 13.2), followed in descending order by the polyvinyl chloride group (10), the silicone group (9.6), and the polyurethane group (6.8). Thus, polyurethane causes the least adhesion development and can be used more extensively for the construction of catheters for intraperitoneal use.
Subject(s)
Catheterization/adverse effects , Catheterization/instrumentation , Peritoneal Cavity/pathology , Tissue Adhesions/pathology , Animals , Disease Models, Animal , Female , Polytetrafluoroethylene , Polyurethanes , Rats , Rats, Wistar , SiliconesABSTRACT
To compare the adhesion formation, in a rat model, of commercially available materials used as intraperitoneal catheters in clinical practice, pieces of polyurethane, Teflon, silicone, and polyvinyl chloride (PVC) were placed intraperitoneally in 36 female Wistar rats randomly assigned into four groups. Adhesion development was quantitated according to Nair's classification system (NCS). According to NCS, polyurethane showed the least adhesion formation, while the highest scores were found in the PVC group. Comparing the thickness and the firmness of adhesions in the four groups, significant differences were found, with the polyurethane group developing none or filmy and mild adhesions. In contrast, almost all the rats in the Teflon group developed thick and dense adhesions. Thus, polyurethane caused the least adhesion formation among the four materials evaluated, and can be used more extensively for the construction of catheters for prolonged intraperitoneal use.