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CLL/SLL diagnosed in an adolescent.
Luskin, Marlise; Wertheim, Gerald; Morrissette, Jennifer; Daber, Robert; Biegel, Jaclyn; Wilmoth, Donna; Kersun, Leslie; King, Rebecca; Paessler, Michele; Simon, Cara; Aplenc, Richard; Loren, Alison.
Pediatr Blood Cancer ; 61(6): 1107-10, 2014 Jun.
Article in English | MEDLINE | ID: mdl-24281971

ABSTRACT

Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a disease of older adults. Pediatric CLL/SLL is vanishingly rare in the literature. We present a case of CLL/SLL diagnosed in a 17-year-old male. The pathologic findings of this case were those of classic CLL/SLL with an ATM deletion, a characteristic genetic abnormality in CLL/SLL. Management guidelines for CLL/SLL are tailored to older adults making determination of the optimal therapy for this patient a unique challenge.


Subject(s)
Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis , Adolescent , Age Factors , Ataxia Telangiectasia Mutated Proteins/genetics , Biomarkers, Tumor , Chromosomes, Human, Pair 11/genetics , Chromosomes, Human, Pair 11/ultrastructure , Chromosomes, Human, Pair 8/genetics , Chromosomes, Human, Pair 8/ultrastructure , Diagnostic Imaging , Gene Dosage , Genes, myc , Humans , Immunophenotyping , In Situ Hybridization, Fluorescence , Leukemia, Lymphocytic, Chronic, B-Cell/epidemiology , Leukemia, Lymphocytic, Chronic, B-Cell/genetics , Lymph Nodes/pathology , Male , Sequence Deletion
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