ABSTRACT
The article deals with the results of experimental study of adaptation reactions in mild craniocerebral trauma (MCCT) combined with acute alcoholic intoxication on the basis of appraisal of the dynamics of endocrine and neuromediator shifts. A stress character of these shifts was revealed. Acute alcoholic intoxication levelled the stress reaction occurring in MCCT.
Subject(s)
Adaptation, Physiological , Alcoholic Intoxication/physiopathology , Brain Injuries/physiopathology , Adrenal Glands/physiopathology , Animals , Disease Models, Animal , Male , Rats , Rats, Inbred Strains , Stress, Physiological/physiopathology , Thyroid Gland/physiopathology , Time FactorsABSTRACT
Antiseptic gelatin sponges with kanamycin and gentamicin, which were studied in experiments on animals and used in the clinic, are a reliable measure for the prevention of suppuration in craniocerebral surgery in planned operations and in combination with debridement in penetrating injury of the skull and brain. For therapeutic purposes, local application of the agents is effective in focal suppurative processes in the skull and brain after surgical debridement of the purulent focus (abscess of the brain, osteomyelitis of the skull, etc.).