ABSTRACT
Bisphosphonates (BPs) are a time-tested drug class with multivariate use cases. They are used in pathologies ranging from osteoporosis to Paget's disease, and also help in accelerated fracture healing. They have been used to treat both benign and malignant lesions of the skeletal system since a long time. However, there have been reports of increased incidences of atypical femoral fractures (AFFs) in patients exhibiting chronic use of bisphosphonates in the past years. This has led to the widespread dissuasion of physicians and practitioners from using the drug class. By means of this review of the literature, the authors aim to investigate the relationship between BP use and its association with AFFs. The review focuses on and elucidates the basic pharmacology of BPs and goes on to illustrate the indications of BPs in various pathologies of the musculoskeletal system, further exploring the effects of BPs on the healing of various bony fractures. The authors also explore the incidences of other pathologies, such as osteonecrosis of the jaw and nephropathies associated with BP use, and elaborate on their features. Through this review, the authors have tried to educate and induce critical thinking on the part of clinicians and medical professionals in regard to prescribing BPs to patients that need them, by keeping in mind the risk-reward relationship that accompanies their use.
ABSTRACT
Nicotine is used extensively across the globe despite the common awareness of the fact that it might stimulate the neurological system in those who indulge in its consumption. Nicotine can be consumed in a wide number of various forms and can also be delivered in a wide variety of different ways. After it has been heated, it can be smoked, consumed sublingually, or brought into touch with mucosal surfaces, with the buccal mucosa being the most popular one. These three methods of consumption account for the vast majority of its use. It has been demonstrated without a reasonable doubt that people who partake in nicotine do, in fact, experience an increase in their levels of alertness, wakefulness, attention, and focus. The half-life of the substance, in addition to its effects, is highly variable depending on the forms in which it is consumed, viz. cigarettes, tobacco, gums, lozenges, and the manner in which it is administered. This is the case regardless of whether the chemical is administered orally or intravenously. It is common for a person to require multiple "hits" of the chemical throughout the course of the day, though the frequency of these needs and the intervals between them can vary greatly. The time interval between each of these "hits" can range anywhere from a few hours to a few minutes. The user has the potential to develop a tolerance to the neurostimulatory and systemic effects of nicotine, as well as a heightened sensitivity to those effects, and even hereditary predispositions to specific adverse consequences. There is also a possibility that the user will develop an addiction to nicotine. This literature review aims to explore the relationship between nicotine consumption and its effects on the central nervous system, especially on sleep.
ABSTRACT
Palliative care is the need of the hour, especially in a country like India where the number of terminally ill patients has always been a concern, and with projections showing this number to only go up and increase exponentially, it is much more important that we now shift our focus to providing quality hospice care to the ones that are in need of it. In this article, the authors start out by defining Palliative care and hospice care, all the while maintaining the distinct features of them both. Once the foundation is set for the same, we dive into the history of palliative care in this country and how it has evolved over the years. We then move on to the present scenario of hospice care in India and try to look at it through a more contemporary lens. Further, we discuss the impact of some diseases that most adversely affect individuals and require end-of-life care in its more advanced stages. These include, but are not limited to, end-stage cancer, multidrug resistant (MDR)-tuberculosis and Human immunodeficiency virus-associated acquired immune deficiency syndrome (HIV-AIDS). We then move on to discuss the importance of academic interventions to strengthen the role of hospice care in the India and how research and education can help improve the condition of end-of-life care in all domains. We finally talk about how we can move forward and what positive changes we can bring about in order to make inroads into better and more sustainable hospice care in the Indian context. We hope that our work will cause healthcare professionals, and other people alike to better understand the role of hospice care in their own lives and livelihoods.
ABSTRACT
The condition of the world is different in the year 2021. People who were busy with their daily life and all the social activity have realized that tables can turn over at any moment of time. It's the COVID-19 pandemic this year. The world has seen the importance of health care workers all around the globe. All the countries have realized the importance of the health care sector along with the need to expand it further. The importance of spending more financially on a country's health care sector has become utmost important right now. At this time of emergency when humanity is foaling in a way which was never witnessed in the acts of violence against frontline workers, doctors are still not ready to give up on humanity. The human era has witnessed times when people used to laugh out loud about water being sold and now have come to witness such times when even a liter of oxygen is worth millions of Rupees, the conclusion being basic human amenities have started to fade away. Even after witnessing such crises around the globe, and the sacrifices of health care workers, people are still busy creating chaos for them or I would like to say "create a hell-like environment" for them to work in. Even after such a chaotic condition, health care workers are giving their best to control this health care emergency and since time immemorial, they are putting their life at risk for this society which are dwelling devils inside for them.
ABSTRACT
Health economics has long been neglected as a subset of the larger discipline of Economics and Finance. However, this could not be further from the truth. There is a large body of researchers and professionals alike that are of the consensus that extensive studying and working upon Healthcare Economics can help us avert the situation that arose in the wake of the recent COVID-19 pandemic. Applying the core principles of Health Economics to a situation like that would help avert bad outcomes. In this article, the authors begin by defining and establishing the concepts of Health Economics and then building on them. We further explain the concepts in light of the Indian Economy and Healthcare Sector and how it has seen unprecedented growth in the last decade. Furthermore, we touch on the various diseases that put the most strain on the healthcare infrastructure and what we can do to make the situation better. We also shed light on how the COVID-19 pandemic affected the Health Economics in the Indian setting and go on to elaborate how India managed to tackle it. Finally, we elaborate on what steps we can take, as researchers and healthcare professionals, to make it easier for the common man to get access to better and more economical healthcare. We determine the importance and effectiveness of data collection and processing and also how to make better research attempts to study, evaluate and process that said data. The onus falls on the academic and the healthcare professional to ensure that the true meaning of Health Economics is not reduced to a mere numbers game, but is something which is truly subjective and for the benefit of the masses.
