ABSTRACT
Thermoplastic composites are continuously replacing thermosetting composites in lightweight structures. However, the accomplished work on the fatigue behavior of thermoplastics is quite limited. In the present work, we propose a numerical modeling approach for simulating fatigue delamination growth and predicting the residual tensile strength of quasi-isotropic TC 1225 LM PAEK thermoplastic coupons. The approach was supported and validated by tension and fatigue (non-interrupted and interrupted) tests. Fatigue delamination growth was simulated using a mixed-mode fatigue crack growth model, which was based on the cohesive zone modeling method. Quasi-static tension analyses on pristine and fatigued coupons were performed using a progressive damage model. These analyses were implemented using a set of Hashin-type strain-based failure criteria and a damage mechanics-based material property degradation module. Utilizing the fatigue model, we accurately foretold the expansion of delamination concerning the cycle count across all interfaces. The results agree well with C-scan images taken on fatigued coupons during interruptions of fatigue tests. An unequal and unsymmetric delamination growth was predicted due to the quasi-isotropic layup. Moreover, the combined models capture the decrease in the residual tensile strength of the coupons. During the quasi-static tension analysis of the fatigued coupons, we observed that the primary driving failure mechanisms were the rapid spread of existing delamination and the consequential severe matrix cracking.
ABSTRACT
In the present work, a numerical model based on the cohesive zone modeling (CZM) approach has been developed to simulate mixed-mode fracture of co-consolidated low melt polyaryletherketone thermoplastic laminates by considering fiber bridging. A modified traction separation law of a tri-linear form has been developed by superimposing the bi-linear behaviors of the matrix and fibers. Initially, the data from mode I (DCB) and mode II (ENF) fracture toughness tests were used to construct the R-curves of the joints in the opening and sliding directions. The constructed curves were incorporated into the numerical models employing a user-defined material subroutine developed in the LS-Dyna finite element (FE) code. A numerical method was used to extract the fiber bridging law directly from the simulation results, thus eliminating the need for the continuous monitoring of crack opening displacement during testing. The final cohesive model was implemented via two identical FE models to simulate the fracture of a Single-Lap-Shear specimen, in which a considerable amount of fiber bridging was observed on the fracture area. The numerical results showed that the developed model presented improved accuracy in comparison to the CZM with the bi-linear traction-separation law (T-SL) in terms of the predicted strength of the joint.
ABSTRACT
The way thyroid hormone works in peripheral nerve regeneration has not been fully elucidated, although studies have shown that it has a strong positive effect on nerve regeneration. It is argued that its action is probably stronger than the neurotrophic factors that have been used for some time. It is hypothesized that the use of thyroid hormone in the nerve tubes has a beneficial effect on nerve regeneration to the extent that the results of its use are comparable to those of the autograft technique in bridging small nerve deficits. In this experimental study, we examined the effect of thyroid hormone and BDNF (Brain Derived Neurotrophic Factor) on the repair of 10 mm nerve defects when administered within silicone nerve tubes and compared the results with the autograft method. Thyroid hormone promotes nerve regeneration mainly by increasing its speed and its effect on the maturation of nerve fibers compared to the other groups where the nerve deficit was bridged by entubulation. Also, better organization and the absence of intraneural fibrosis, compared to the other groups, may argue for the action of thyroid hormone in regulating the inflammatory response. Functionally, the AG group showed better results compared to the other groups by the end of the study (16 weeks).
Subject(s)
Brain-Derived Neurotrophic Factor , Sciatic Nerve , Autografts , Humans , Nerve Regeneration , Silicones , Thyroid HormonesABSTRACT
Nonsteroidal anti-inflammatory drugs (NSAIDs) may prevent heterotopic ossification after total hip arthroplasty (THA). Cyclooxygenase 2 (COX-2) inhibitors may minimize side effects. The goal of this review was to compare the effectiveness and side effects of the perioperative use of selective COX-2 inhibitors with those of conventional NSAIDs in patients undergoing THA. We followed the systematic reviews' updated methods of the Cochrane Collaboration Back Review Group and searched MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials. We identified all randomized controlled trials until April 2009 enrolling THA patients and comparing COX-2 inhibitors to NSAIDs. We assessed their methodological quality and extracted data. Five randomized controlled trials were included. Prevention of heterotopic ossification and side effects with COX-2 inhibitors were significant in 2 studies. Discontinuation for side effects was not significant. COX-2 inhibitors do not prevent heterotopic ossification after THA significantly better than conventional NSAIDs, while they are advantageous regarding side effects.
