ABSTRACT
Nineteen children with childhood autism and 8 with Asperger's syndrome aged 2-8 year, were treated with cerebrolysin (CL) in inpatient clinic. All the patients received 10 microinjections (intramuscularly and perinervously) of 0.1 ml CL daily during 5 days. Clinical study was combined with device estimation of cognitive functions and communicative skills. CL therapy resulted in improvement of cognitive functions (expressive and receptive speech, fine motoring, playing). Positive effects were revealed in all the patients with Asperger's syndrome and in 89% of the patients with childhood autism. Any negative effects were not found. With regard to cognitive functions development, therapeutic efficacy proved to be more pronounced in the patients with Asperger's syndrome as compared to childhood autistic group (p < 0.005).
Subject(s)
Amino Acids/therapeutic use , Asperger Syndrome/drug therapy , Autistic Disorder/drug therapy , Cognition/drug effects , Nootropic Agents/therapeutic use , Asperger Syndrome/physiopathology , Autistic Disorder/physiopathology , Child , Child, Preschool , Cognition/physiology , Female , Humans , Male , Treatment OutcomeABSTRACT
The paper outlines the computer-aided testing diagnostic systems used at the Moscow Therapeutical Research Center for Prevention and Treatment of Mental and Nervous Disability. They are based on the complex factorial approach. This approach takes into account the developmental vectors in a child. These include motor, perceptive, intellectual, and communicative vectors. The complex approach makes it possible not only to establish the actual level of development of basic higher mental functions, but to determine treatment-induced developmental changes and prognosis.
Subject(s)
Brain Diseases/diagnosis , Developmental Disabilities/diagnosis , Diagnosis, Computer-Assisted , Age Factors , Child Development , Child, Preschool , Developmental Disabilities/psychology , Diagnosis, Differential , Humans , Infant , Mother-Child Relations , Neuropsychological Tests , NeuropsychologyABSTRACT
105 children with cerebral paralysis at the age under 3 years were examined. CNS damages in children of early age with disneuroontogenesis may be divided into 4 degrees of severity. This enables to estimate objectively both the patients' state and the results of their therapy in the groups with the same degree of severity of CNS damage. High efficiency of the complex method of metameric stimulation of the development of static-motor and psychospeech functions allows to recommend this method for treatment of children with cerebral paralysis. Application of this method in children of early age with disorders of neurologic development in some cases prevents neurologic disability.
Subject(s)
Cerebral Palsy/complications , Cognition Disorders/etiology , Movement Disorders/etiology , Perceptual Disorders/etiology , Speech Disorders/etiology , Child , Child, Preschool , Cognition Disorders/diagnosis , Humans , Movement Disorders/diagnosis , Perceptual Disorders/diagnosis , Severity of Illness Index , Speech Disorders/diagnosisABSTRACT
The paper reports the case of sibs, brother and sister, with Martin-Bell's syndrome confirmed cytogenetically. Mental retardation and autism were the main phenomena in the clinical picture. Positive effect was achieved by means of Skvortsov--Osipenko method (metameric injection of cerebral hydrolysates' preparations, stimulation of visual, acoustic and proprioceptive analyzers). A decline of the signs of intellectual retardation and autism were observed in both children.
Subject(s)
Autistic Disorder/therapy , Intellectual Disability/therapy , Acoustic Stimulation , Amino Acids/administration & dosage , Animals , Autistic Disorder/complications , Autistic Disorder/diagnosis , Brain , Child , Child, Preschool , Evaluation Studies as Topic , Female , Humans , Intellectual Disability/complications , Intellectual Disability/diagnosis , Magnetic Resonance Imaging , Male , Nootropic Agents/administration & dosage , Photic Stimulation , Proprioception , Syndrome , Time FactorsSubject(s)
Brain Chemistry , Brain , Protein Biosynthesis , Tissue Extracts/pharmacology , Animals , Brain/drug effects , Brain/metabolism , Brain Stem/chemistry , Cattle , Cells, Cultured , Cerebellum/chemistry , Cerebellum/drug effects , Cerebral Cortex/chemistry , Hydrolysis , Kidney/drug effects , Kidney/metabolism , Liver/drug effects , Liver/metabolism , Male , Mice , Neuroglia/cytology , Neuroglia/drug effects , Neuroglia/metabolism , Spleen/drug effects , Spleen/metabolismABSTRACT
The paper describes devices used to examine motor functions in preschool children, methods of examinations and presents their results. Instrumental indices of the development of large and small motility in preschool children and objective criteria for the efficiency of stimulant therapy are proposed. It is shown that the devices for examination of motor functions may be successfully used to train coordination functions of a child and to correct static motor and ocular motor performance.
Subject(s)
Ataxia/diagnosis , Cerebral Palsy/diagnosis , Motor Activity , Physical Examination/instrumentation , Age Factors , Ataxia/physiopathology , Ataxia/therapy , Cerebral Palsy/physiopathology , Cerebral Palsy/therapy , Child , Child, Preschool , Eye Movements , Female , Humans , Male , Physical Examination/methods , Posture , SoftwareABSTRACT
Computed tomography (CT) morphometry of the brain in preschool children in the critical period reflects the dynamic process of the brain formation, multidirectional laterality of the hemispheres. Close relationships between neuropsychological and CT results demonstrate general tendency of the neuro-ontogenetic process comprising reciprocal interaction of functional activity and structural arrangement of the brain compartments.
Subject(s)
Attention Deficit Disorder with Hyperactivity/diagnostic imaging , Brain/diagnostic imaging , Tomography, X-Ray Computed , Aging/pathology , Attention Deficit Disorder with Hyperactivity/pathology , Attention Deficit Disorder with Hyperactivity/psychology , Brain/pathology , Child , Child, Preschool , Dominance, Cerebral , Functional Laterality , Humans , NeuropsychologySubject(s)
Autistic Disorder/diagnosis , Rett Syndrome/diagnosis , Adolescent , Brain/metabolism , Child , Child, Preschool , Diagnosis, Differential , Female , Glucose/metabolism , Humans , Infant , Neuropeptides/deficiency , Neuropeptides/metabolism , Rett Syndrome/etiology , Virus Diseases/complicationsABSTRACT
A case of Raynaud's disease in a 2-year-old child seen by the authors for 1.5 yr. is described. The paper treats of the basic reported data on the pathogenesis, clinical picture and treatment of Raynaud's phenomenon and disease; the child's disease history and the main clinical manifestations are described as are the results of examinations. The case is characterized by successful counteracting the main clinical manifestations of Raynaud's phenomenon by the local metameric application of cerebrolysin (neuromeric, scleromeric puncturing) employed by the authors for the first time for the disease treatment. Interpretation of the effect obtained is briefed.
Subject(s)
Amino Acids/administration & dosage , Fingers/blood supply , Raynaud Disease/drug therapy , Vasodilator Agents/administration & dosage , Arteries/diagnostic imaging , Arteries/drug effects , Arteries/physiopathology , Child, Preschool , Humans , Injections, Intra-Arterial , Male , Raynaud Disease/diagnostic imaging , Raynaud Disease/physiopathology , Regional Blood Flow , UltrasonographyABSTRACT
The authors analyze the current methods of the diagnosis and prediction of perinatal CNS lesions in neonates and infants. Emphasize the importance of revealing non-gross, even minimum manifestations. Provide evidence for the diagnostic and prognostic information content of the elaborated dynamic approach to the assessment of the neonates' neurological status. Relate the technique of an electroneuromyographic examination of neonates of the first hours and days of life. Analyze the results of echo-encephaloscopic examination of neonates. Distinguish new biochemical markers of perinatal CNS lesions.
Subject(s)
Brain Diseases/diagnosis , Child Health Services/organization & administration , Biomarkers/blood , Brain Diseases/blood , Brain Diseases/congenital , Child, Preschool , Echoencephalography , Humans , Infant , Infant, Newborn , Magnetic Resonance Spectroscopy , Sialic Acids/bloodABSTRACT
The phenomenon of a "local punch" of tissues in the zone of nano- or picosecond impulses of neodymium: YAG-laser radiation focusing allows to increase energy in the pulse by one order as compared with traditionally used energy. At this, in order to achieve the initial effect it becomes possible to reduce the number of shots by two orders and thus to increase the spot of radiation. The summary energy of action absorbed in the eye remains the same and that's why the number of complications doesn't increase. The widening of possibilities to choose a laser source for micro- and macroperforations allows, when prescribing the treatment, to more reliably consider clinical peculiarities in each concrete case.
Subject(s)
Iris/surgery , Laser Therapy/methods , Pupil , Cataract Extraction/instrumentation , Cataract Extraction/methods , Equipment Design , Humans , Iris/injuries , Laser Therapy/instrumentation , Lens, Crystalline/injuries , Visual AcuityABSTRACT
In 121 children with perinatal CNS damage a combined therapy was performed including, besides routine drug treatment, imitation stimulation of age-matched posture-++-tonic attitudes and motor skills, metameric reflexotherapy aimed at the CNS region lesioned, magnetotherapy, electric laser puncture targeted at correction of dysfunctioning brain structures. Treatment efficiency was controlled by the brain "development profile" derived from formalized neurological and neuropsychological investigations, and electroneuromyography. The efficiency of the therapy was considerably decreased by the 3rd semester of life.
Subject(s)
Cerebral Palsy/complications , Psychomotor Disorders/therapy , Speech Disorders/therapy , Cerebral Palsy/physiopathology , Combined Modality Therapy , Electroacupuncture , Humans , Infant , Infant, Newborn , Laser Therapy , Motor Activity/physiology , Psychomotor Disorders/etiology , Psychomotor Disorders/physiopathology , Speech/physiology , Speech Disorders/etiology , Speech Disorders/physiopathologySubject(s)
Nervous System Diseases/diagnosis , Child , Child, Preschool , Humans , Infant , Infant, Newborn , Methods , Nervous System Diseases/therapyABSTRACT
A total of 124 preschool children aged 5 to 6 years attending kindergartens or placed into children's homes were subjected to neurologic and neuropsychologic examinations. The alterations revealed were inconclusive and of various kinds. On the one hand, they were characterized by an increase by 5 to 6 years of age in the frequency of the minimal signs of pyramidal and cerebellar failure and of the phenomenon of mirror movements and writing. On the other hand, those alterations were marked by improved readings of the higher psychic functions. On electroneuromyography the interage differences were confirmed by a decrease of the motosensory ratio in children aged 5 years as compared to those aged 4 and 6 years. The alterations described were given the name of the "functional turn" which as the most important stage in the critical preschool period includes both progressive evolutionary jump and functional unbalance associated with rearrangement of the functions of the body or a system.
Subject(s)
Child Development , Child, Preschool , Growth , Child , Humans , Neurologic Examination , Neuropsychological TestsABSTRACT
Neurological and neuropsychological examination of 60 children (aged 5-6 years) from day-care centers has made it possible to identify a group of children at risk in relation to school disadaptation (31.7%). Minimum pyramidal, extrapyramidal, or mixed insufficiency was observed in 28.3% of children. An analysis of the severity of disorders of higher mental functions in "high risk" children has helped differentiate three forms of minimum cerebral dysfunction. The authors have outlined the perspectives of the corrective purposeful therapy in each of the forms.
Subject(s)
Ambulatory Care/methods , Attention Deficit Disorder with Hyperactivity/epidemiology , Child Health Services , Mass Screening/methods , Psychomotor Disorders/epidemiology , Adaptation, Physiological , Attention Deficit Disorder with Hyperactivity/diagnosis , Child, Preschool , Higher Nervous Activity , Humans , Moscow , Neurologic Examination , Neuropsychological Tests , Psychomotor Disorders/diagnosis , Risk Factors , Urban PopulationSubject(s)
Brain Diseases/therapy , Brain/abnormalities , Child Health Services/organization & administration , Adult , Age Factors , Birth Injuries/therapy , Brain Damage, Chronic/etiology , Brain Damage, Chronic/therapy , Brain Injuries/etiology , Brain Injuries/therapy , Female , Humans , Infant , Infant, Newborn , Male , Pregnancy , RussiaABSTRACT
The authors conducted a neurologic, electromyographic and electroneuromyographic investigation in 64 preschool children in a children's home. Subtle static-motor deficit was detected in 79.7% of the children. Major clinico-electroneuromyographic differences were found in 5- vs 6-year old children that were regarded as a functional shift reflecting both the new practical skills formation and a temporary imbalance in motor functional mechanisms at all integration levels.
Subject(s)
Psychomotor Disorders/diagnosis , Basal Ganglia Diseases/diagnosis , Basal Ganglia Diseases/physiopathology , Child , Child, Preschool , Electromyography , Humans , Neurologic Examination , Neuromuscular Diseases/diagnosis , Neuromuscular Diseases/physiopathology , Psychomotor Disorders/physiopathology , Psychomotor Performance/physiologyABSTRACT
The authors analyse the results of NMR tomography of 48 children (5 mos.-14 years) with various diseases of the CNS system mainly connected with pre and perinatal lesions. High percentage of various disorders in the formation of the brain and spinal cord as the main neurological pathology, is noted. Problems of pathogenesis of atrophic changes of the brain and pathology of corpus callosum are discussed.
