Surgical Excision of Localized Gingival Overgrowth Using Laser: A Case Report.

Gingival overgrowth, localized or generalized, is one of the leading causes of poor maintenance of oral hygiene. Excision of growth using laser should be the choice of treatment because laser helps maintain a blood-free surgical site during treatment and provides more patient comfort during and after the procedure. Lasers are commonly employed in many different applications, including scaling, root planning, cavity preparation, and excision of soft tissue growths in surgery. Laser therapy offers numerous benefits over traditional methods of treatment. These benefits have led to the growing use of lasers as dental treatment options in a variety of dental fields. In this case report, we are presenting a case of excision of localized gingival growth using a laser. Postoperative healing and maintenance of oral health were satisfied after laser surgery.

Correlation of Gastrointestinal Symptoms at Initial Presentation with Clinical Outcomes in Hospitalized COVID-19 Patients: Results from a Large Health System in the Southern USA.

BACKGROUND: We aimed to understand the association of gastrointestinal (GI) symptoms at initial presentation with clinical outcomes during COVID-19 hospitalization. METHODS: This retrospective, multicenter cohort study included consecutive hospitalized COVID-19 patients from a single, large health system. The presence of GI symptoms was assessed at initial presentation and included one or more of the following: nausea, vomiting, diarrhea and abdominal pain. Patients were divided into three cohorts: Only GI symptoms, GI and non-GI symptoms and only non-GI symptoms. The primary outcome was association of GI symptoms with mortality. Secondary outcomes included prevalence of GI symptoms and survival analysis. RESULTS: A total of 1672 COVID-19 patients were hospitalized (mean age: 63 ± 15.8 years, females: 50.4%) in our system during the study period. 40.7% patients had at least one GI symptom (diarrhea in 28.3%, nausea/vomiting in 23%, and abdominal pain in 8.8% patients), and 2.6% patients had only GI symptoms at initial presentation. Patients presenting with GI symptoms (with or without non-GI symptoms) had a lower mortality rate compared to patients presenting with only non-GI symptoms (20% vs. 26%; p < 0.05). The time from hospitalization to being discharged was less for patients presenting with only GI symptoms (7.4 days vs. > 9 days, p < 0.0014). After adjusting for other factors, the presence of GI symptoms was not associated with mortality (p > 0.05). CONCLUSION: Among a hospitalized COVID-19 positive Southern US population, 41% patients presented with either diarrhea, nausea, vomiting or abdominal pain initially. The presence of GI symptoms has no association with in-hospital all-cause mortality.

Central retinal vein occlusion with COVID-19 infection as the presumptive etiology.

Thromboembolic phenomenon related to Coronavirus disease 2019 (COVID-19) has been well documented in literature; however, reported ocular manifestations of COVID-19 are limited to vision sparing ocular conditions like conjunctivitis. We report a case of a 17-year-old female who presented to us with central retinal vein occlusion with proven recent past COVID-19 infection as presumed etiology which was not known to her at the time of presentation.

DEVELOPMENT OF AN ALGORITHM TO ESTIMATE EYE LENS DOSE IN TERMS OF OPERATIONAL QUANTITY Hp(3) USING HEAD TLD BADGE.

In view of the recommendations of International Commission on Radiological Protection for reduction of the occupational annual dose limit for eye lens from 150 mSv to 20 mSv/y, questions have been raised on the adequacy of monitoring for the quantities Hp(10) and Hp(0.07). As an immediate requirement, in the present situation, where there is no exclusive eye lens dosemeter in India, the existing chest TLD badge was modified to be used as head badge (head dosemeter) by including a strap to enable wearing on the forehead. In order to estimate the eye lens dose in terms of the operational quantity Hp(3), the prevalent algorithm of chest badge was also modified. The modified algorithm was applied to estimate Hp(3) for dosemeters irradiated to various beta and photon radiations including mixtures. The Q values (estimated/delivered dose equivalent) were found to be within ±20% for most of the photon beams.

BETA DOSE EVALUATION ALGORITHM FOR CaSO4:Dy BYSED TLD BADGE USED IN COUNTRYWIDE PERSONNEL MONITORING PROGRAMME IN INDIA.

The prevalent algorithm for the estimation of beta dose, which in turn is used for estimation of skin dose for exposures involving beta radiations was observed to significantly overestimate the dose in individual monitoring based on CaSO4:Dy TLD badge in India. A new algorithm has been developed by estimating the correction factor from the response of dosemeter to different beta sources at various angles of incidence. The correction factor was observed to vary linearly with the ratio of the responses of dosemeter element without filter (D3) and dosemeter element under Perspex filter (D2). The correction factor determined using the ratio of D3 and D2 was applied to the response (D3) of dosemeter element without filter for estimation of beta dose. Protocol for identification of beta in the mixed gamma beta fields was defined such that it resulted in nearly same correction factor for given beta source in both gamma beta mixed fields and pure beta fields. The beta dose evaluation algorithm has provided the beta dose estimation within the required accuracy for >90% cases obtained from national quality assurance test data from different laboratories.

Impact of periodontal status on oral health-related quality of life among police personnel in Virajpet, India.

AIM: The aim of the present study was to determine the association between oral health-related quality of life (OHRQoL) and periodontal status among police personnel in Virajpet, India. METHODS: Police personnel were randomly selected from the 296 police staff working in Virajpet, India. A self-administered questionnaire was used to collect information on their demographics and dental visit behavior, and to determine their OHRQoL. The community periodontal index (CPI) and loss of attachment were used to assess periodontal status. RESULTS: All 72 invited participants joined this study. The majority (n = 133) had good OHRQoL. For those with a good OHRQoL, 74 had CPI = 0, 25 had CPI = 1, 20 had CPI = 2, and 14 had CPI ≥ 3. For those who had an average or poor OHRQoL (n = 37), 19 had CPI = 0, one had CPI = 1, eight had CPI = 2, and nine had CPI ≥ 3. There was a statistically-significant association between OHRQoL and CPI (P < 0.003). Most participants with good OHRQoL (127/133), but only less than half with an average or poor OHRQoL (22/37), had no loss of periodontal attachment (P < 0.0001). CONCLUSION: In the present study, there was an association between OHRQoL and periodontal status among police personnel in Virajpet, Coorg.

Glycosyl alkoxythioimidates as building blocks for glycosylation: a reactivity study.

Structural modifications of the leaving group of S-glycosyl O-methyl phenylcarbamothioates (SNea) involving change of substituents that express different electronic effects led to a better understanding of how the reactivity of these glycosyl donors can be modified by changing the structure of their leaving groups. Mechanistic studies involving the isolation of departed aglycones were indicative of the direct activation of both p-methoxy-SNea and p-nitro-SNea leaving groups via the anomeric sulfur rather than the remote nitrogen atom. The presence of an electron donating substituent (p-methoxy) has a strong effect on the nucleophilicity of the sulfur atom that becomes more susceptible toward the attack of thiophilic reagents, in particular. This key observation allowed to differentiate the reactivity levels of p-methoxy-SNea versus p-nitro-SNea and even unmodified SNea leaving groups. The reactivity difference observed in the series of SNea leaving groups is sufficient to be exploited in expeditious oligosaccharide synthesis via selective activation strategies.

Development of a technique for improving coefficient of variation of CaSO4:Dy teflon-based TLD personnel monitoring system in low-dose region.

In view of the importance of zero-dose background (null signal) in influencing the coefficient of variation in low-dose region, a technique for the estimation of the same from composite (gross) signal is developed for CaSO4:Dy-based personnel monitoring system being used in India. The technique is based on simple analysis of glow curves (GCs) of unexposed and exposed dosemeters, evolution of trend/model for the zero-dose curves, generation of simulation protocol for individual zero-dose curves, establishment of characteristics of GCs of exposed dosemeters and finally preparation of an algorithm to segregate the components from composite signal. The technique offers the separation of real-time background and gives superior results over other method of approximation of the background. The results also prove efficiency of the empirical trending and simulation protocol of background GCs. The proposed technique can be implemented in routine monitoring without any extra man hours and reader time.

Inhibitors of pancreatic lipase: state of the art and clinical perspectives.

Obesity is a disorder of lipid metabolism and continues to be a global problem, ranking fifth for deaths worldwide. It also leads to diabetes, cardiovascular disorders, musculoskeletal disorders and some types of cancer. Obesity is regarded as the output of a long-term imbalance between energy intake and energy expenditure. Digestion and absorption of dietary lipids by pancreatic lipase, a major source of excess calorie intake, can be targeted for development of anti-obesity agents. Being the major factor of concern, food materials and edible plants are most widely studied for the anti-obesity activity, so that they can be incorporated in the routine diet. In this review, an attempt was made to present a current scenario of the bioactive compounds from plant and microbial origin that have been investigated for their pancreatic lipase inhibition. Compounds belonging to various classes of natural products such as alkaloids, carotenoids, glycosides, polyphenols, polysaccharides, saponins and terpenoids are well studied while lipophilic compounds from microbial sources are the most active against the pancreatic lipase. Few studies on the synthetic analogues, structurally similar to the triglycerides have been described in the review. Despite of tremendous research on the finding of potential pancreatic lipase inhibitor, very few compounds have entered the clinical studies and no new molecule after orlistat has been marketed. Along with HTS based screening, detailed structure-activity relationship studies on semi-synthetic and synthetic derivatives might also provide a direction for the development of potential lead(s) or pharmacophore for pancreatic lipase inhibition in order to treat and/or prevent obesity and related disorders.

A method of identification of abnormal glow curves in individual monitoring using CaSO4:Dy teflon TLD and hot gas reader.

In the present study, a method of identifying abnormal glow curves to electronically screen the glow curves of TL readout is presented. The method is based on the fact that the shape of an abnormal glow curve differs from the shape of a normal one. A few criteria for defining the normal shape of glow curves are arrived at by analysing the glow curves of dosemeters exposed to various doses in laboratory conditions and read at different elapsed time post irradiation. About 300 glow curves of dosemeters used for monthly monitoring were analysed as per these criteria and the effectiveness of the method is observed for total counts as low as 150 µSv equivalent.

Glycosyl alkoxythioimidates as complementary building blocks for chemical glycosylation.

It is reported that S-glycosyl O-methyl phenylcarbamothioates (SNea carbamothioates) have a fully orthogonal character in comparison to S-benzoxazolyl (SBox) glycosides. This complete orthogonality was revealed by performing competitive glycosylation experiments in the presence of various promoters. The results obtained indicate that SNea carbamothioates have a very similar reactivity profile to that of glycosyl thiocyanates, yet are significantly more stable and tolerate selected protecting group manipulations. These features make the SNea carbamothioates new promising building blocks for further utilization in oligosaccharide synthesis.

Study of minimum detection limit of TLD personnel monitoring system in India.

Personnel monitoring of radiation workers in India is carried out using a thermoluminescence dosemeter (TLD) system based on CaSO(4):Dy Teflon TLD disc. The dose due to occupational exposure for a majority of radiation workers is very small and hence is reported as zero. In view of this the detection of low levels of occupational dose over and above a variable background assumes great importance. The present values of reporting levels are based on the standard deviations of annealed dosemeters and therefore are fixed irrespective of period of use and background radiation levels. The validity of these levels is investigated under laboratory conditions. The laboratory values of standard deviations cannot be used as an indication of the imprecision that occurs during service. Therefore, the validity of the reporting levels is also investigated for control dosemeters used in routine service.

Development of an algorithm for evaluating personal doses due to photon fields in terms of operational quantities for TLD badge system in India.

In order to evaluate and report the personal doses in terms of personal dose equivalent, the performance of the CaSO(4):Dy based thermoluminescence dosemeter (TLD) badge used for countrywide personnel monitoring in India is investigated using monoenergetic and narrow spectrum radiation qualities equivalent to those given in ISO standards. Algorithms suitable for evaluating H(p)(10) and H(p)(0.07) within +/- 30 % are developed from the responses of dosemeter elements/discs under different filters for normal as well as angular irradiation conditions using these beams. The algorithm is tested for TLD badges irradiated to mixtures of low- and high-energy ((137)Cs) beams in various proportions. The paper concludes with the results of test of algorithm by evaluation of badges used in the IAEA/RCA intercomparison studies and discussion on inherent limitations.

STICS: surface-tethered iterative carbohydrate synthesis.

A new surface-tethered iterative carbohydrate synthesis (STICS) technology is presented in which a surface functionalized 'stick' made of chemically stable high surface area porous gold allows one to perform cost efficient and simple synthesis of oligosaccharide chains; at the end of the synthesis, the oligosaccharide can be cleaved off and the stick reused for subsequent syntheses.