ABSTRACT
The aim of the present study was to investigate the survival of individuals with squamous cell carcinoma of the lower oral cavity who underwent surgical treatment and experienced recurrence, considering the site of the recurrent disease. A retrospective longitudinal study was conducted, comparing the survival rates of patients with and without recurrence and considering the site of recurrence (local, regional, distant). Statistical analysis was performed with SPSS and a p-value ≤ 0.05 was considered significant. The sample comprised 150 patients, 59 (39.3%) of whom experienced recurrence. Local recurrence occurred in 35 patients (23.4%), regional recurrence in 17 (11.3%), and distant recurrence in seven (4.6%). The average survival of participants with local, regional, and distant recurrence was 12, five, and two months, respectively. Patients with recurrent disease had worse survival than those who did not (P < 0.001). Patients with local recurrence had better survival than those with regional/distant recurrence (P = 0.011). All patients with regional and distant recurrence had deceased by the last follow-up. In conclusion, patients with local recurrence of squamous cell carcinoma of the lower oral cavity treated by surgery have a better survival rate than those with regional and distant recurrence. Local recurrence poses the possibility of curative salvage therapy.
Subject(s)
Dermatofibrosarcoma/surgery , Facial Neoplasms/surgery , Plastic Surgery Procedures/methods , Skin Neoplasms/surgery , Dermatofibrosarcoma/rehabilitation , Facial Neoplasms/rehabilitation , Female , Follow-Up Studies , Graft Survival , Humans , Microsurgery/methods , Middle Aged , Muscle, Skeletal/transplantation , Neoplasm Invasiveness , Neoplasm Recurrence, Local/rehabilitation , Neoplasm Recurrence, Local/surgery , Nose Neoplasms/rehabilitation , Nose Neoplasms/surgery , Orbit Evisceration/rehabilitation , Prostheses and Implants , Radiotherapy, Adjuvant , Rectus Abdominis/transplantation , Skin Neoplasms/rehabilitation , Skin Transplantation/methods , Surgical Flaps , Surgical Wound Infection/etiologyABSTRACT
Histoplasma capsulatum infection involving the larynx is a rare manifestation, especially in immunocompetent individuals and a high index of suspicion is needed to establish the diagnosis correctly. We report a case of a 50-year-old Brazilian man who presented with progressive hoarseness and throat pain for 4 months. Laryngoscopy showed a supraglottic vegetant lesion, and the biopsies chronic granulomatous inflammation without any specific agent. A second laryngoscopy with biopsies was performed and after 17 days of incubation in specific medium, H. capsulatum was isolated. The patient was successfully treated with amphotericin B.
