[The specific features of regenerative processes of hip and shin fractures in patients with superinvasion opisthorchiasis].

Opisthorchis superinvasion retains the natural manifestations of reparative regeneration of skeletal tissues, but activates proliferation stages and increases the promoter manifestations of histogenesis. Irrespective of a surgical option, the rate of infestation, and the place of residence, reparative regeneration of shaft fractures of the shin and hip occurs significantly more rapidly in patients with superinvasion opisthorchiasis than in those without the latter. In superinvasion opisthorchiasis, bone is restituted by early callus formation and accelerated regenerate mineralization.

[Provisionality phenomenon in the histo- organo- and systemogenesis].

This review summarizes the results of the study of the provisionality phenomenon in the development of the organs of the urinary system (mesonephros, metanephros) in viviparous (human, rat) and oviparous (bird) amniotes, human organs of mixed origin (pituitary, ovary, stomodeum) reparative regeneration of supporting tissues (in humans and Syrian hamster), morphogenesis of primary hepatic cancer developing against the background of superinvasive opisthorchiasis. It is shown that during the development of tissues and organs, the stages of provisional and definitive histo- and organogenesis could be determined; saltatory mechanism is typical for embryonic organogenesis (formation of cartilaginous skeletal primordia, meso- and metanephrons) and foci of oncogenesis. Transformation zones of the type of tissue organization in the epithelium are located in the areas of contacts of the derivatives of different embryonic primordia. Mechanism of transformation of the epithelial layer of stomodeum and Rathke's pouch is provided by local activation of apoptosis and by the formation of the epithelial cells of a qualitatively new generation.

Embryonic morphogenesis of the human pituitary.

Light microscopy methods were used to study the main stages in the organogenesis of the pituitary in human embryos at Carnegie stages (CS) 12-23. Rathke's pouch (RP) was shown to form as a traction fold over whole width of the roof of the stomodeum in embryos at CS 12 due to a flexure of the neural tube with which the epithelium had a tight anatomical relationship (the attached part of the anterior wall of the RP) in the median plane of the embryo. The rudiment of the hypothalamic infundibulum and neurohypophysis formed at CS 15, as a thickening of the posterior wall of the diencephalon. Transorientation of the positions of brain components, including the rudiment of the hypophysis, occurred at CS 20-23. The attached part of the anterior wall of the RP then formed the pars intermedia and pars tuberalis of the anterior lobe, while the epithelium of the orifice of the RP and its posterior wall formed the pars distalis. From CS 20 to 23, the RP epithelium formed the structural-functional units of the adenohypophysis, i.e., the epithelial cords, by invagination.

[Human pituitary embryonic morphogenesis].

Basic stages of pituitary gland organogenesis were studied using the methods of light microscopy in human embryos at Carnegie stages (CS) 12-23 (25-57 postovulatory days). It is shown that Rathke's pouch (RP) is formed like a traction fold along the whole width of the stomodeum roof in embryos at CS 12 as a result of a neural tube bend, to which the epithelium is closely connected anatomically (attached part of RP front wall) in the middle plane of the embryo. At CS 15 the primordia of hypothalamic infundibulum and of neurohypophysis are formed as a thickening of diencephalic posterior wall. At CS 20-23 transorientation of brain components, including hypophyseal primordium, takes place. After that the attached part of RP front wall forms pars intermedia and pars tuberalis of the pituitary, and the epithelium of RP orifice and that of its posterior wall forms pars distalis. During CS 20-23, structural-functional units of adenohypophysis--epithelial cords--are formed due to invagination of RP epithelium.

[Role of provisionality principle in realization of phylembryogeneses].

The analysis of histogenesis of skeletogenic tissues and of organogenesis of the mesonephros and metanephros in higher mammalian animals and man, is presented. The new conception of provisionality is formulated, according to which embryonic primordium and/or its derivatives possess a determined capacity to form, on its course to definitive state, temporary structures (tissues or organs), which fulfil the vital functions in the developing organism and modeling the mechanisms of development and formation of structural and functional units or the whole organ at the level of definitive morphological substrate. Provisionality is regarded as the universal principle in realization of of phylembryogeneses.

[Effects of vitamins A, E, C and P on intensity of blood coagulation in experimental animals]. / Vlianie vitaminov A, E, C i P na intensivnost' vnutrisosudistogo svertyvaniia krovi v éksperimente.

In experiment on white rats it was shown that preventive 12-day administration of vitamins A, E, C, P decreases the death rate of animals with exogenous thromboplastinemia and reduces hemocoagulative changes, microcirculation disorders, destructive changes of functionally active elements of inner organs. The protective effect of the above vitamins combination in thromboplastinemia is promoted by hypoactivity of platelet aggregation, by low thromboplastic activity of erythrocytes, by limited destruction of vascular endothelium.

[Effect of an Opisthorchis infestation on implantation growth of the liver epithelium]. / Vliianie opistorkhoznoi invazii na implantatsionnyi rost épiteliia pecheni.

The features of proliferation and differentiation of the liver ductular epithelium from animals infected with opisthorchis were specified in experimental implantation growth. They manifested themselves in disorders of the mitotic regimen and intercellular interactions, in atypical proliferations and primary glandular metamorphism of regenerating cells.

[Implantation growth of nephrogenic tissue and the epithelium of renal nephron tubules in cultures within the body]. / Implantatsionnyi rost nefrogennoi tkani i épiteliia kanal'tsev nefrona pochki v kul'turakh v organizme.

Comparative study of the implantation growth of nephrogenic tissue in a 17-day-old embryo of rats and the epithelium of nephrons in the one-month-old animals showed that nephrogenic tissue in the implants manifested regularities characteristic of its histogenesis. The nephron epithelium of the one-month-old animals is characterized by tissue growth and formation of atypical organ structures, this indicating its capacity for tissue and organotypical differentiation. A conclusion was drawn on wide range of the reactive and plastic properties of a nephron epithelium, as well as on the existence of its organotypical differentiation.