The effects of home-based progressive resistance training in chronic kidney disease patients.

INTRODUCTION: Faced with lockdowns, it was mandatory the development of supervised home-based RT protocols to keep patients with chronic kidney disease engaged in programs. Nonetheless, there is a lack of scientific literature regarding its effects on patients. PURPOSE: To investigate the effects of a supervised home-based progressive resistance training program on functional performance, bone mineral density, renal function, endothelial health, inflammation, glycemic homeostasis, metabolism, redox balance, and the modulation of exerkines in patients with CKD in stage 2. METHODS: Patients (n = 31) were randomized and allocated into the control group (CTL; n = 15; 58.07 ± 5.22 yrs) or resistance training group (RT; n = 16; 57.94 ± 2.74 yrs). RT group performed 22 weeks of supervised progressive home-based resistance exercises. Bone mineral density, anthropometric measurements, and functional performance were assessed. Venous blood samples were collected at baseline and after the intervention for the analysis of markers of renal function, endothelial health, inflammation, glycemic homeostasis, metabolism, and redox balance. RESULTS: Twenty-two weeks of home-based RT were effective in improving (P < 0.05) functional performance, bone mineral density, uremic profile, ADMA, inflammatory markers, the Klotho-FGF23 axis, glycemic homeostasis markers, and exerkines. These improvements were accompanied by higher concentrations of exerkines and anti-inflammatory cytokines. RT group displayed a decrease in cases of osteopenia after the intervention (RT: 50 % vs. CTL: 86.7 %; X2 = 4.763; P = 0.029). CONCLUSION: Results provide new evidence that supervised home-based progressive RT may be a relevant intervention to attenuate the progression of CKD and improve functional capacity, bone mineral density, and the immunometabolic profile. These improvements are associated with positive modulation of several exerkines.

Master athletes have longer telomeres than age-matched non-athletes. A systematic review, meta-analysis and discussion of possible mechanisms.

The aim of this systematic review and meta-analysis was 1) to assess whether master athletes have longer telomeres than age-matched non-athletes and 2) discuss possible underlying mechanisms underlying telomere length preservation in master athletes. A literature search was performed in PubMed, Web of Science, Scopus and SPORTDiscus up to August 2020. Only original articles published in peer-reviewed journals that compared telomere length between master athletes and aged-matched non-athletes were included. Eleven studies fulfilled eligibility criteria and were included in the final analysis. Overall, 240 master athletes (51.9±7.5 years) and 209 age-matched non-athletes (50.1±9.1 years) were analyzed. Master athletes had been participating in high-level competitions for approximately 16.6 years. Pooled analyses revealed that master athletes had longer telomeres than aged-matched non-athletes (SMD=0.89; 95% CI=0.45 to 1.33; p<0.001). Master athletes showed lower pro-oxidant damage (SMD=0.59; 95% CI=0.26 to 0.91; p<0.001) and higher antioxidant capacity (SMD=-0.46; 95% CI=-0.89 to -0.03; p=0.04) than age-matched non-athletes. Further, greater telomere length in master athletes is associated with lower oxidative stress and chronic inflammation, and enhanced shelterin protein expression and telomerase activity. In conclusion, 1) master athletes have longer telomeres than age-matched non-athletes, which may be the result of 2) lower levels of oxidative stress and chronic inflammation, and elevated shelterin expression and telomerase activity.

Physiological Responses to Swimming Repetitive "Ice Miles".

ABSTRACT: Knechtle, B, Stjepanovic, M, Knechtle, C, Rosemann, T, Sousa, CV, and Nikolaidis, PT. Physiological responses to swimming repetitive "Ice Miles." J Strength Cond Res 35(2): 487-494, 2021-"Ice Mile" swimming (i.e., 1,608 m in water of below 5° C) is becoming increasingly popular. Since the foundation of the International Ice Swimming Association (IISA) in 2009, official races are held as World Cup Races and World Championships. Ice swimming was a demonstration sport at the 2014 Winter Olympics in Sochi, Russia. This case study aimed to identify core body temperature and selected hematological and biochemical parameters before and after repeated "Ice Miles." An experienced ice swimmer completed 6 consecutive Ice Miles within 2 days. Three Ice Miles adhered to the strict criteria for the definition of Ice Miles, whereas the other 3 were very close (i.e., 5.2, 6.1, and 6.6° C) to the temperature limit. Swimming times, changes in core body temperatures, and selected urinary and hematological parameters were recorded. The athlete showed after each Ice Mile a metabolic acidosis (i.e., an increase in lactate and TCO2; a decrease in base excess and HCO3-) and an increase in blood glucose, cortisol, and creatine kinase concentration. The decrease in pH correlated significantly and negatively with the increase in cortisol level, indicating that this intense exercise causes a metabolic stress. The change in core body temperature between start and finish was negatively associated with metabolic acidosis. The increase in creatine kinase suggests skeletal muscle damages due to shivering after an Ice Mile. For athletes and coaches, swimming in cold water during Ice Miles leads to a metabolic acidosis, which the swimmer tries to compensate with a respiratory response. Considering the increasing popularity of ice swimming, the findings have practical value for swimmers and practitioners (e.g., coaches, exercise physiologists, and physicians) working with them because our results provide a detailed description of acute physiological responses to repeated swimming in cold conditions. These findings are of importance for athletes and coaches for National Championships and World Championships in Ice Swimming following the IISA rules.

The effectiveness of a community-based exercise program on depression symptoms among people living with HIV.

HIV is a worldwide public health issue affecting millions of individuals, and people living with HIV (PLWH) are often affected by depression. Nonetheless, exercise can prevent and treat depression among PLWH. The aim of the present study was to investigate the effect of exercise on depression symptoms in PLWH. Using a prospective single-arm trial, a semi-supervised community-based exercise intervention was offered 3 times/week for 12 weeks to PLWH (n = 52; age: 49 ± 6 years; HIV diagnosis: 19 ± 15 years). Participants were divided into compliant (≥1 exercise session/week) and non-compliant (<1 exercise session/week) groups according to their attendance in the intervention. Depression symptoms were assessed using the Beck Depression Inventory (BDI), and the change in BDI from baseline to post-intervention was assessed with an analysis of covariance, adjusted for demographics. The post-intervention BDI score was significantly lower (p = 0.027) for the compliant group compared to the non-compliant group, and the rate of improvement from moderate/severe symptoms of depression to minimal symptoms of depression was four times greater in the compliant group. In conclusion, a community-based exercise program may be effective in reducing depression symptoms among PLWH.

Influence of Body Fat on Oxidative Stress and Telomere Length of Master Athletes.

ABSTRACT: Aguiar, SS, Rosa, TS, Sousa, CV, Santos, PA, Barbosa, LP, Deus, LA, Rosa, EC, Andrade, RV, and Simões, HG. Influence of body fat on oxidative stress and telomere length of master athletes. J Strength Cond Res 35(6): 1693-1699, 2021-The present investigation analyzed the role of body fat and training history on biological aging of master athletes by comparing and verifying the relationships between markers of adiposity, oxidative balance, and telomere length (TL) in middle-aged runners and untrained individuals. Master athletes (sprinters and endurance runners, n = 21; 51.62 ± 8.19 years) and untrained age-matched controls (n = 11; 45.41 ± 10.34 years) had blood samples collected for biochemical and biomolecular analyzes. Pro-oxidant and antioxidant measures as well as DNA extraction were performed using commercial kits. Relative TL (T/S) was determined in leukocytes through quantitative polymerase chain reaction analyses. Master athletes had lower body fat and longer TL than untrained controls (body fat: 12.21 ± 4.14% vs. 26.03 ± 4.29%; TL: 1.10 ± 0.84 vs. 0.56 ± 0.56 T/S; p < 0.05). Furthermore, master athletes also showed a better oxidative balance than untrained controls (p < 0.05). A negative correlation was observed between TL and body fat (r = -0.471; p = 0.007), and conicity index (r = -0.407; p = 0.021), catalase activity (r = -0.569; p = 0.001), and CAT/TBARS ratio (r = -0.463; p = 0.008) for the whole sample. In conclusion, master athletes have longer TL, better oxidative profile, and lower body fat than untrained individuals. Moreover, for this middle-aged sample, body fat was inversely correlated with both TL and markers of oxidative balance, demonstrating the key role of adiposity in biological aging.

Retraction: A descriptive study on health, training and social aspects of adults that participated in ultra endurance running as youth athletes.

The paper entitled "A descriptive study on health, training and social aspects of adults that participated in ultra endurance running as youth athletes" by Volker Scheer et al, which was published online on September 03 2020, has been withdrawn by the Publisher due to an internal dispute between the authors.

Breaking the athletics world record in the 100 and 400 meters: an alternative method for assessment.

BACKGROUND: The top 10 athletes in the International Association of Athletic Federations in 100-m and 400-m ranking for each sex were assessed for their history of race times before achieving their personal record (PR). The main goal of this study was to create a new method for optimal performance improvement rate assessment for coaches and athletes aiming the World Record. METHODS: The difference between PR ('current' season) and the best race time in the last season was defined as the first season improvement rate (1-SIR), whereas the average improvement rate in the last and preceding seasons was the multi-season improvement rate (M-SIR). 1-SIR and M-SIR were calculated for each athlete. RESULTS: The sex comparison for the 100 m event showed a significant difference in the M-SIR in favor of women. No statistical differences were identified for the 400 m event, with a trivial effect in both 1-SIR and M-SIR. CONCLUSIONS: As a practical applicability, graph plots were designed to help verifying the improvement rate of athletes and to evaluate whether a long-term training strategy induced an acceptable performance improvement or whether some adjustments needed and check within the plots if the improvement rate is within the average of the top-10 athletes of their event.

Hydration Status After an Ironman Triathlon: A Meta-Analysis.

The Ironman is one of the most popular triathlon events in the world. Such a race involves a great number of tactical decisions for a healthy finish and best performance. Dehydration is widely postulated to decrease performance and is known as a cause of dropouts in Ironman. Despite the importance of hydration status after an Ironman triathlon, there is a clear lack of review and especially meta-analysis studies on this topic. Therefore, the objective was to systematically review the literature and carry out a meta-analysis investigating the hydration status after an Ironman triathlon. We conducted a systematic review of the literature up to June 2016 that included the following databases: PubMed, SCOPUS, Science Direct and Web of Science. From the initial 995 references, we included 6 studies in the qualitative analysis and in the meta-analysis. All trials had two measures of hydration status after a full Ironman race. Total body water, blood and urine osmolality, urine specific gravity and sodium plasma concentration were considered as hydration markers. Three investigators independently abstracted data on the study design, sample size, participants' and race characteristics, outcomes, and quantitative data for the meta-analysis. In the pooled analysis, it seems that the Ironman event led to a moderate state of dehydration in comparison to baseline values (SMD 0.494; 95% CI 0.220 to 0.767; p = 0.001). Some evidence of heterogeneity and consistency was also observed: Q = 19.6; I2 = 28.5%; τ2 = 2.39. The results suggest that after the race athletes seem to be hypo-hydrated in comparison to baseline values.

Telomere length and redox balance in master endurance runners: The role of nitric oxide.

Leukocyte telomere length (LTL), a biological marker of aging that is associated with age-related diseases, is longer in master endurance runners (ER) than age-matched controls, but the underlying mechanisms are poorly investigated. The LTL, nitric oxide (NO), and redox balance of ER master runners were analyzed and compared to untrained middle-aged and young adults. We hypothesized that NO and redox balance at baseline would be related to longer LTL in ER athletes. Participants (n = 38) were long-term ER runners (n = 10; 51.6 ±â€¯5.2 yrs.; 28.4 ±â€¯9.4 yrs. of experience) and untrained age-matched (n = 17; 46.6 ±â€¯7.1 yrs) and young controls (n = 11; 21.8 ±â€¯4.0 yrs). Volunteers were assessed for anamnesis, anthropometrics, and blood sampling. Measurements of pro-and anti-oxidant status and DNA extraction were performed using commercial kits. Relative LTL was determined with qPCR analyses (T/S). While the middle-aged controls had shorter LTL than the young group, no difference was observed between ER athletes and young participants. A large effect size between the LTL of ER athletes and middle-aged controls (d = 0.85) was also observed. The ER athletes and untrained young group had better redox balance according to antioxidant/pro-oxidant ratios compared to middle-aged untrained participants, which also had lower values for redox parameters (TEAC/TBARS, SOD/TBARS, and CAT/TBARS; all p < 0.05). Furthermore, the NO level of ER athletes (175.2 ±â€¯31.9 µM) was higher (p < 0.05) than middle-aged controls (67.2 ±â€¯23.3 µM) and young participants (129.2 ±â€¯17.3 µM), with a significant correlation with LTL (r = 0.766; p = 0.02). In conclusion, ER runners have longer LTL than age-matched controls, which in turn may be related to better NO bioavailability and redox balance status.

Sex difference in long-distance open-water swimming races - does nationality play a role?

In open-water swimming events with non-elite swimmers held in the USA, but not in Europe, women were faster than men. We examined the sex difference in elite long-distance open-water swimming races and the role of nationality by investigating 7,468 swimmers competing in 5 km, 10 km and 25 km FINA races held between 2000 and 2016. More men participated in 10 km and 25 km than in 5km races. Men were faster than women and the sex difference was similar in all race distances. Swimming speed was faster for 5km than for 10km, which in turn was faster than 25km. There was a major effect of nationality on swimming speed at 5 km and 10 km, but not at 25km. No dominance of a particular nationality was observed for all race distances. In summary, men were faster than women in all FINA race distances from 5km to 25km but nationality played no role in the sex difference.

Exercise, Telomeres, and Cancer: "The Exercise-Telomere Hypothesis".

Telomeres are genomic complex at the end of chromosomes that protects the DNA and telomere length (TL) is related to several age-related diseases, lifespan, and cancer. On the other hand, cancer is a multifactorial disease that is responsible for reduce the quality of life and kills millions of people every year. Both, shorter TL and cancer are related and could be treated or prevented depending of the lifestyle. In this review we discuss the possible role of exercise in the relationship between shorter telomeres, telomerase activity, and cancer. In summary, there is evidence that exercise leads to less telomere attrition and exercise also may diminish the risk of cancer, these two outcomes are possible intermediated by a reduction in oxidative stress, and chronic inflammation. Although, there is evidence that shorter TL are associated with cancer, the possible mechanisms that one may lead to the other remains to be clarified. We assume that humans under cancer treatment may suffer a great decrease in quality of life, which may increase sedentary behavior and lead to increased telomere attrition. And those humans with already shorter TL likely lived under a poor lifestyle and might have an increased risk to have cancer.