1.
Bioorg Med Chem Lett
; 17(13): 3760-4, 2007 Jul 01.
Article
in English
| MEDLINE
| ID: mdl-17466519
ABSTRACT
Structure-activity relationship on our recently reported triaryl bis-sulfone class of cannabinoid-2 (CB2) receptor selective inverse agonists was explored. Modifications to the methane sulfonamide, substitutions to B and C phenyl rings, and replacements of the C-ring were investigated. A compound with excellent CB2 activity, selectivity for CB2 over CB1, and in vivo plasma levels was identified.