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1.
J Clin Hypertens (Greenwich) ; 21(12): 1784-1794, 2019 12.
Article in English | MEDLINE | ID: mdl-31769171

ABSTRACT

The present paper reports trends in office blood pressure (BP) measurement (OBPM) and ambulatory blood pressure measurement (ABPM) with age in a large multi-center Indian all comers' population visiting primary care physicians. ABPM and OBPM data from 27 472 subjects (aged 51 ± 14 years, males 68.2%, treated 45.5%) were analyzed and compared. Individual differences between OBPM and ABPM patterns were compared for patients according to 10-year age categories. Results showed that systolic (S) BP values started to increase with age from the age of 40, BP variability (SD) increased from the age of 30 years. Diastolic (D) BP values started to decrease from the age of 50 years. Mean OBPM values were higher than daytime ABPM values (all P < .001) in all age-groups. The prevalence of white coat hypertension (WCH) and masked hypertension (MH) was based on OBPM and daytime, 24-hour, and nighttime average BPs together. WCH decreased with age from 15.1% and 12.4% in treated and untreated subjects at the youngest age to 7.2% and 6.9% in the oldest age, respectively. MH prevalence was higher for untreated than for treated subjects but remained similar for all age-groups (range of 18.6%-21.3%). The prevalence of reverse dippers increased with age from the youngest to oldest group with 7.3%-34.2% (P < .001 for trend). Dippers prevalence decreased from 42.5% to 17.9% from the youngest to oldest age-groups, respectively (P < .001 for trend). These findings confirm that BP patterns show clear differences in trends with age, particularly regarding nighttime BP.


Subject(s)
Blood Pressure Determination/instrumentation , Blood Pressure Monitoring, Ambulatory/methods , Blood Pressure/physiology , Hypertension/physiopathology , Adult , Age Factors , Aged , Aged, 80 and over , Antihypertensive Agents/therapeutic use , Biological Variation, Population/physiology , Case-Control Studies , Circadian Rhythm , Diastole/physiology , Female , Humans , Hypertension/diagnosis , Hypertension/drug therapy , India/epidemiology , Male , Masked Hypertension/diagnosis , Masked Hypertension/drug therapy , Masked Hypertension/epidemiology , Middle Aged , Prevalence , Primary Health Care/statistics & numerical data , Systole/physiology , White Coat Hypertension/diagnosis , White Coat Hypertension/drug therapy , White Coat Hypertension/epidemiology
2.
Cardiovasc Revasc Med ; 19(4): 429-432, 2018 06.
Article in English | MEDLINE | ID: mdl-29174500

ABSTRACT

OBJECTIVES: To report long-term results of a novel sirolimus-eluting stent with biodegradable polymer BACKGROUND: Newer generation drug-eluting stents are characterized by thin struts, improved platform design and highly biocompatible polymer carrying the antiproliferative drug. The RapstromTM stent, sharing these features, showed promising outcomes in preclinical models and in a first-in-man trial. METHODS: The present study is a multicenter, non-randomized post-market registry, including patients with de novo coronary artery disease treated with implantation of one or more Rapstrom stents. Primary endpoint of the study was the rate of major adverse cardiac events (MACE) at three-year follow-up. RESULTS: 1073 patients were enrolled, with a high prevalence of diabetes (35%) and acute coronary syndrome at presentation (82%); at three-year follow up, MACE rate was 14.8%, with a low incidence of definite or probable stent thrombosis (0.75%). CONCLUSIONS: These data confirm the good clinical performance of the Rapstrom stent, supporting the concept that the combination of thin struts and biodegradable polymer is associated with positive clinical outcomes.


Subject(s)
Absorbable Implants , Acute Coronary Syndrome/surgery , Cardiovascular Agents/administration & dosage , Coronary Stenosis/surgery , Drug-Eluting Stents , Percutaneous Coronary Intervention/instrumentation , Sirolimus/administration & dosage , Acute Coronary Syndrome/diagnostic imaging , Acute Coronary Syndrome/epidemiology , Cardiovascular Agents/adverse effects , Comorbidity , Coronary Stenosis/diagnostic imaging , Coronary Stenosis/epidemiology , Coronary Thrombosis/epidemiology , Humans , Incidence , Percutaneous Coronary Intervention/adverse effects , Prevalence , Product Surveillance, Postmarketing , Prosthesis Design , Registries , Risk Factors , Sirolimus/adverse effects , Time Factors , Treatment Outcome
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