Bicornuate rudimentary uterine horns with functioning endometrium and complete cervical-vaginal agenesis coexisting with ovarian endometriosis: a case report.

OBJECTIVE: To report a patient with bicornuate rudimentary uterine horns with functioning endometrium and complete cervical-vaginal agenesis coexisting with ovarian endometriosis. DESIGN: Case report. SETTING: University hospital. PATIENT(S): A 37-year-old woman with an extremely rare müllerian anomaly of the uterus and vagina coexisting with ovarian endometriosis. INTERVENTION(S): Resection of the rudimentary uterine horns with bilateral salpingo-oophorectomy. MAIN OUTCOME MEASURE(S): Relief from pelvic pain after the operative procedure. RESULT(S): The definite diagnosis and removal of the müllerian anomaly and endometriosis foci. CONCLUSION(S): Cyclic pelvic pain since the age of 14 was due to cryptomenorrhoea in the presence of the bicornuate rudimentary uterine horns with functioning endometrium and cervical-vaginal agenesis. Ovarian endometriosis developed as a result. In such cases, invasive procedures, such as laparoscopy or laparotomy, should be considered to establish the diagnosis. Removing the functioning rudimentary uterine horns just after menarche should prevent the development of endometriosis and hematometra.

[The role of matrix metalloproteinases in tumor invasion and metastasis]. / Rola metaloproteinaz macierzowych w procesie inwazji nowotworowej i przerzutowaniu.

The complicated process of invasion and metastasis consists of a long series of sequential and interrelated steps. The outcome of the process is dependent on both: the tumour cells and the properties of tissue microenvironments. Many investigators are interested in the influence of extracellular matrix components on that process. Especially matrix metalloproteinases (MMPs)--family of zinc-dependent enzymes, which take part in the coordination of extracellular matrix synthesis and breakdown seems to play crucial role in this process. A positive correlation between different type of MMPs and specific tumors has been demonstrated in many studies. In this article we summarize the current views on the role of MMPs in cancer invasion and metastasis.

[Risk factors and clinical characteristic patients with vulvar cancer]. / Czynniki ryzyka i charakterystyka kliniczna chorych z rakiem sromu w materiale wlasnym.

INTRODUCTION: Vulvar cancer is very rare, accounting for about 3-5% female tract malignancies. Venereal diseases and cigarette smoking have been associated with vulvar cancer. Recently p53 gene mutation and Human Papilloma Virus (HPV) infections have been considered etiologic factors. DESIGN: The main aim of this study was the clinical analysis of patients with vulvar cancer treated in II Gynaecology Department of Medical University in Wroclaw. MATERIAL AND METHODS: We analyzed 25 women with vulvar cancer treated in our center. We focused on: choise of treatment, postoperative complications, p53 gene mutation, survival and recurrence of the disease. p53 gene mutations were detected using immunohistochemical methods with monoclonal Novocastra antibody (DO1). RESULTS: The youngest patient was 49 years old and the oldest 79 (median 70), 5 patients were younger than 60 (24%). 72% patients had overweight and 24% obese. The most often histopathological type was keratinizing squamous cell carcinoma. In 68% of cases vulvar cancer was detected in II, III or IVa stage according to FIGO classifications. In 24 patients we detected p53 gene mutation. 4 patients died because of cancer recurrence, 1 because of from radiotherapy complications. CONCLUSIONS: Obesity coexists with vulvar cancer. p53 gene mutation can be etiologic factor in vulvar cancer development. Metastases in inguinal nodes are an important prognostic factor in vulvar cancer.

[The presence of Mycoplasma hominis and Ureaplasma urealyticum in the cervical canal of uterus]. / Obecnosc Mycoplasma hominis i Ureaplasma urealyticum w kanale szyjki macicy kobiet.

OBJECTIVES: Mycoplasma hominis and Ureaplasma species are common commensal inhabitants of the lower genitourinary tract in adolescents and adults who are sexually active. A lot of authors points out that these microorganisms can play an important role in pathology of genital tract like pelvic inflammatory disease, sterility or non-gonococcal urethritis. MATERIALS AND METHODS: In the study samples from cervical canal of the uterus were obtained from 222 women. The first group consist of 132 women who were examined in II Gynecological Clinic in Wroclaw for different, probably infectious, gynecological pathologies (adnexitis, sterility, bacterial vaginosis). 90 women without infectious diseases were in a control group. All swabs taken from cervix were tested for Mycoplasma hominis and Ureaplasma urealyticum. RESULTS: The prevalence of Ureaplasma urealyticum was 31.8% in the first tested group (42 of 132 women were positive) and 8.8% in control group (8 of 90 were positive). 3% (4 of 132) of patients were positive to Mycoplasma hominis in the first group and only 1.1% (1 of 90) in a control group. CONCLUSIONS: Ureaplasma urealyticum was found most often in such genital tract pathologies like acute or recurrent adnexitis, sterility or bacterial vaginosis. No statistically significant correlation was found between the age of the patients and the incidence of mycoplasmas.