ABSTRACT
A nanocarrier was obtained by coating the natural clinoptilolite particle surface with a phosphatidylcholine layer. The shell effective size does not exceed the thickness of the phospholipid molecular layer, which was confirmed by UV spectrometry and molecular mass spectrometry. The hydrodynamic diameter of the formulated nanocarrier, which was determined by dynamic light scattering, is smaller than the clinoptilolite core size. This effect is assumed to be caused by the phospholipid shell, which reduces the aqueous medium friction. The nanosize of the formulated nanocarrier, the natural clinoptilolite core, and the phospholipid shell together allow a combination of fruitful features that can be used for the fabrication of multifunctional platforms for the delivery of biologically active substances, bioimaging, or as a basis for biosensors.
Subject(s)
Nanoparticles , Zeolites , Nanoparticles/chemistry , Phosphatidylcholines , Zeolites/chemistryABSTRACT
The rhythms of short-term arousal episodes, associated with normalization of low body temperature, were studied in hibernating Erinaceus roumanicus. The episodes of body temperature recovery during hibernation were 1.7 times more incident during the acrophase of 4.058-day rhythm of glucocorticoid hormones, detected previously, than during the batiphase of this rhythm. Ultradian rhythm of arousal episodes conformed to a 4-h biorhythm: the maximum number of body temperature resumption episodes was recorded at 00.00-01.00, 04.00-05.00, 08.00-09.00, 12.00-13.00, 16.00-17.00, and 20.00-21.00. These data indicated that in mammals the mechanisms of infradian and ultradian rhythm maintenance were stable and did not depend on body temperature or were determined by external factors with periods of 4.058 days and 4 h.
Subject(s)
Body Temperature/physiology , Circadian Rhythm/physiology , Hedgehogs/physiology , Hibernation/physiology , Infradian Rhythm/physiology , Ultradian Rhythm/physiology , Animals , Biological Clocks/physiology , SeasonsABSTRACT
1,863 patients with cancer of cervix uteri received a complex radiation treatment from the ATAT-B installation in 1974-1982. Five-year survival of patients given different focal doses of 45-73 Gy (90-178 units TDF) was studied. It was found that approximately the same survival of patients treated with different focal doses within the said dose range was matched by minimal incidence and degree of radiation injuries following exposure to doses of 45-59 Gy (105-139 units TDF). Total focal dosage and TDF values, incidence rate and degree of post-radiation complications were shown to be in a direct correlation.
Subject(s)
Adenocarcinoma/radiotherapy , Brachytherapy/instrumentation , Carcinoma, Squamous Cell/radiotherapy , Uterine Cervical Neoplasms/radiotherapy , Adenocarcinoma/complications , Adenocarcinoma/mortality , Adult , Aged , Brachytherapy/adverse effects , Carcinoma, Squamous Cell/complications , Carcinoma, Squamous Cell/mortality , Cobalt Radioisotopes/administration & dosage , Female , Humans , Middle Aged , Radiation Injuries/epidemiology , Radiotherapy Dosage , Uterine Cervical Neoplasms/complications , Uterine Cervical Neoplasms/mortalityABSTRACT
Clinical appraisal is made of an associated use of radiotherapy in two groups of cervical cancer patients, subjected to intracavitary irradiation on a high-dose-rate Agat-B apparatus, depending on different dosage at point A. In the first group of patients intracavitary irradiation was carried on with single doses of 900-1200 rad and total dosage--1700-1900 rad (2600-2800 ret). The second group of patients was irradiated with single doses of 700 rad and total dosage--3000-5000 rad (1500-1800 ret). In similar early results of the treatment (85% of patients showing the recovery in stage II and 62%--in stage III) the number of early and late postradiation complications was more high (26%) in the first group than in the second (7-9%).
