Subject(s)
Abnormalities, Multiple/genetics , Chromosomes, Human, Pair 7 , Gene Duplication , Prenatal Diagnosis , Trisomy/genetics , Abnormalities, Multiple/pathology , Female , Humans , Hypertelorism/genetics , Hypertelorism/pathology , In Situ Hybridization, Fluorescence , Micrognathism/genetics , Micrognathism/pathology , Phenotype , PregnancyABSTRACT
Adenocarcinoma of the endometrium co-existing with pregnancy is a rare event. Twelve such cases have been reported in patients with intrauterine pregnancies. Co-existence with tubal ectopic pregnancy is even more uncommon. Only one such patient with tubal ectopic pregnancy was found in the literature; the pathologic findings were not, however, illustrated. We report on a very rare event, co-existing adenocarcinoma of the endometrium and ectopic tubal pregnancy, with illustration of the pathologic finding.
Subject(s)
Adenocarcinoma/pathology , Endometrial Neoplasms/pathology , Pregnancy Complications, Neoplastic/pathology , Pregnancy, Tubal/pathology , Adenocarcinoma/surgery , Adult , Endometrial Neoplasms/surgery , Female , Humans , Hysterectomy , Pregnancy , Pregnancy Complications, Neoplastic/surgery , Pregnancy, Tubal/complications , Pregnancy, Tubal/surgeryABSTRACT
This article describes how bronchoalveolar lavage specimens can be screened rapidly and inexpensively for Pneumocystis carinii and cytomegalovirus infections with materials available in any hospital laboratory.
Subject(s)
Bronchoalveolar Lavage Fluid/microbiology , Cytomegalovirus/isolation & purification , Pneumocystis/isolation & purification , Bacteriological Techniques , Culture Media , Cytomegalovirus Infections/diagnosis , Humans , Pneumonia, Pneumocystis/diagnosis , Sensitivity and SpecificityABSTRACT
The intestinal absorption and mucosal hydrolysis of a partial and a complete alpha-amylase hydrolysate of corn starch, simulating the normal intermediary and end products of luminal starch digestion, was studied using an in vivo steady state jejunal perfusion technique in normal human subjects. Alpha-amylase was excluded from the test segment by proximal balloon occlusion. Products of hydrolysis during intestinal perfusion were identified using gel permeation chromatography. Three isocaloric, isotonic sugar saline solutions containing 140 mM glucose, 70 mM maltose and the partial amylase hydrolysate of starch (51.5 +/- 1.4% of glucose content comprising glucose polymers of more than 10 glucose units) were perfused in the first study. Net glucose absorption during perfusion of the partial hydrolysate and free glucose was similar, but significantly faster from maltose (p less than 0.05). Hydrolysis of the polymer fraction containing more than 10 glucose units was significantly slower (29.5 +/- 2.0% of infused load) than the lower molecular weight fraction (56.4 +/- 3.8%, p less than 0.001). As net glucose absorption from the partial hydrolysate was similar to that from glucose, despite the slow hydrolysis of the higher molecular weight fraction, it seemed likely that oligosaccharides in the more rapidly hydrolysed lower molecular weight fractions were exerting a kinetic advantage on glucose absorption. This was confirmed in a second study, where glucose absorption from a complete amylase hydrolysate consisting predominantly of maltose, maltotriose and alpha-limit dextrins, occurred significantly faster (81.8 +/- 4.8 mmol/h/25 cm) than from isocaloric free glucose (55.8 +/- 4.9 mmol/h/25 cm, p less than 0.001). Chromatograms of intestinal aspirates suggested that (1->4), but not 1->6) linked oligosaccharides liberated during luminal and brush-border hydrolysis of dietary starch conferred a kinetic advantage on glucose absorption.
Subject(s)
Glucose/metabolism , Intestinal Absorption , Jejunum/metabolism , Starch/metabolism , alpha-Amylases/metabolism , Adult , Chromatography, Gel , Female , Humans , Hydrolysis , Jejunum/enzymology , Male , Maltose/metabolism , PerfusionABSTRACT
A nodular appearance of the esophageal mucosa was observed in 28.3% of 300 consecutive double-contrast esophagrams. This most commonly appeared as numerous uniformly sized, usually less than 3 mm, subtle, round elevations involving the entire esophageal surface. When carefully performed, endoscopy will almost always confirm these findings. Endoscopic biopsies performed in 10 patients demonstrated the nodules to represent glycogenic acanthosis--a combination of cellular hyperplasia and increased cellular glycogen. The radiographic appearance of these nodules, while usually characteristic, may vary and they may simulate pathologic processes, particularly moniliasis. Distinction can usually be made by clinical and radiologic criteria. Although the etiology is unknown, this seems to be of no clinical significance.
Subject(s)
Esophagus/pathology , Glycogen/analysis , Adult , Aged , Biopsy , Diagnosis, Differential , Esophageal Diseases/diagnosis , Esophagoscopy , Esophagus/analysis , Esophagus/diagnostic imaging , Female , Humans , Hyperplasia/diagnosis , Hyperplasia/metabolism , Male , Middle Aged , RadiographySubject(s)
Antacids , Antifoaming Agents , Surface-Active Agents , Adult , Aged , Aluminum Hydroxide/administration & dosage , Antacids/therapeutic use , Antifoaming Agents/therapeutic use , Carbonates/administration & dosage , Drug Combinations , Evaluation Studies as Topic , Female , Gastrointestinal Diseases/drug therapy , History, 16th Century , Humans , Magnesium Hydroxide/administration & dosage , Male , Middle Aged , Simethicone/administration & dosage , Surface-Active Agents/therapeutic use , TabletsABSTRACT
Two crystal forms of disopyramide have been characterized using X-ray diffraction, differential scanning calorimetry and infrared spectroscopy. The kinetics of the solid state transformation of Form I to Form II has been analysed using the Prout-Tompkins theory. An activation energy of 144 kJ mol-1 is calculated for the system. Dissolution and plasma concentrations show no significant differences in bioavailability between the two polymorphs.
