Multimodal ocular imaging of known and novel corneal stromal disorders in dogs.

BACKGROUND: Imaging features obtained with Fourier-domain optical coherence tomography (FD-OCT) and in vivo confocal microscopy (IVCM) for corneal stromal disorders have been sparsely reported in dogs. This case report is a compilation of imaging features for three cases of different stromal disorders of the canine cornea which have not yet been reported elsewhere. CASE PRESENTATION: Lipid deposition in case 1 appeared as needle-shaped hyperreflective lines along the collagen lamellae, which correlated histologically with lipid clefts. In case 2, glycosaminoglycan accumulation by mucopolysaccharidosis type 1 caused diffuse stromal hyperreflectivity and depletion of keratocytes on IVCM and was associated with secondary corneal degeneration presumed to be calcium deposition. In case 3, posterior corneal stromal opacities in the absence of ocular inflammation were identified. Hyperreflective particles were scattered in the middle and posterior corneal stroma on FD-OCT. With IVCM, hyperreflective deposits were identified within keratocytes and the number of enlarged keratocytes containing hyperreflective deposits increased towards the posterior stroma. The bilateral, non-inflammatory nature and unique appearance with IVCM is most consistent with a posterior stromal dystrophy reminiscent of pre-Descemet corneal dystrophy described in humans. CONCLUSIONS: In vivo multimodal corneal imaging facilitated instantaneous microstructural analysis and may be valuable in the differential diagnosis of corneal stromal disorders in veterinary clinical practice. The non-specific nature of imaging findings occurs in some conditions such as mucopolysaccharidosis, thus in vivo corneal imaging should be complemented with other gold standard methods of definitive diagnosis.

Outcome of retinal reattachment surgery in dogs: a retrospective study of 145 cases.

OBJECTIVE: To summarize the clinical outcomes and complications of pars plana vitrectomy with perfluoro-n-octane (PFO)-silicone oil exchange and endolaser retinopexy for treatment of retinal detachment (RD) in dogs, at one surgical center. PROCEDURE: Records of 145 dogs (168 eyes) that underwent retinal reattachment surgery (RR) between 2005 and 2009 were reviewed. All surgeries were performed by the same surgeon (SS). Data collected from the medical records included signalment, duration of time from diagnosis of RD to surgical intervention, if prior lensectomy was performed, time from surgery to restoration of vision, and postoperative complications. The data was analyzed to test the effect of breed, prior lensectomy, and time from diagnosis to surgery on visual outcome, tendency for complications, and time of complication onset. RESULTS: One hundred thirty pure-bred dogs (36 breeds) and 15 mixed-breed dogs were represented. One hundred fifty-five of 168 eyes (92%) were visual after surgery. Six of 155 eyes (3.8%) were visual before the procedure and retained vision; one hundred forty-nine of 155 eyes (96%) were nonvisual before and regained vision afterward. Thirteen of 168 eyes (8%) that were nonvisual prior to the procedure did not regain vision. The most common complications in order of occurrence included: cataract development, silicone prolapse into the anterior chamber, corneal ulceration, retinal degeneration, glaucoma, and uveitis. CONCLUSIONS: Pars plana vitrectomy with PFO-silicone oil exchange and endolaser retinopexy for treatment of RD in dogs is highly successful and associated with overall good visual outcome.