A theoretical model of anaphase.

This paper develops a theory for anaphase in cells. After a brief description of microtubules, the mitotic spindle and the centrosome, a mathematical model for anaphase is introduced and developed in the context of the cell cytoplasm and liquid crystalline structures. Prophase, prometaphase and metaphase are then briefly described in order to focus on anaphase, which is the main study of this paper. The entities involved are modelled in terms of liquid crystal defects and microtubules are represented as defect flux lines. The mathematical techniques employed make extensive use of energy considerations based on the work that was developed by Dafermos (1970) from the classical Frank-Oseen nematic liquid crystal energy (Frank, 1958; Oseen, 1933). With regard to liquid crystal theory we introduce the concept of regions of influence for defects which it is believed have important implications beyond the subject of this paper. The results of this paper align with observed biochemical phenomena and are explored in application to HeLa cells and Caenorhabditis elegans. This unified approach offers the possibility of gaining insight into various consequences of mitotic abnormalities which may result in Down syndrome, Hodgkin lymphoma, breast, prostate and various other types of cancer.

Three-dimensional fluid-structure interaction simulation of the Wheatley aortic valve.

Valvular heart diseases (such as stenosis and regurgitation) are recognized as a rapidly growing cause of global deaths and major contributors to disability. The most effective treatment for these pathologies is the replacement of the natural valve with a prosthetic one. Our work considers an innovative design for prosthetic aortic valves that combines the reliability and durability of artificial valves with the flexibility of tissue valves. It consists of a rigid support and three polymer leaflets which can be cut from an extruded flat sheet, and is referred to hereafter as the Wheatley aortic valve (WAV). As a first step towards the understanding of the mechanical behavior of the WAV, we report here on the implementation of a numerical model built with the ICFD multi-physics solver of the LS-DYNA software. The model is calibrated and validated using data from a basic pulsatile-flow experiment in a water-filled straight tube. Sensitivity to model parameters (contact parameters, mesh size, etc.) and to design parameters (height, material constants) is studied. The numerical data allow us to describe the leaflet motion and the liquid flow in great detail, and to investigate the possible failure modes in cases of unfavorable operational conditions (in particular, if the leaflet height is inadequate). In future work the numerical model developed here will be used to assess the thrombogenic properties of the valve under physiological conditions.

Precision Global Determination of the B→X_{s}γ Decay Rate.

We perform the first global fit to inclusive B→X_{s}γ measurements using a model-independent treatment of the nonperturbative b-quark distribution function, with next-to-next-to-leading logarithmic resummation and O(α_{s}^{2}) fixed-order contributions. The normalization of the B→X_{s}γ decay rate, given by |C_{7}^{incl}V_{tb}V_{ts}^{*}|^{2}, is sensitive to physics beyond the standard model (SM). We determine |C_{7}^{incl}V_{tb}V_{ts}^{*}|=(14.77±0.51_{fit}±0.59_{theory}±0.08_{param})×10^{-3}, in good agreement with the SM prediction, and the b-quark mass m_{b}^{1S}=(4.750±0.027_{fit}±0.033_{theory}±0.003_{param}) GeV. Our results suggest that the uncertainties in the extracted B→X_{s}γ rate have been underestimated by up to a factor of 2, leaving more room for beyond-SM contributions.

Top Quark Mass Calibration for Monte Carlo Event Generators.

The most precise top quark mass measurements use kinematic reconstruction methods, determining the top mass parameter of a Monte Carlo event generator m_{t}^{MC}. Because of hadronization and parton-shower dynamics, relating m_{t}^{MC} to a field theory mass is difficult. We present a calibration procedure to determine this relation using hadron level QCD predictions for observables with kinematic mass sensitivity. Fitting e^{+}e^{-} 2-jettiness calculations at next-to-leading-logarithmic and next-to-next-to-leading-logarithmic order to pythia 8.205, m_{t}^{MC} differs from the pole mass by 900 and 600 MeV, respectively, and agrees with the MSR mass within uncertainties, m_{t}^{MC}≃m_{t,1 GeV}^{MSR}.

Heavy dark matter annihilation from effective field theory.

We formulate an effective field theory description for SU(2)_{L} triplet fermionic dark matter by combining nonrelativistic dark matter with gauge bosons in the soft-collinear effective theory. For a given dark matter mass, the annihilation cross section to line photons is obtained with 5% precision by simultaneously including Sommerfeld enhancement and the resummation of electroweak Sudakov logarithms at next-to-leading logarithmic order. Using these results, we present more accurate and precise predictions for the gamma-ray line signal from annihilation, updating both existing constraints and the reach of future experiments.

Dissecting soft radiation with factorization.

An essential part of high-energy hadronic collisions is the soft hadronic activity that underlies the primary hard interaction. It includes soft radiation from the primary hard partons, secondary multiple parton interactions (MPI), and factorization-violating effects. The invariant mass spectrum of the leading jet in Z+jet and H+jet events is directly sensitive to these effects, and we use a QCD factorization theorem to predict its dependence on the jet radius R, jet p_{T}, jet rapidity, and partonic process for both the perturbative and nonperturbative components of primary soft radiation. We prove that the nonperturbative contributions involve only odd powers of R, and the linear R term is universal for quark and gluon jets. The hadronization model in Pythia8 agrees well with these properties. The perturbative soft initial state radiation (ISR) has a contribution that depends on the jet area in the same way as the underlying event, but this degeneracy is broken by dependence on the jet p_{T}. The size of this soft ISR contribution is proportional to the color state of the initial partons, yielding the same positive contribution for gg→Hg and gq→Zq, but a negative interference contribution for qq[over ¯]→Zg. Hence, measuring these dependencies allows one to separate hadronization, soft ISR, and MPI contributions in the data.

Precision jet substructure from boosted event shapes.

Jet substructure has emerged as a critical tool for LHC searches, but studies so far have relied heavily on shower Monte Carlo simulations, which formally approximate QCD at the leading-log level. We demonstrate that systematic higher-order QCD computations of jet substructure can be carried out by boosting global event shapes by a large momentum Q and accounting for effects due to finite jet size, initial-state radiation (ISR), and the underlying event (UE) as 1/Q corrections. In particular, we compute the 2-subjettiness substructure distribution for boosted Z→qq[over ¯] events at the LHC at next-to-next-to-next-to-leading-log order. The calculation is greatly simplified by recycling known results for the thrust distribution in e(+)e(-) collisions. The 2-subjettiness distribution quickly saturates, becoming Q independent for Q > or approximately equal to 400 GeV. Crucially, the effects of jet contamination from ISR/UE can be subtracted out analytically at large Q without knowing their detailed form. Amusingly, the Q=∞ and Q=0 distributions are related by a scaling by e up to next-to-leading-log order.

Beam thrust cross section for Drell-Yan production at next-to-next-to-leading-logarithmic order.

At the LHC and Tevatron strong initial-state radiation (ISR) plays an important role. It can significantly affect the partonic luminosity available to the hard interaction or contaminate a signal with additional jets and soft radiation. An ideal process to study ISR is isolated Drell-Yan production, pp → Xℓ+ ℓ- without central jets, where the jet veto is provided by the hadronic event shape beam thrust τB. Most hadron collider event shapes are designed to study central jets. In contrast, requiring τ B << 1 provides an inclusive veto of central jets and measures the spectrum of ISR. For τ B << 1 we carry out a resummation of α s(n)ln(m)τ B corrections at next-to-next-to-leading-logarithmic order. This is the first resummation at this order for a hadron-hadron collider event shape. Measurements of τ B at the Tevatron and LHC can provide crucial tests of our understanding of ISR and of τ B's utility as a central jet veto.

N jettiness: an inclusive event shape to veto jets.

Jet vetoes are essential in many analyses at the LHC and Tevatron. Typical signals have a specific number of hard jets or leptons, while backgrounds have additional jets. Vetoing undesired jets efficiently discriminates signal and background. For a sample with ≥N jets, the veto to give N energetic jets defines an "exclusive" N-jet cross section. This strongly restricts the phase space and causes large double logarithms in perturbation theory that must be summed. Jet vetoes are typically implemented using jet algorithms, yielding complicated phase-space restrictions, and reliance on leading-log parton-shower Monte Carlo simulations. We introduce a global event shape "N jettiness" τN, which is defined for events with N signal jets. Requiring τN≪1 constrains radiation between the signal jets and provides a theoretically well-controlled jet veto. N jettiness yields a factorization formula with inclusive jet and beam functions.

Infrared renormalization-group flow for heavy-quark masses.

A short-distance heavy-quark mass depends on two parameters: the renormalization scale mu and a scale R controlling the absorption of infrared fluctuations. The radius for perturbative corrections that build up the mass beyond its pointlike definition in the pole scheme is approximately 1/R. Treating R as a variable gives a renormalization-group equation. R evolution improves the stability of conversion between short-distance mass schemes, allowing us to avoid large logs and the renormalon. R evolution can also be used to study IR renormalons without using bubble chains, yielding a convergent sum rule for the coefficient of the O(Lambda(QCD)) renormalon ambiguity of the pole mass.

Precision model independent determination of |Vub| from B --> pilnu.

A precision method for determining |V(ub)| using the full range in q(2) of B --> pilnu data is presented. At large q(2) the form factor is taken from unquenched lattice QCD, at q(2) = 0 we impose a model independent constraint obtained from B --> pipi using the soft-collinear effective theory, and the shape is constrained using QCD dispersion relations. We find |V(ub)| = (3.54 +/- 0.170 +/- 0.44) x 10(-3). With 5% experimental error and 12% theory error, this is competitive with inclusive methods. Theory error is dominated by the input points, with negligible uncertainty from the dispersion relations.

Determining gamma from B --> pi(pi) decays without the CP-asymmetry Cpi(0)pi(0).

Factorization based on the soft-collinear effective theory (SCET) can be used to reduce the number of hadronic parameters in an isospin analysis of B --> pi(pi) decays by one. This gives a theoretically precise method for determining the CP violating phase gamma by fitting to the B --> pi(pi) data without Cpi(0)pi(0). SCET predicts that gamma lies close to the isospin bounds. With the current world averages we find gamma = 75 degrees +/- 2 degrees(+9 degrees)(-13 degrees), where the uncertainties are theoretical, then experimental.

Model-independent results for SU(3) violation in light-cone distribution functions.

Using chiral symmetry we investigate the leading SU(3) violation in light-cone distribution functions phi(M)(x) of the pion, kaon, and eta. It is shown that terms nonanalytic in the quark masses do not affect the shape, and only appear in the decay constants. Predictive power is retained including the leading analytic m(q) operators. With the symmetry violating corrections we derive useful model-independent relations between phi(pi),phi(eta),phiK+(,K0), and phiK(0)(,K-). Using the soft-collinear effective theory we discuss how factorization generates the subleading chiral coefficients.