ABSTRACT
In our previous studies on in situ dog hearts it has been shown that nitroglycerine has a direct myocardial effect. It was suggested that nitroglycerine is involved, besides its negative inotropic action, in active relaxation and passive diastolic properties of the heart [2, 24]. In some aspects nitroglycerine seems to be in synergy with the effect of coronary ligation. The purpose of the present study was confirmation and evaluation of the nature of the supposed direct myocardial effect of nitroglycerine, and comparison in this action with that of acute arrest of coronary perfusion in rabbit heart.
Subject(s)
Blood Pressure , Coronary Disease/physiopathology , Myocardial Contraction , Nitroglycerin/pharmacology , Animals , Blood Pressure/drug effects , Female , Muscle Relaxation/drug effects , Myocardial Contraction/drug effects , RatsABSTRACT
The regional decrease of the speed and extent of the contraction and the relaxation of the canine myocardium induced by coronary ligation was enhanced by intravenously administered nitroglycerin (GTN), simultaneously with the decrease of the left ventricular pressure, while the increase of myocardial fiber length caused by that procedure was partly abolished. The above changes could be reproduced by GTN applied directly onto the ischaemic myocardial surface even before the decrease of the left ventricular pressure. These changes induced by GTN might play a role in the decrease or abolishment of regional asynergic wall motion.
Subject(s)
Myocardial Contraction/drug effects , Nitroglycerin/pharmacology , Administration, Oral , Administration, Topical , Animals , Blood Pressure/drug effects , Coronary Disease/drug therapy , Coronary Disease/physiopathology , Depression, Chemical , Dogs , Female , Injections, Intravenous , Male , Myocardial Infarction/drug therapy , Myocardial Infarction/physiopathology , Nitroglycerin/administration & dosage , Systole , Ventricular FunctionABSTRACT
The study revealed the usefulness of the apexcardiogram in the assessment of the contractile state of left ventricle in cases of ventricular extrasystolia. The pre-ejection period/left ventricular ejection time (PEP/LVET) ratio and isovolumic contraction period (IVCP) are good parameters for demonstrating the postextrasystolic potentiation, the lack of which occurs in severe heart failure. PEP/LVET and IVCP are R-R-interval dependent in parasystolia. In the establishment of the postextrasystolic potentiation, the authors contribute an important role to the ventricular filling during the compensatory pause.
Subject(s)
Cardiac Complexes, Premature/physiopathology , Cardiomyopathies/physiopathology , Coronary Disease/physiopathology , Kinetocardiography , Adolescent , Adult , Aged , Cardiac Complexes, Premature/etiology , Cardiomegaly/complications , Cardiomyopathies/complications , Coronary Disease/complications , Heart Failure/complications , Humans , Middle Aged , Myocardial Infarction/complicationsSubject(s)
Hypertension/drug therapy , Methyldopa/therapeutic use , Adult , Aged , Blood Pressure/drug effects , Female , Heart Sounds , Humans , Kinetocardiography , Male , Methyldopa/pharmacology , Middle Aged , PhonocardiographySubject(s)
Abortion, Induced , Anesthesia, Local , Outpatient Clinics, Hospital/statistics & numerical data , Abortion, Therapeutic/adverse effects , Adolescent , Adult , Age Factors , Cervix Uteri/injuries , Child , Curettage , Dilatation , Ethnicity , Family Characteristics , Female , Follow-Up Studies , Gestational Age , Humans , Hysterectomy , Methods , Parity , Pregnancy , Uterine Hemorrhage/etiology , Uterine Rupture/etiologyABSTRACT
By the use of the thrombocyte consumption test (T.C.T.) autoantibodies reacting with heart muscle tissue have been demonstrated in 63.3% of the cases of coronary heart disease accompanied by different grades of insufficiency of the blood supply to the heart muscle. These autoantibodies could be detected two to three weeks after the onset in most patients experiencing a coronary attack for the first time, and persisted for about three to eight weeks following single attacks, whereas following recurrence in patients affected for several months or years the autoantibodies appeared in the serum most frequently within one week, and when the painful attacks were repeated, the T.C.T. remained positive for months, with only short interruptions. In cases of acute myocardial infarction the finding of a positive T.C.T. and its duration did not depend on the severity of the clinical symptoms nor on the measure of the laboratory changes but positive results were obtained more frequently in patients with acute coronary insufficiency (intermediate coronary syndrome) or angina pectoris with intense pain and frequent attacks than in patients in whom the attacks were infrequent producing slight symptoms. There was no evidence that these autoantibodies had any damaging effect.