Metabolically Unhealthy Normal Weight: Prevalence and Associated Factors in an Adult Population from Northwest Colombia.

Background and Aim: Individuals with a normal weight may have metabolic alterations at risk for chronic non-communicable diseases. The prevalence of this condition and associated factors have not been reported in Latin American populations. We aimed to estimate the presence and associated factors of Metabolically Unhealthy Normal Weight (MUNW) in adults from a public program for the control and prevention of chronic diseases in Medellín, Colombia. Methods: Cross-sectional study. Overweight and normal weight were characterized according to the absence or presence of one or more components of the metabolic syndrome, obtaining four phenotypes: Metabolically Healthy Normal Weight (MHNW), MUNW (phenotype of interest), Metabolically Healthy Overweight (MHO), and Metabolically Unhealthy Overweight (MUO). The association of these phenotypes with sociodemographic variables of lifestyles and increased waist circumference was conducted by using logistic regression. Results: In 37,558 individuals (72.7% women), the prevalence of MUNW was 23.3%. Among the additional phenotypes, MUO was found to be more prevalent (71.6%), while MHNW and MHO were very slightly common, 2% and 3.1%, respectively. In a multiple model, the factors associated with MUNW were age over 60 years (trend [OR 1.56 95% CI 0.97-2.52] p-value = 0.066), living in a rural area ([OR 1.58 95% CI 1.09-2.29] p-value = 0.015), and increased waist circumference ([OR 1.68 95% CI 1.45-1.95] p-value < 0.001). Male gender was inversely associated with all phenotypes (P < 0.05). Conclusion: Almost a quarter of the analyzed population presented MUNW. People living in a rural area and over 60 years old were more likely to present MUNW. Men were less likely to present the weight phenotypes studied, although they could have been underrepresented.

Dual burden of individual malnutrition in children 1-4 years: Findings from the Colombian nutritional health survey ENSIN 2015.

BACKGROUND: To date there are no studies with estimation of multiple types of double burden of individual malnutrition (DBIM) and evaluation of associated determinants. OBJECTIVE: To estimate the prevalence and social determinants associated with the double burden of individual malnutrition in children aged 1-4 years. METHODS: A cross-sectional study was conducted using data from Colombian nutritional heath survey ENSIN 2015. Global DBIM was analysed on the basis of excess weight and the presence of one or more micronutrient deficiencies (vitamin A, D, zinc, or iron) and/or stunting. Specific DBIM pairs were also analysed. Logistic regression was used to evaluate variables associated with DBIM. RESULTS: The sample consisted of 6807 children. The overall DBIM prevalence was 4%. The prevalence of DBIM in children affected by overweight or obesity was 75%. Male sex was associated with global DBIM (OR 2.19 (1.52-3.16) p = 0.000), indigenous children presented 6 times the DBIM due to stunting (OR 6.17 (1.67-22.7) p = 0.007). Children from the Atlantic (OR 3.95 (1.23-12.61) p = 0.021), central (OR 8.80 (2.38-32.49) p = 0.001) and Pacific (OR 4.19 (1.21-14.49) p = 0.024) regions, had a higher chance of DBIM due to iron deficiency. Children from east region (OR 3.03 (1.12-8.16) p = 0.029) and Bogotá city (OR 4.15 (1.65-12.32) p = 0.004) were associated with DBIM due to vitamin D deficiency. CONCLUSIONS: Children with overweight or obesity had a high likelihood of presenting micronutrients deficiencies or stunting. Ethnicity, male sex and country region of residence were variables associated with overall DBIM or specific DBIM.

Association of self-reported familial history of cardiometabolic disease with metabolic syndrome in apparently healthy urban Colombian men.

OBJECTIVES: Evidence about the relationship between familial history (FH) of cardiometabolic disease (CMD) and metabolic syndrome (MetS) in Latin American populations is scarce. The aim of this study was to evaluate the relationship of FH of CMD and of dyslipidemia and obesity with MetS in healthy men. METHODS: One-hundred-twenty one individuals were recruited. Waist circumference and blood pressure were measured by a trained researcher using standard techniques. Glycemia and lipid profile were determined by colorimetric assays. A survey to record personal data and family antecedents in siblings, aunts/uncles, parents, and grandparents was conducted by trained interviewers. RESULTS: Individuals having three or more familial antecedents were associated with high triglycerides level even after adjusting by age, sedentarism, fat and carbohydrates intake, and alcohol consumption. After adjusting for the same variables, FH of dyslipidemia and hypertension was also associated with high triglycerides levels and elevated waist circumference, respectively. The FH of stroke was associated with high blood pressure after adjusting for the rest of familial antecedents, and with MetS in all adjustment models. DISCUSSION: the findings of association of this study together with the previous reports are evidence of the importance of hereditary component as independent predictor of cardiovascular risk factors and its clustering, as well as of possible specific association patterns between FH of CMD and MetS depending on evaluated population in terms of ethnic groups and geographic region. Further studies are required in other populations, as well as exploration of genetic markers of CMD regarding to MetS.

Dietary zinc intake is inversely associated to metabolic syndrome in male but not in female urban adolescents.

OBJECTIVE: To evaluate the relationship of copper and zinc dietary intakes with metabolic syndrome (MetS) in adolescents. METHODS: The sample consisted of 1,311 adolescents aged 11-16 years, and MetS definition by de Ferranti et al. was used. Nutritional intakes, anthropometrical and biochemical markers were measured. RESULTS: In males, highest quartile of zinc intake was inversely associated with MetS without and with adjustment by covariables. Without adjustment, highest quartile of copper intake was inversely associated (marginal significance) with MetS, but with adjustment, the relationship was not maintained. Likewise in male gender, elevated waist circumference was the only MetS component inversely associated with highest quartiles of zinc (without and with adjustment) and copper (significant in crude analysis and marginal significant in adjustment by covariables) intakes. In the girls, only waist circumference was significant and inversely associated with highest quartiles of zinc and copper intakes but the association did not remain significant after adjustments. DISCUSSION: In the adolescents of this study, zinc intake could be more associated to a clustering of anthropometric, vascular, and metabolic alterations than to these alterations separately, and also it is inversely related to this clustering (MetS). However, studies in other populations are necessary to confirm and explain the finding of exclusive association zinc intake-MetS in male gender adolescents. Further research is required to explore biomarkers of physiological processes (antioxidant function, blood flow regulation, and epigenetic modulation dependent of zinc) in relation to zinc intake and MetS in pediatric and adult populations.

Nutrients intake as determinants of blood lead and cadmium levels in Colombian pregnant women.

OBJECTIVE: To evaluate the relationship between nutrients intake in the first trimester of pregnancy and blood levels of lead and cadmium during the first and third trimesters of gestation. METHODS: A total of 381 pregnant women were enrolled. Blood lead and cadmium were measured using electrothermal atomic absorption spectrometry, and dietary intake was assessed using 24-h recall questionnaire. RESULTS: Lead levels in the first trimester were negatively correlated with cadmium levels in the two trimesters, and levels of both metals correlated positively in the third trimester. Zinc and calcium intakes were negatively associated with blood lead during third trimester. Thiamine and folic acid intakes were negatively and positively associated (respectively) with blood lead at third trimester with marginal significance. Fat, niacin, and vitamin B12 intakes were significantly and positively associated with blood cadmium at first trimester. Folic acid and zinc intakes showed positive and marginally significant associations with blood cadmium without adjustments. At third trimester, blood cadmium was negatively associated to ascorbic acid intake, and positively associated with iron intake with a marginal significance. CONCLUSIONS: Possible acute and late effects of nutrients intake in blood lead and cadmium levels could be related with associations exclusively observed in the first and third trimester. This study represents the first exploration of relationships among a wide range of nutrients intake in the first trimester of pregnancy with blood lead and cadmium in first and third trimester of gestation. Further studies are required to confirm the findings mentioned herein.