Wavelet-based characterization of gait signal for neurological abnormalities.

Studies conducted by the World Health Organization (WHO) indicate that over one billion suffer from neurological disorders worldwide, and lack of efficient diagnosis procedures affects their therapeutic interventions. Characterizing certain pathologies of motor control for facilitating their diagnosis can be useful in quantitatively monitoring disease progression and efficient treatment planning. As a suitable directive, we introduce a wavelet-based scheme for effective characterization of gait associated with certain neurological disorders. In addition, since the data were recorded from a dynamic process, this work also investigates the need for gait signal re-sampling prior to identification of signal markers in the presence of pathologies. To benefit automated discrimination of gait data, certain characteristic features are extracted from the wavelet-transformed signals. The performance of the proposed approach was evaluated using a database consisting of 15 Parkinson's disease (PD), 20 Huntington's disease (HD), 13 Amyotrophic lateral sclerosis (ALS) and 16 healthy control subjects, and an average classification accuracy of 85% is achieved using an unbiased cross-validation strategy. The obtained results demonstrate the potential of the proposed methodology for computer-aided diagnosis and automatic characterization of certain neurological disorders.

Ambiguity domain-based identification of altered gait pattern in ALS disorder.

The onset of a neurological disorder, such as amyotrophic lateral sclerosis (ALS), is so subtle that the symptoms are often overlooked, thereby ruling out the option of early detection of the abnormality. In the case of ALS, over 75% of the affected individuals often experience awkwardness when using their limbs, which alters their gait, i.e. stride and swing intervals. The aim of this work is to suitably represent the non-stationary characteristics of gait (fluctuations in stride and swing intervals) in order to facilitate discrimination between normal and ALS subjects. We define a simple-yet-representative feature vector space by exploiting the ambiguity domain (AD) to achieve efficient classification between healthy and pathological gait stride interval. The stride-to-stride fluctuations and the swing intervals of 16 healthy control and 13 ALS-affected subjects were analyzed. Three features that are representative of the gait signal characteristics were extracted from the AD-space and are fed to linear discriminant analysis and neural network classifiers, respectively. Overall, maximum accuracies of 89.2% (LDA) and 100% (NN) were obtained in classifying the ALS gait.

Application of empirical mode decomposition and Teager energy operator to EEG signals for mental task classification.

This paper presents a novel method for mental task classification from EEG signals using Empirical Mode Decomposition and Teager energy operator techniques on EEG data. The efficacy of these techniques for non-stationary and non-linear data has already been demonstrated, which therefore lend themselves well to EEG signals, which are also non-stationary and non-linear in nature. The method described in this paper decomposed the EEG signals (6 EEG signals per task per subject, for a total of 5 tasks over multiple trials) into their constituent oscillatory modes, called intrinsic mode functions, and separated out the trend from the signal. Teager energy operator was used to calculate the average energy of both the detrended signal and the trend. The average energy was used to construct separate feature vectors with a small number of parameters for the detrended signal and the trend. Based on these parameters, one-versus-one classification of mental tasks was performed using Linear Discriminant Analysis. Using both feature vectors, an average correct classification rate of more than 85% was achieved, demonstrating the effectiveness of the method used. Furthermore, this method used all the intrinsic mode functions, as opposed to similar studies, demonstrating that the trend of the EEG signal also contains important discriminatory information.

Wavelet-based markers of ventricular fibrillation in optimizing human cardiac resuscitation.

During cardiac resuscitation from ventricular fibrillation (VF) it would be helpful if we could monitor and predict the optimal state of the heart to be shocked into a perfusing rhythm. Real-time feedback of this state to the emergency medical staff (EMS) could improve the survival rate after resuscitation. In this paper, using real world out-of-the-hospital human VF data obtained during resuscitation by EMS personnel, we present the results of applying wavelet markers in predicting the shock outcomes. We also performed comparative analysis of 5 existing techniques (spectral and correlation based approaches) against the proposed wavelet markers. A database of 29 human VF tracings was extracted from the defibrillator recordings collected by the EMS personnel and was used to validate the waveform markers. The results obtained by the comparison of the wavelet based features with other spectral, and correlation-based features indicates that the proposed wavelet features perform well with an overall accuracy of 79.3% in predicting the shock outcomes and hence demonstrate potential to provide near real-time feedback to EMS personnel in optimizing resuscitation outcomes.