ABSTRACT
This article describes the gross, histopathological, and immunohistochemical findings of a mixed thymoma in a 2-year-old, mixed-breed, female goat. A large space-occupying neoplastic growth was observed within the cranial thoracic cavity, which by histology was well-encapsulated and formed by the proliferation of spindle-shaped epithelial cells arranged in solid sheets or rosette-like formations with varying accumulations of lymphocytes. Immunohistochemistry demonstrated that the neoplastic epithelial cells expressed cytokeratin, with negative immunoreactivity to vimentin, thyroglobulin, Chromogranin A, neuron-specific enolase, and glial fibrillary acidic protein. The lymphocytic population expressed CD3 and CD2. These findings favor a diagnosis of mixed thymoma.
ABSTRACT
This article describes the gross, histopathological, and immunohistochemical findings of a mixed thymoma in a 2-year-old, mixed-breed, female goat. A large space-occupying neoplastic growth was observed within the cranial thoracic cavity, which by histology was well-encapsulated and formed by the proliferation of spindle-shaped epithelial cells arranged in solid sheets or rosette-like formations with varying accumulations of lymphocytes. Immunohistochemistry demonstrated that the neoplastic epithelial cells expressed cytokeratin, with negative immunoreactivity to vimentin, thyroglobulin, Chromogranin A, neuron-specific enolase, and glial fibrillary acidic protein. The lymphocytic population expressed CD3 and CD2. These findings favor a diagnosis of mixed thymoma.(AU)
Subject(s)
Animals , Female , Thymoma/diagnosis , Thymus Neoplasms/veterinary , Goats/physiology , Immunohistochemistry , LymphocytesABSTRACT
This report describes the pathologic and immunohistochemical findings associated with naturally occurring systemic canine distemper virus (CDV) infection in a dog. Clinically, there was lymphopenia and hyperkeratosis of footpads, while pneumonia was identified by radiology. Gross lesions consisted of bilateral ocular discharge and discrete digital hyperkeratosis. By histopathology, there was severe interstitial pneumonia and necrosis of splenic germinal centers. Additionally, eosinophilic intranuclear inclusion bodies were observed within cerebellar astrocytes without marked manifestation of CDV-induced encephalitis. Further, intracytoplasmic bodies were identified within the epithelial cells of the renal pelvis, lung, and urinary bladder. Immunohistochemistry identified the presence of CDV antigens in these tissues and further confirmed the systemic infection to the epidermis of footpads, heart, liver, intestine, spleen, and lymph node.
ABSTRACT
This report describes the pathologic and immunohistochemical findings associated with naturally occurring systemic canine distemper virus (CDV) infection in a dog. Clinically, there was lymphopenia and hyperkeratosis of footpads, while pneumonia was identified by radiology. Gross lesions consisted of bilateral ocular discharge and discrete digital hyperkeratosis. By histopathology, there was severe interstitial pneumonia and necrosis of splenic germinal centers. Additionally, eosinophilic intranuclear inclusion bodies were observed within cerebellar astrocytes without marked manifestation of CDV-induced encephalitis. Further, intracytoplasmic bodies were identified within the epithelial cells of the renal pelvis, lung, and urinary bladder. Immunohistochemistry identified the presence of CDV antigens in these tissues and further confirmed the systemic infection to the epidermis of footpads, heart, liver, intestine, spleen, and lymph node.